Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1000
Aptamer sequence: GGCACGUGUAUUACCCUAGUGGUCGACGUGCC
Target unique ID: 135398634
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1292 XBA Molecule Guanine 1.3 μM 20 mM Tris-HCl (pH 7.5), 0.3 M NaCl and 5 mM MgCl2 9512549
Structure information of aptamer
Aptamer Sequence: GGCACGUGUAUUACCCUAGUGGUCGACGUGCC
The optimal secondary structure in dot-bracket notation: (((((((..(((((....)))))..)))))))
The centroid secondary structure in dot-bracket notation: (((((((..(((((....)))))..)))))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1292 Description XBA
Aptamer chemistry RNA Length 32 nt
GC content 59.4% Molecular weight 10,232.08 Da
Molarity of 1 μg/μl solution 97.73 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence GGCACGUGUAUUACCCUAGUGGUCGACGUGCC
Applications Binding to xanthine
Target information
Type Detail Type Detail
PubChem ID 135398634 Molecular name Guanine
Molecular formula C5H5N5O Molecular weight 151.13
IUPAC name 2-amino-1,7-dihydropurin-6-one InChIKey UYTPUPDQBNUYGX-UHFFFAOYSA-N
LogP -0.772 Topological polar surface area 100.45
Hydrogen bond acceptor 4 Hydrogen bond donor 3

Synonym(s):
guanine; 73-40-5; 2-Amino-6-hydroxypurine; Guanin; 2-Aminohypoxanthine; Mearlmaid; Pearl essence; Guanine enol; Stella Polaris; Dew Pearl; Natural pearl essence; Natural white 1; 6H-Purin-6-one, 2-amino-1,7-dihydro-; 2-Amino-6-purinol; C.I. Natural White 1; CI Natural white 1; Hypoxanthine, 2-amino-; 6-Hydroxy-2-aminopurine; 2-Amino-1,7-dihydro-6H-purin-6-one; 2-amino-1H-purin-6(7H)-one; 2-amino-1,9-dihydro-6H-purin-6-one; 2-amino-1,7-dihydropurin-6-one; C.I. 75170; HSDB 2127; CI 75170; Mearlmaid AA; 6H-Purin-6-one, 2-amino-1,9-dihydro-; 2-amino-9H-purin-6-ol; AI3-24393; UNII-5Z93L87A1R; 2-AMINO-3H-PURIN-6(7H)-ONE; 2-Amino-6-hydroxy-1H-purine; CHEBI:16235; 2-amino-1,9-dihydropurin-6-one; MFCD00071533; 6H-purin-6-one, 2-amino-3,7-dihydro-; CHEMBL219568; 2-amino-1h-purin-6(9h)-one; 5Z93L87A1R; 2-Amino-1,9-dihydro-purin-6-one; 2-amino-6,7-dihydro-3H-purin-6-one; GUA; GUN; 2-amino-6-hydroxypurin; EINECS 200-799-8; 7H-Purin-6-ol, 2-amino-; 9H-Purin-6-ol, 2-amino-; 9h-guanine; Guanine, BioUltra; Guanine,(S); Guanine (8CI); 2-amino-6-oxypurin; 2-amino-Hypoxanthine; Guanine, 98%; 1H-Purin-6-ol, 2,3-dihydro-2-imino-; Aciclovir EP Impurity B; 2-amino-7H-purin-6-ol; bmse000090; Epitope ID:140098; SCHEMBL5259; Oprea1_875298; GTPL4556; DTXSID9052476; SCHEMBL16389311; ZINC895129; ALBB-025935; BCP26793; HY-Y1055; Valacyclovir hydrochloride, guanine-; BBL009290; BBL009641; BDBM50200094; s4888; STK297804; STK801924; AKOS000118904; AKOS001426592; AKOS005139176; AKOS016002094; Valganciclovir hydrochloride impurity b; AC-4743; AM81389; CS-6269; DB02377; MCULE-7938010131; 2-amino-3,7-dihydro-6H-purin-6-one; 2-amino-6,9-dihydro-1H-purin-6-one; NCGC00246975-01; 66224-61-1; 66224-63-3; 66224-64-4; 71660-31-6; 71660-36-1; AS-10918; Guanine, Vetec(TM) reagent grade, 99%; NCI60_012450; AB0008420; DB-015937; FT-0611249; G0169; EN300-21473; 1569-EP2270010A1; 1569-EP2270505A1; 1569-EP2272517A1; 1569-EP2272848A1; 1569-EP2292088A1; 1569-EP2292593A2; 1569-EP2295441A2; 1569-EP2295503A1; 1569-EP2298783A1; 1569-EP2301536A1; 1569-EP2301538A1; 1569-EP2305250A1; 1569-EP2305808A1; 1569-EP2311455A1; 1569-EP2316452A1; A15593; C00242; 2-Amino-1,7-dihydro-6H-purin-6-one (Guanine); 6H-Purin-6-one, 2-amino-1,7-dihydro- (9CI); A866095; Q169313; W-104453; F8880-3425; Z256709612; 3D215030-CD54-4835-A5F4-F00F86B90978; Guanine, United States Pharmacopeia (USP) Reference Standard; Phosphonium,[3-(dimethylamino)propyl]triphenyl bromide hydrobromide; Guanine, Pharmaceutical Secondary Standard; Certified Reference Material; Acyclovir EP Impurity B; Valaciclovir EP Impurity A; Valaciclovir USP Related Compound A; 2-Amino-1,9-dihydro-6H-purin-6-one

Activity data

No relevant experimental diagram

 Interaction ID 803
Target type Molecule
Target unique ID 1188
Activity 3.3 μM
Binding Conditions/Buffer

20 mM Tris-HCl (pH 7.5), 0.3 M NaCl and 5 mM MgCl2
Assay

N/A
PubMed ID 9512549

No relevant experimental diagram

 Interaction ID 1000
Target type Molecule
Target unique ID 135398634
Activity 1.3 μM
Binding Conditions/Buffer

20 mM Tris-HCl (pH 7.5), 0.3 M NaCl and 5 mM MgCl2
Assay

N/A
PubMed ID 9512549
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1167 RNA GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC 58.33%
Apta_367 RNA CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC 57.50%
Apta_371 RNA GGCAGACCAUACGGGAGAGAAACUUGCC 56.25%
Apta_633 RNA GGCAUCGGAAAGUGGGUUGAUGUAAGUAACAGGCGAUGCC 55.00%
Apta_85 RNA UGCGACUGUUAUAACCUAACAGCGACGUAAAGAUA 54.29%
Apta_138 RNA GGAGGUGCUCCGAAAGGAACUCC 53.12%
Apta_634 RNA GGUCUUACGUCGUUCGCGACUAUUGGGAGACC 53.12%
Apta_955 RNA ACGUAUCCCUUUUCGCGUA 53.12%
Apta_956 RNA ACGUUUCCCUUUUCGCGUA 53.12%
Apta_315 RNA GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA 52.94%
Apta_313 RNA UGCCCUGCCCUCACCCGUUAGCCUGAGCGCCCCGCA 52.78%
Apta_365 RNA GGACCUAUGCAGUAGCCAGUGUGGACUGGGCUGCCCCCCC 52.50%
Apta_658 RNA CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC 52.50%
Apta_152 RNA UUACCACGCGCUCUUAACUGCUAGCGCCAUGGC 51.52%
Apta_289 RNA GGGGGCUUAUCAUUCCAUUUAGUGUUAUGAUAACC 51.43%
Apta_1 RNA ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA 51.35%
Apta_51 RNA GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC 51.28%
Apta_1121 RNA GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC 51.06%
Apta_132 RNA GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA 50.98%
Apta_133 RNA GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA 50.98%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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