Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 794
Aptamer sequence: GGGUUGUGAGCUCCCGGCUCGCAUUGUGAGGUGGAGGGGGACGUGCUGCAGGUCGACGCAUGCGCCG
Target unique ID: 644282
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_718 ApT4-A32nt-5 Molecule [125I]-Thyroxine 50 μM 10 mM Tris-HCl (pH 7.5), 500 mM NaCl, and 1 mM MgCl2 17163839
Structure information of aptamer
Aptamer Sequence: GGGUUGUGAGCUCCCGGCUCGCAUUGUGAGGUGGAGGGGGACGUGCUGCAGGUCGACGCAUGCGCCG
The optimal secondary structure in dot-bracket notation: .....((...((((((.(((((...))))).))).)))..))(((((((........))).))))..
The centroid secondary structure in dot-bracket notation: ..........((((((.(((((...))))).))).)))........(((........))).......
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_718 Description ApT4-A32nt-5
Aptamer chemistry RNA Length 67 nt
GC content 68.7% Molecular weight 21,790.91 Da
Molarity of 1 μg/μl solution 45.89 μM Number of G-quadruplexes 2
G-Score 21 Function Targeted binding
Sequence GGGUUGUGAGCUCCCGGCUCGCAUUGUGAGGUGGAGGGGGACGUGCUGCAGGUCGACGCAUGCGCCG
Applications Binding to theophylline
Target information
Type Detail Type Detail
PubChem ID 644282 Molecular name [125I]-Thyroxine
Molecular formula C15H11I4NO4 Molecular weight 774.87
IUPAC name (2S)-2-amino-3-[4-(4-hydroxy-3-(125I)iodanyl-5-iodophenoxy)-3,5-diiodophenyl]propanoic acid InChIKey XUIIKFGFIJCVMT-SUXPHOQTSA-N
LogP 4.557 Topological polar surface area 92.78
Hydrogen bond acceptor 4 Hydrogen bond donor 3

Synonym(s):
[125I]-Thyroxine; [125I]-T4; 80945-46-6; [125I]thyroxine; [125I]-Thyroxin; [125I]-Synthroid; [125I]-Thyratabs; [125I]-Thyroxinal; [125I]-Thyreoideum; [125I]-Thyrax; [125I]-Levothyroxine; [125I]-L-Thyroxin; [125I]-L-Thyroxine; [125I]-Thyroxine iodine; [125I]-Tetraiodothyronine; [125I]-Thryroxine, l-; [125I]-Thyroxine (l); [125I]-(-)-Thyroxine; [125I]-T4 (Hormone); [125I]-Thyroxine (VAN); GTPL4627; [125I]-Levothyroxinum (acid); [125I]-Laevothyroxinum (acid); DTXSID30349358; [125I]-THX; [125I]-CCRIS 6739; [125I]-HSDB 3108; [125I]-L-T4; [125I]-3,5,3',5'-Tetraiodothyronine; [125I]-NSC 36397; [125I]-L-3,5,3',5'-Tetraiodothyronine; [125I]-3,3',5,5'-Tetraiodo-L-thyronine; [125I]-3,5,3',5'-Tetraiodo-L-thyronine; [125I]-3,3',5,5''-Tetraiodo-L-thyronine; [125I]-O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; [125I]-L-tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-; L-tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-[125I]-3,5-diiodo-; 3-(4-(4-Hydroxy-[125I]-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine; 3-[4-(4-Hydroxy-[125I]-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine; beta-(([125I]-3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine; (2S)-2-amino-3-{4-[4-hydroxy-3-(125I)iodo-5-iodophenoxy]-3,5-diiodophenyl}propanoic acid; 2-amino-3-[4-(4-hydroxy-[125I]-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid

Activity data

No relevant experimental diagram

 Interaction ID 794
Target type Molecule
Target unique ID 644282
Activity 50 μM
Binding Conditions/Buffer

10 mM Tris-HCl (pH 7.5), 500 mM NaCl, and 1 mM MgCl2
Assay

N/A
PubMed ID 17163839
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_594 RNA GGGCUAUUGCUGGAGGGGCGCCACAUGAAAGUGGUGGUUGGGUGCGGUCGGCGAUAGCUC 56.72%
Apta_130 RNA GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA 55.07%
Apta_256 RNA GGGCGCUAAGUCCUCGCUCAUGCGCGUCCCAUGGGGUAUAGAGGGGUCGAAGUGGACGCGCGACUCGGAUCCU 54.79%
Apta_305 RNA GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC 54.29%
Apta_886 RNA GGGAGACGAUAUUCGUCCAUUCGGGUGGCCCGUGUCUGAGCGGGGACGGCCACUUGAGCGCCGCUGUCCGACUGAAUUCUCGACC 54.12%
Apta_134 RNA GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA 53.73%
Apta_315 RNA GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA 53.73%
Apta_575 RNA AGAGCUUGACGGUCCCGAGAGUCGAGCCCAAGCUGACACUGGACCUUUGCGGACCACGUGUUGAUCGUCG 52.86%
Apta_1053 RNA GCCGCAAGUACGAGGGCGGCGCGCUCGACGCGGUUAGAUGAGUGUCGCCGUUUCCGAAGAUUGGCUACGCGGGG 52.70%
Apta_623 RNA GGGAAUGGAUCCACAUCUACGAAUUCACCGCGGGGUUGCGGACCGGGAGCUCCAGCUUCACUGCAGACUUGACGAAGCUU 52.50%
Apta_131 RNA GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA 52.24%
Apta_135 RNA GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA 52.24%
Apta_561 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUGUGGAAACAGACGUGGCACAUGACUACGUCGAAACGGUAGCGAGAGCUC 52.22%
Apta_380 RNA GGGAUGCUUCGGCAUCCCCGAAGCCGCUAUGGACCAGUGGCGCGGCUUCGGCCCGACGGAGUGGUACCGCUUCGGCGGUACGUAAGCUUGGG 52.17%
Apta_496 RNA GGGCUAGCUGAUCGUACCCAGUAGCGUGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC 52.17%
Apta_171 RNA GGGAGCUCAGAAUAAACGCUCAACCAGUCUUGUGGCUUUGAAAGAGAGGAGUGUUCGACAUGAGGCCCGGAUCCGGC 51.95%
Apta_1017 DNA TAGGGAATTCGTCGACGGATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGGTCGACGCATGCGCCG 51.90%
Apta_429 RNA GCAUGCAGUGUCUAUUCUCGAGUAGCGAUCGUUGAAGGGGUAUAAGGUUGGCAGAUCGCUAGCAUGCAACUGACUCGGAUAAGCA 51.76%
Apta_453 RNA GGGCUAGCUGAUCGUACCAGUAGCGUGGCCUGGGGGGCCUAGUCGUGCGAUACUAACAGCUAACACCC 51.47%
Apta_414 RNA GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA 51.25%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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