AptaDB: Result

Interaction ID: 1003

Aptamer sequence: TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA

Target unique ID: Other-30

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_910	N	Other	vasopressin (D-VP)	1.2 μM	20 mM sodium 2-[bis(2-hydroxyethyl)amino]ethane sulfonate, pH 7.3, with 140 mM NaCl, 5 mM KCl, 1.5 mM MgCl2, 1 mM CaCl2, and 0.02% Triton X-100	9326601

Aptamer Sequence:	TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA
The optimal secondary structure in dot-bracket notation:	((((((((((....((((((...)))))).....((.....))..))))))))))
The centroid secondary structure in dot-bracket notation:	((((((((((..((.(((((..............))))).))...))))))))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_910	Description	N
Aptamer chemistry	DNA	Length	55 nt
GC content	58.2%	Molecular weight	17,047.91 Da
Molarity of 1 μg/μl solution	58.66 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA
Applications	Vasopressin antagonist

Type	Detail	Type	Detail
Target ID	Other-30	Name	vasopressin (D-VP)

	Interaction ID	1003
	Target type	Other
	Target unique ID	Other-30
	Activity	1.2 μM
	Binding Conditions/Buffer	20 mM sodium 2-[bis(2-hydroxyethyl)amino]ethane sulfonate, pH 7.3, with 140 mM NaCl, 5 mM KCl, 1.5 mM MgCl2, 1 mM CaCl2, and 0.02% Triton X-100
	Assay	Equilibrium dialysis studies of mirror image aptamers
	PubMed ID	9326601

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1213	DNA	GGACTTGAAGAAAAGGGCGACACGCGAAGTCGATGTCGCGTCTGCCTGAAGTCA	60.00%
Apta_1117	DNA	CGTACGGAATTCGCTAGCGGACTGGAGTCTAGACCGGGTAGCTGTGGTGGATCCGAGCTCCACGTG	59.09%
Apta_391	DNA	ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT	58.18%
Apta_259	DNA	GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT	56.36%
Apta_692	DNA	ACGTTGACGCTGGTGCCCGCTTGTGGTGCGAGTGTTGTGT	56.36%
Apta_1276	DNA	TCAATGGGATGTTAGTATGCAAAGATATTCTGTTCAGTGTGTGCCCAGGCCCCCAGGG	55.17%
Apta_726	DNA	TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC	54.93%
Apta_1217	DNA	ATACGAGCTTGTTCAATACGAAGGGATGCCGTTTGGGCCCAAGTTCGGCATAGTGTGGTGATAGTAAGAGCAATC	54.67%
Apta_58	DNA	GCACCTTGATGACATGATAGTCGTTGTGTATGCAGTTGGC	54.55%
Apta_149	DNA	CCGTAGGTTCGGGGTCGGAGTGGTCCGGAAGATGGCGTGG	54.55%
Apta_340	DNA	TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA	54.55%
Apta_507	DNA	GGCGGGGCTACGAAGTAGTGATTTTTTCCGATGGCCCGTG	54.55%
Apta_729	DNA	AACACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCCGGTG	54.55%
Apta_845	DNA	CCAAACGCGCTGGTTTGGAATGCTTAGAGTTTGATCGATGCCTAA	54.55%
Apta_846	DNA	GTGCAGACAGCTAGTAGTGGTGACTTTCTGTCCAAATCAAGATAA	54.55%
Apta_960	DNA	CCCGAGGCACGAGGGGGAACGTATCGTCATGTGCCGGCCA	54.55%
Apta_965	DNA	CACGGCATGTGTGGCCGGATGCCTATATCGGTCGACTGCA	54.55%
Apta_1013	DNA	ATCACGTATGGGGGGCCGGCATGAGGGCCGCGCGTGACA	54.55%
Apta_1026	DNA	GGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTG	54.55%
Apta_1138	DNA	GCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG	54.55%

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