Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1053
Aptamer sequence: TTATGTAGCATTTATGAAATTTTTAAATCAATTTACTATTGGTGGTATCC
Target unique ID: Other-41
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_970 | H3.17 | Other | HIV reverse transcriptase (HIV RT) | 0.38 nM | 20 mM Tris-HCl [pH 7.4], 140 mM NaCl, 5 mM KCl, 1 mM MgCl2, and 1 mM CaCl2 | 32298104 |
Structure information of aptamer
| Aptamer Sequence: | TTATGTAGCATTTATGAAATTTTTAAATCAATTTACTATTGGTGGTATCC |
| The optimal secondary structure in dot-bracket notation: | ....(((.((((.((((((((........)))))..))).)))).))).. |
| The centroid secondary structure in dot-bracket notation: | ....(((.(((......((((........))))........))).))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_970 | Description | H3.17 |
| Aptamer chemistry | DNA | Length | 50 nt |
| GC content | 24.0% | Molecular weight | 15,382.93 Da |
| Molarity of 1 μg/μl solution | 65.01 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Target recognition |
| Sequence | TTATGTAGCATTTATGAAATTTTTAAATCAATTTACTATTGGTGGTATCC | ||
| Applications | Binding to target proteins | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Target ID | Other-41 | Name | HIV reverse transcriptase (HIV RT) |
Activity data
 |
Interaction ID | 1053 |
| Target type | Other | |
| Target unique ID | Other-41 | |
| Activity | 0.38 nM | |
| Binding Conditions/Buffer | 20 mM Tris-HCl [pH 7.4], 140 mM NaCl, 5 mM KCl, 1 mM MgCl2, and 1 mM CaCl2 |
|
| Assay | MST binding affinity curves for the affinity aptamers |
|
| PubMed ID | 32298104 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_972 | DNA | TGACAGTACGTACTGAACTAATTTATAAGTAATTTGCTATGGTGGTATCC | |
| Apta_973 | DNA | TATGTAATGTTGACGTAATTTATCTCTGTGAGAATAAGCAGGTGGTATCC | |
| Apta_975 | DNA | AGACATAGTACATAACCGATCAATGAACATTTAATTAAATGGTGGTATCC | |
| Apta_976 | DNA | GATGAATATCGCAATGAAATTATATATGTATAATTGGAACGGTGGTATCC | |
| Apta_977 | DNA | CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC | |
| Apta_971 | DNA | TAGTCTAGGAACGGTACGATCGTATTCCAAGGACTTTGCTGGTGGTATCC | |
| Apta_974 | DNA | CATGGTGTCAATACTATACCTTTTGCCGATGGTAACAGTTGGTGGTATCC | |
| Apta_884 | DNA | ATACCAGCTTATTCAATTTGCACCACTTATTGTTACTAATCTGAGATAGTAAGTGCAATCT | |
| Apta_37 | DNA | TCTATAAACTCTGTCCGGTTTTATAATAATAACATTTTAC | |
| Apta_947 | DNA | CATGGCTAGGTGTTTATTAATCCTGTAGGATTTGCGGAAT | |
| Apta_740 | DNA | ATCGTCTGCTCCGTCCAATAAACCTGCATAATTTATAAGTCTAGACTGCTGCATTTGGTGTGAGGTCGTGC | |
| Apta_1154 | DNA | TTAATTTTTTGATCTTTGATTGTTTTATTTTTTTTATTGTTTGTG | |
| Apta_355 | DNA | GATGCAGCCACCTACATTGCAGGTTTTATAATACAACTACGCGCCGTTCGCAGGCTAGTT | |
| Apta_532 | DNA | ATCCGTCACACCTGCTCTAACTTACACATAATTCTAGGTTACATCTTGCTCATATGGTGTTGGCTCCCGTAT | |
| Apta_1280 | DNA | TCATATCCTTCTTGGTATCATTGCGTCATTTAGTCATTCATGTTATTCCCGAGGG | |
| Apta_734 | DNA | TCCTCGATGCACCAGTTCACCTTATTTGCTTCTTCTCTCTGTTCTGACTGGGTGCTGAGGA | |
| Apta_736 | DNA | ATCGTCTGCTCCGTCCAATATGATGACACCTGCATAATTTATAGTGAGTCTTGATTCACGCTGCATTTGGTGTGAGGTCGTGC | |
| Apta_49 | DNA | CTTCCATGTTGAGGCGTTTATACCAGTTATCATCGGACTA | |
| Apta_216 | DNA | TGGTTGGTTTTTGGTTTTTTTTTTTGGTTT | |
| Apta_349 | DNA | ATACCAGCTTATTCAATTAGACGAGTTTTATTCATTTTCCATGTCGTAGCTTACCGTGAGATAGTAAGTGCAATCT |
DEV TOOL
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