AptaDB: Result

Interaction ID: 315

Aptamer sequence: CAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCG

Target unique ID: P14151

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_306	LD201	Protein	LYAM1_HUMAN	1.8 nM	20 mM Hepes (pH 7.5), 125 mM NaCl, 1 mM CaCl2, 1 mM MgCl2, 5 mM KCl plus 0.01% (wt/vol) human serum albumin	8981912

Aptamer Sequence:	CAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCG
The optimal secondary structure in dot-bracket notation:	.......(((.......)))((((.......))))....
The centroid secondary structure in dot-bracket notation:	........((.......))....................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_306	Description	LD201
Aptamer chemistry	DNA	Length	39 nt
GC content	46.2%	Molecular weight	12,288.72 Da
Molarity of 1 μg/μl solution	81.38 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	CAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCG
Applications	Inhibit L-selectin binding to immobilized SLex in static assays and inhibit L-selectin-mediated rolling of human lymphocytes and neutrophils on cytokine-activated endothelial cells in flow-based assays

Type	Detail	Type	Detail
Uniprot ID	P14151	Protein name	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Gene name(s)	SELL LNHR LYAM1	Organism	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Status	reviewed in uniprot database	Length	372
Mass	42,187	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	2LGF;3CFW;5VC1;
Function	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells.

No relevant experimental diagram	Interaction ID	315
	Target type	Protein
	Target unique ID	P14151
	Activity	1.8 nM
	Binding Conditions/Buffer	20 mM Hepes (pH 7.5), 125 mM NaCl, 1 mM CaCl2, 1 mM MgCl2, 5 mM KCl plus 0.01% (wt/vol) human serum albumin
	Assay	N/A
	PubMed ID	8981912

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_309	DNA	TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC	79.59%
Apta_309	DNA	TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC	79.59%
Apta_1158	DNA	CCAGTACAAGGTGCTAAACGTAAT	61.54%
Apta_32	DNA	CGGTAAACTGCGTCCGAAGGGGCTGCAGTGACCCGAATGGGTCCG	57.78%
Apta_1044	DNA	TTTAACGTAACCTGCAAGGCGGGGAGGTGCGAGCCCCGTGTGTGGCTTGC	54.00%
Apta_679	DNA	CAGGTGGCAGATCGGGTGTGGGTGGCCTGG	53.85%
Apta_640	DNA	CAATGGACCTATTCGAGTACTGAATAGAACAGTCGGCGCTCTGGG	53.33%
Apta_644	DNA	TCAATCTAACCATGCATGCAGTTTAGGCAGGATTCGTTATCGCAA	53.33%
Apta_834	DNA	CGCAATACCAAAGTGGCGAGAGCGCTGTCTTGAGTGAGTGGTTGG	53.33%
Apta_592	DNA	CTCTCGGGACGACCACTACGCATAGTTTCTATCGCCAGGAAGGGTCGTCCC	52.94%
Apta_385	DNA	ACAGATACGGAACTACAGAGGTCAATTACGGTGGCCACGC	52.50%
Apta_387	DNA	CTTTAATGCCCTTCACTAGGTCTAAGCTACTACTTACCCG	52.50%
Apta_852	DNA	CATCTGTGTGAAGACTATATGGCGCTCACATATTTCTTTC	52.50%
Apta_1287	DNA	GCCCGCATGCCGTCAAGCAATGTTAATCTTGTTTTGATTTCG	52.38%
Apta_943	DNA	GAAGGTGGAGCGGTTAGGATACTAGCGAATGAAGACACGTTAGCTGATCT	52.00%
Apta_1068	DNA	CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG	51.92%
Apta_60	DNA	GGAATGAGTGCCCTGCAAGCGAGGGCTAGC	51.28%
Apta_158	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG	51.28%
Apta_214	DNA	AGGAAGGCTTTAGGTTTCCTAAAGCCTTCC	51.28%
Apta_419	DNA	ATCAGGGCTAAAGAGTGCAGAGTTACTTAG	51.28%

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