Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_927 | TAFapt4 | Other | leukemic AML1-MTG8 fusion protein | 7.76 nM | 20 mM sodium phosphate (pH 6.5), 2 mM magnesium acetate, 200 mM potassium acetate, 5% glycerol, 0.05% Triton X-100, 5 mM b-mercaptoethanol | 32870501 |
Structure information of aptamer
| Aptamer Sequence: | UUACAAUGAGGUGGGACGCGGGUUGUGGUG |
| The optimal secondary structure in dot-bracket notation: | (((((((...(((...)))..))))))).. |
| The centroid secondary structure in dot-bracket notation: | .((((((...(((...)))..))))))... |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_927 | Description | TAFapt4 |
| Aptamer chemistry | RNA | Length | 30 nt |
| GC content | 56.7% | Molecular weight | 9,781.82 Da |
| Molarity of 1 μg/μl solution | 102.23 μM | Number of G-quadruplexes | 2 |
| G-Score | 19 | Function | Targeted therapy |
| Sequence | UUACAAUGAGGUGGGACGCGGGUUGUGGUG | ||
| Applications | The aptamer could bind to the AML1-MTG8 fusion protein and dissociate the AML1-MTG8/DNA complex, suggesting that it can inhibit the dominant negative effects of AML1-MTG8 against normal AML1 function and serve as a potential therapeutic agent for leukemia | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Target ID | Other-34 | Name | leukemic AML1-MTG8 fusion protein |
Activity data
|
No relevant experimental diagram |
Interaction ID | 1017 |
| Target type | Other | |
| Target unique ID | Other-34 | |
| Activity | 7.76 nM | |
| Binding Conditions/Buffer | 20 mM sodium phosphate (pH 6.5), 2 mM magnesium acetate, 200 mM potassium acetate, 5% glycerol, 0.05% Triton X-100, 5 mM b-mercaptoethanol |
|
| Assay | N/A |
|
| PubMed ID | 32870501 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_319 | RNA | ACCCUGAUGGUAGACGCCGGGGUG | |
| Apta_1166 | RNA | GAUGUAACUGAAUGAAAUGGUGAAGGACGGGUCCAGUAGGCUGC | |
| Apta_379 | RNA | UACGACACGAUUGGGACGUGUCUAUGGGAC | |
| Apta_1194 | DNA | GGGAGAGGTGGGAGCGGGGCCAGGG | |
| Apta_231 | RNA | GGGAGGACGAUGCGGGUGUGGGGCG | |
| Apta_245 | DNA | ACAGGGGTGTGGGGACAGGGGTGTGGGG | |
| Apta_926 | RNA | UCGGCAGCGGUUAGAGAGGUGGUGUGCGGG | |
| Apta_242 | RNA | GCUUCCAGGAAGAGAAGUGUCAUGUGAUCAGUCCUGGUGGGUGG | |
| Apta_96 | RNA | UCGCUAAUUAUAGGCGGAGUGCGACGUUAUAAAUA | |
| Apta_230 | RNA | GGGAGGACGAUGCGGGCGUGAAUGGUGUUGUGAGG | |
| Apta_11 | DNA | AGAGGGGGGGGTCGGGGTGGGTCGC | |
| Apta_13 | DNA | AGGGGGGGGGGAGGGGTCGGGGTGG | |
| Apta_241 | RNA | GCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGG | |
| Apta_244 | RNA | GCUUCCGGAGAGAAGGGUCAAAGUUGUGCGGGAGUGUGUUGUGG | |
| Apta_320 | DNA | GCACTCTGTGGGGGTGGACGGGCCGGGT | |
| Apta_402 | RNA | GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC | |
| Apta_925 | RNA | GCUCGGCCAGGUCGCGGGUGGAUGUGAGGG | |
| Apta_243 | RNA | GCUUGAAGCUAGCAGUAAGACUAGCGCUACGGAUGGGUGUGCG | |
| Apta_649 | DNA | GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGCGTG | |
| Apta_89 | RNA | AAUAACCUUAAUGCGACGUUGGUUCGUCAACAUGG |
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