MetaADEDB 2.0 @ LMMD
Troponin I
(UMLS:C0077401)
Definition:
A TROPONIN complex subunit that inhibits ACTOMYOSIN ATPASE activity thereby disrupting ACTIN and MYOSIN interaction. There are three troponin I subtypes: troponin I1, I2 and I3. Troponin I3 is cardiac-specific whereas troponin I1 and I2 are skeletal subtypes. Troponin I3 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin I3 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
UMLS ID:
C0077401
MeSH ID:
D019210
Classification 1:
Name:
Macromolecular Substances
MeSH Tree Number(s):
D05.500.945.925|D05.750.078.730.825.925
Classification 2:
Name:
Amino Acids, Peptides, and Proteins
MeSH Tree Number(s):
D12.776.210.500.910.925|D12.776.220.525.825.925
Synonym(s)
1.
Troponin I
2.
Inhibitory troponin subunit
3.
TNNI
4.
TnI
5.
Troponin-I
6.
tni
7.
troponin i
8.
troponin-i
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1DasatinibFAERS: 2OFFSIDES
US FAERS
2FluorouracilOFFSIDES
3GoserelinOFFSIDES
4LeucovorinOFFSIDES
Similar ADE(s)
NameSemantic Similarity
1Troponin T53%
2C-reactive protein15.2%
3Transferrin11.7%
4Fibrin9.7%
5beta Globulin9.7%
6Prealbumin9.7%
7procalcitonin9.3%
8Chylomicrons8.2%
9Lipoprotein (a)8.2%
10Human Chorionic Gonadotropin7.3%
11Troponin6.7%
12Cryoglobulins6.1%
13Osteocalcin5.8%
14Rheumatoid Factor5.1%
15Antiphospholipid Antibodies5.1%
16Troponin I4.4%
17Carcinoembryonic Antigen4.3%
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