MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

epinastine

(WHWZLSFABNNENI-UHFFFAOYSA-N)

Structure

SMILES: NC1=NCC2N1c1ccccc1Cc1c2cccc1
Type(s): Approved; Investigational
ATC code(s): R06AX24; S01GX10
Molecular Formula:: C16H15N3
Molecular Weight:: 249.310
Log P:: 2.6677
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 1
TPSA:: 41.62
CAS Number(s):: 80012-43-7; 134507-57-6

Synonym(s)

epinastine

3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine

Flurinol

WAL 80

WAL 801

WAL 801 CL

WAL 801CL

WAL-80 Cl

epinastine hydrochloride

External Link(s)

MeSH	C053090
PubChem Compound	3241
BindingDB	50131441
ChEBI	51032
CHEMBL	CHEMBL1106
DrugBank	DB00751
DrugCentral	1027
IUPHAR/BPS Guide to PHARMACOLOGY	7176
KEGG	dr:D01713 dr:D07900
Therapeutic Target Database	D0DV3O

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 1		US FAERS
2	Abdominal symptom			OFFSIDES
3	Abdominal tenderness			OFFSIDES
4	Acid fast bacilli infection			OFFSIDES
5	Acidosis			OFFSIDES
6	Adenocarcinoma			OFFSIDES
7	Alanine Aminotransferase Increased			OFFSIDES
8	Alcoholic Intoxication			OFFSIDES
9	Allergic cystitis			OFFSIDES
10	Altered state of consciousness			OFFSIDES
11	Alveolitis			OFFSIDES
12	Anorexia			OFFSIDES
13	Apathy			OFFSIDES
14	Asthma			OFFSIDES
15	Aura			OFFSIDES
16	Automatism			OFFSIDES
17	Biloma			OFFSIDES
18	Blood Glucose			OFFSIDES
19	Blood alkaline phosphatase increased			OFFSIDES
20	Blood amylase increased			OFFSIDES
21	Blood bilirubin unconjugated increased			OFFSIDES
22	Blood creatine phosphokinase increased			OFFSIDES
23	Blood creatinine decreased			OFFSIDES
24	Blood creatinine increased			OFFSIDES
25	Blood lactate dehydrogenase decreased			OFFSIDES
26	Blood lactate dehydrogenase increased			OFFSIDES
27	Blood pH decreased			OFFSIDES
28	Blood pressure fluctuation			OFFSIDES
29	Blood thyroid stimulating hormone			OFFSIDES
30	Blood urea increased			OFFSIDES
31	Breast cancer recurrent			OFFSIDES
32	Bronchial wall thickening			OFFSIDES
33	Burning sensation in eye			SIDER
34	Cancer Pain			OFFSIDES
35	Carcinoembryonic antigen increased			OFFSIDES
36	Cardiac function test abnormal			OFFSIDES
37	Central nervous system lesion			OFFSIDES
38	Cerebellar Ataxia			OFFSIDES
39	Cheilitis			OFFSIDES
40	Chronic ulcerative colitis			OFFSIDES
41	Cold symptoms			SIDER
42	Conjunctival deposit			OFFSIDES
43	Conversion disorder			OFFSIDES
44	Depressed Level of Consciousness			OFFSIDES
45	Device related infection			OFFSIDES
46	Diarrhea			OFFSIDES
47	Drug abuser			OFFSIDES
48	Drug exposure before pregnancy			OFFSIDES
49	Dyslalia			OFFSIDES
50	Dysmenorrhea		15119752	CTD
51	Echocardiogram abnormal			OFFSIDES
52	Eczema			OFFSIDES
53	Educational problem			OFFSIDES
54	Elevated mood			OFFSIDES
55	Encephalitis			OFFSIDES
56	Enterocolitis bacterial			OFFSIDES
57	Enterocolitis			OFFSIDES
58	Eosinophilia		12689652	CTD
59	Eosinophilic Pneumonia			OFFSIDES
60	Eosinophilic myocarditis			OFFSIDES
61	Epidermolysis			OFFSIDES
62	Epilepsy			OFFSIDES
63	Erythema Multiforme			OFFSIDES
64	Erythema			OFFSIDES
65	Escherichia infection			OFFSIDES
66	Eye irritation			SIDER
67	Feeding tube complication			OFFSIDES
68	Feeling abnormal			OFFSIDES
69	Galactorrhea			OFFSIDES
70	Gamma-Glutamyltransferase Increased			OFFSIDES
71	Gastric ulcer			OFFSIDES
72	Gastrointestinal erosion			OFFSIDES
73	Gastrointestinal hypomotility			OFFSIDES
74	Glaucoma			OFFSIDES
75	Granulocyte count decreased			OFFSIDES
76	Headache			SIDER
77	Hilar lymphadenopathy			OFFSIDES
78	Hyperreflexia			OFFSIDES
79	Hyporeflexia			OFFSIDES
80	Incontinence			OFFSIDES
81	Infection			SIDER
82	Injection site ulcer			OFFSIDES
83	Intraocular lens dislocation			OFFSIDES
84	Iron binding capacity unsaturated decreased			OFFSIDES
85	Keratoconus			OFFSIDES
86	Left ventricular end-diastolic pressure decreased			OFFSIDES
87	Leukopenia neonatal			OFFSIDES
88	Limb discomfort			OFFSIDES
89	Liver Abscess			OFFSIDES
90	Lupus Nephritis			OFFSIDES
91	Lupus-like syndrome			OFFSIDES
92	Lymphangiosis carcinomatosa			OFFSIDES
93	Lymphocyte count decreased			OFFSIDES
94	Lymphocyte stimulation test positive			OFFSIDES
95	Malignant neoplasm progression			OFFSIDES
96	Mechanical ventilation			OFFSIDES
97	Metabolic acidosis			OFFSIDES
98	Multiple sclerosis relapse			OFFSIDES
99	Musculoskeletal Pain			OFFSIDES
100	Nasopharyngitis			OFFSIDES SIDER
101	Neutropenic infection			OFFSIDES
102	Neutrophil count decreased			OFFSIDES
103	Non-cardiac chest pain			OFFSIDES
104	Ocular discomfort			OFFSIDES
105	Oliguria			OFFSIDES
106	Oropharyngeal discomfort			OFFSIDES
107	Oropharyngeal pain			OFFSIDES
108	Overdose			OFFSIDES
109	Pancreatic Pseudocyst			OFFSIDES
110	Pancreatic enzymes increased			OFFSIDES
111	Pericardial effusion			OFFSIDES
112	Pharyngitis			SIDER
113	Pleurisy			OFFSIDES
114	Pneumocystis jiroveci pneumonia			OFFSIDES
115	Pneumothorax			OFFSIDES
116	Polymyositis			OFFSIDES
117	Poriomania			OFFSIDES
118	Prothrombin level decreased			OFFSIDES
119	Pruritus			SIDER
120	Psoas Abscess			OFFSIDES
121	Psychiatric symptom			OFFSIDES
122	Pustular psoriasis			OFFSIDES
123	Pyloric Stenosis			OFFSIDES
124	Renal tubular disorder			OFFSIDES
125	Retinal Vein Occlusion			OFFSIDES
126	Retroperitoneal abscess			OFFSIDES
127	Rhabdomyolysis			OFFSIDES
128	Rhinitis, Allergic, Perennial		10822083 15119752	CTD
129	Rhinitis		12167471	CTD SIDER
130	Right ventricular systolic pressure decreased			OFFSIDES
131	Septic Shock			OFFSIDES
132	Sinusitis			SIDER
133	Sjogren's Syndrome			OFFSIDES
134	Smallpox			OFFSIDES
135	Sneezing		19075512	CTD
136	Spondylitis			OFFSIDES
137	Sputum retention			OFFSIDES
138	Stevens-Johnson Syndrome			OFFSIDES
139	Subcorneal pustular dermatosis			OFFSIDES
140	Subileus			OFFSIDES
141	Tension Headache			OFFSIDES
142	Upper respiratory tract inflammation			OFFSIDES
143	Ventricular Fibrillation			OFFSIDES
144	Ventricular internal diameter abnormal			OFFSIDES

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