Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 139
Aptamer sequence: GGAGGUGCUCCGAAAGGAACUCC
Target unique ID: P01857
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_138 Apt8-2 Protein IGHG1_HUMAN 75 nM 145mM NaCl, 5.4 mM KCl, 0.8mM MgCl, 1.8 mM CaCl, and 20 mM Tris-HCl (pH 7.6) 18441054
Structure information of aptamer
Aptamer Sequence: GGAGGUGCUCCGAAAGGAACUCC
The optimal secondary structure in dot-bracket notation: ((((....(((....))).))))
The centroid secondary structure in dot-bracket notation: ((((....(((....))).))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_138 Description Apt8-2
Aptamer chemistry RNA Length 23 nt
GC content 60.9% Molecular weight 7,664.44 Da
Molarity of 1 μg/μl solution 130.47 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence GGAGGUGCUCCGAAAGGAACUCC
Applications Recognize and bind to human IgG with high specificity and affinity
Target information
Type Detail Type Detail
Uniprot ID P01857 Protein name Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Gene name(s) IGHG1 Organism Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Status reviewed in uniprot database Length 330
Mass 36,106 Activity regulation N/A
Involvement in disease Multiple myeloma (MM) Catalytic activity N/A
PDB ID(s)
1AJ7;1AQK;1AXS;1BEY;1D5B;1D5I;1D6V;1DFB;1DN2;1E4K;1FC1;1FC2;1FCC;1GAF;1H3T;1H3U;1H3V;1H3W;1H3X;1H3Y;1HKL;1HZH;1I7Z;1L6X;1N7M;1OQO;1OQX;1PG7;1T83;1T89;1VGE;2DTS;2GJ7;2I5Y;2IWG;2J6E;2JB5;2JB6;2O5X;2O5Y;2O5Z;2OSL;2QAD;2QL1;2QQK;2QQL;2QQN;2QR0;2R56;2RCS;2VXQ;2WAH;3AGV;3AVE;3AY4;3B2U;3B2V;3BDY;3BE1;3BKY;3BN9;3BQU;3C08;3C09;3C2S;3CFJ;3CFK;3CSY;3D0L;3D0V;3D6G;3D85;3DJ9;3DNK;3DO3;3DRO;3DRQ;3DVG;3DVN;3EYF;3EYO;3EYQ;3FJT;3MCL;3O11;3RY6;3S7G;3SGJ;3SGK;3TV3;3TWC;3TYG;3U0W;3U7W;3U7Y;3V7M;3V8C;3V95;3WJJ;3WJL;3WKN;3WN5;4ACP;4B7I;4BM7;4BSV;4BSW;4BYH;4CDH;4D9Q;4D9R;4DAG;4DZ8;4EOW;4HIX;4J12;4KU1;4LLD;4LLM;4LLQ;4N0U;4NQS;4NQT;4NQU;4NWT;4NWU;4O4Y;4O51;4Q6Y;4Q74;4Q7D;4W4N;4W4O;4WI2;4WI3;4WI4;4WI5;4WI6;4WI7;4WI8;4WI9;4X4M;4X98;4X99;4XMP;4XNY;4XNZ;4XXD;4ZNE;5BW7;5C7K;5D4Q;5D6D;5DI8;5DJ0;5DJ2;5DJ6;5DJ8;5DJA;5DJC;5DJD;5DJX;5DJY;5DJZ;5DK0;5DK2;5DVK;5DVL;5DVM;5DVN;5DVO;5GSQ;5HSF;5HY9;5HYE;5HYF;5HYI;5IQ7;5IQ9;5IW3;5IW6;5JIH;5JII;5JIK;5K33;5K64;5K65;5K8D;5KWG;5M3V;5TPS;5U4Y;5U52;5U66;5V43;5V4E;6DCV;6DCW;6DE7;6F2Z;6G1E;6N35;6YT7;7KWO;7LUR;
Function Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.
Activity data

No relevant experimental diagram

 Interaction ID 139
Target type Protein
Target unique ID P01857
Activity 75 nM
Binding Conditions/Buffer

145mM NaCl, 5.4 mM KCl, 0.8mM MgCl, 1.8 mM CaCl, and 20 mM Tris-HCl (pH 7.6)
Assay

N/A
PubMed ID 18441054
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_712 RNA GGCGGUGCUCGCCGAAAGGCUCCUGGAUACGUC 60.61%
Apta_713 RNA GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC 60.61%
Apta_714 RNA GGCGGUUCCUGCCGAAAGGCUCGUGGCAACGUC 57.58%
Apta_371 RNA GGCAGACCAUACGGGAGAGAAACUUGCC 57.14%
Apta_560 RNA GGAAGAGAUGGCGACUAAAACGACUUGUCGC 54.84%
Apta_715 RNA GGCGCUGCACGCCGAAAGGCCCGUUGAAACGUC 54.55%
Apta_716 RNA GGCGCUUCAUGCCGAAAGGCCCGUUGUAACGUC 54.55%
Apta_717 RNA GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC 54.55%
Apta_60 DNA GGAATGAGTGCCCTGCAAGCGAGGGCTAGC 53.33%
Apta_634 RNA GGUCUUACGUCGUUCGCGACUAUUGGGAGACC 53.12%
Apta_1292 RNA GGCACGUGUAUUACCCUAGUGGUCGACGUGCC 53.12%
Apta_384 RNA AUGAUCAAUCGCCUCAAUUCGACAGGAGGCUCAC 52.94%
Apta_370 RNA GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG 52.63%
Apta_700 DNA GCAGGGGCGTTCGGGGGGTACCGCTGC 51.85%
Apta_711 RNA GGCGAUACCAGCCGAAAGGCCCUUGGCAGCGUC 51.52%
Apta_362 DNA GGGAACGCACCGATCGCAGGTTTCCC 50.00%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 50.00%
Apta_1058 RNA GUAAGGCAGCUUACAAACAUUAAGGCACAG 50.00%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 50.00%
Apta_1167 RNA GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC 50.00%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

HELP CENTER

>Contact us
>LMMD Group
>School of Pharmacy

DEV TOOL
Page last updated at 2022-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 43963
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.