Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 729
Aptamer sequence: GAAGAGTAGATGAAACGTTTTTTCGCCCGATAAAAGGGACGTGCGTCAGACA
Target unique ID: Other-46
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1025 | A2 | Other | human M0-like macrophages and monocytes | 44.12 nM | 10% FBS and 100 ug/mL tRNA | 32589412 |
Structure information of aptamer
| Aptamer Sequence: | GAAGAGTAGATGAAACGTTTTTTCGCCCGATAAAAGGGACGTGCGTCAGACA |
| The optimal secondary structure in dot-bracket notation: | .....((.((((..((((.......(((.......))))))).))))..)). |
| The centroid secondary structure in dot-bracket notation: | .....((.((((..((((........((.......)).)))).))))..)). |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1025 | Description | A2 |
| Aptamer chemistry | DNA | Length | 52 nt |
| GC content | 46.2% | Molecular weight | 16,149.40 Da |
| Molarity of 1 μg/μl solution | 61.92 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted therapy |
| Sequence | GAAGAGTAGATGAAACGTTTTTTCGCCCGATAAAAGGGACGTGCGTCAGACA | ||
| Applications | Monocyte-targeted drug delivery or column selection | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Target ID | Other-46 | Name | human M0-like macrophages and monocytes |
Activity data
 |
Interaction ID | 729 |
| Target type | Other | |
| Target unique ID | Other-46 | |
| Activity | 44.12 nM | |
| Binding Conditions/Buffer | 10% FBS and 100 ug/mL tRNA |
|
| Assay | Aptamer binding to human M0-, M1-, and M2-like macrophages |
|
| PubMed ID | 32589412 | |
 |
Interaction ID | 730 |
| Target type | Other | |
| Target unique ID | Other-47 | |
| Activity | 22.81 nM | |
| Binding Conditions/Buffer | 10% FBS and 100 ug/mL tRNA |
|
| Assay | Aptamer binding to human M0-, M1-, and M2-like macrophages |
|
| PubMed ID | 32589412 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_273 | DNA | ATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAA | |
| Apta_1000 | DNA | ATAGGAGTCGACCGACCAGAACCGTTCCCATACTTCTCCAGCGATACTTAGTGCGTCTACATCTAGACTC | |
| Apta_1256 | DNA | GATCGGGTGTGGGTGGCGTAAAGGGAGCATCGGACA | |
| Apta_234 | DNA | AGCAGCACAGAGGTCAGATGAAATTTTGCACTTACTTGACGTTTCCTCGATAGCCACAAGCCTATGCGTGCTACCGTGAA | |
| Apta_1004 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCACTGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1007 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_997 | DNA | ATAGGAGTCGACCGACCAGACCCCGCCTCTCCTTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1172 | DNA | GACGCCACTGACTACCCCAGTATCTCTTCAACGCGTATTGAAGTCAGTCGGTCGTCA | |
| Apta_139 | DNA | GATAAACGCCTTGATTAAAGGCCCAGTTCTTTAGGCCTACACGTGCTGCGACATTAATT | |
| Apta_278 | DNA | AGCAGCACAGAGGTCAGATGAGGCCTGGTGATCGTGCCCAGGCCATATGAGCAAGGAACCCCTATGCGTGCTACCGTGAA | |
| Apta_1003 | DNA | ATAGGAGTCGACCGACCAGACCCCGCCTCTCCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1005 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1010 | DNA | ATAGGAGTCGACCGACCAGACCGACCCTCGTCGTACCAACTGATGACCTAGTGGCGTCTACATCTAGACTC | |
| Apta_257 | DNA | GGCAGAAGAAATATCGAAACCCAGAATGGTCGGCCAGGCG | |
| Apta_343 | DNA | AACAGAGGGACAAACGGGGGAAGATTTGACGTCGACGAC | |
| Apta_586 | DNA | GGGAGACAAGGAAAATCCTTCAATGAAGTGGGTCGACA | |
| Apta_916 | DNA | GGCGTATGCAGTTTTGTAGGGTTATCAAGGCTTGACGATT | |
| Apta_928 | DNA | GATTGAGTAGATAGTGGTTCTGTACGTAGTGAAAGAGTGG | |
| Apta_964 | DNA | CACGAGAGGGGTGAGGTGTCGTATTAGAGGGAAGCTCCAA | |
| Apta_973 | DNA | TATGTAATGTTGACGTAATTTATCTCTGTGAGAATAAGCAGGTGGTATCC |
DEV TOOL
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