Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 453
Aptamer sequence: TAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCC
Target unique ID: Q15109
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_448 | clone 9 | Protein | RAGE_HUMAN | 1 μM | N/A | 17493639 |
Structure information of aptamer
| Aptamer Sequence: | TAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCC |
| The optimal secondary structure in dot-bracket notation: | .....................((((........................))))... |
| The centroid secondary structure in dot-bracket notation: | ........................................................ |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_448 | Description | clone 9 |
| Aptamer chemistry | DNA | Length | 56 nt |
| GC content | 46.4% | Molecular weight | 16,895.89 Da |
| Molarity of 1 μg/μl solution | 59.19 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted therapy |
| Sequence | TAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCC | ||
| Applications | Block toxic effects of AGE on cultured retinal pericytes | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | Q15109 | Protein name | Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) |
| Gene name(s) | AGER RAGE | Organism | Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) |
| Status | reviewed in uniprot database | Length | 404 |
| Mass | 42,803 | Activity regulation | N/A |
| Involvement in disease | N/A | Catalytic activity | N/A |
| PDB ID(s) | 2E5E;2ENS;2L7U;2LE9;2LMB;2M1K;2MJW;2MOV;3CJJ;3O3U;4LP4;4LP5;4OF5;4OFV;4OI7;4OI8;4P2Y;4XYN;4YBH;5D7F;6VXG;6XQ1;6XQ3;6XQ5;6XQ6;6XQ7;6XQ8;6XQ9;7LML;7LMW; |
 |
Function | Mediates interactions of advanced glycosylation end products (AGE). |
Activity data
|
No relevant experimental diagram |
Interaction ID | 453 |
| Target type | Protein | |
| Target unique ID | Q15109 | |
| Activity | 1 μM | |
| Binding Conditions/Buffer | N/A |
|
| Assay | N/A |
|
| PubMed ID | 17493639 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_872 | DNA | ACCGCCTTCCACCGTTCTCCACCACCCCTCAAACAACCCT | |
| Apta_439 | DNA | TAACACTCGATTCTCCTAGCCCGCTAGAAATTCCCCTCCC | |
| Apta_1266 | DNA | GCATCACACACCGATACTCACCCGCCTGATTAACATTAGCCCACCGCCCACCCCCGCTGC | |
| Apta_1111 | DNA | GTGCGTCGCATGATCGCGATTAGTGCGACCATGTACGATTCTCACGACAACGACACTGTACTTGAGGACTGTCTCC | |
| Apta_614 | DNA | AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT | |
| Apta_990 | DNA | AACCCAACCCCGCACCATTAGTCTAAATTTTCGCGACGGAACACAGCAACAACTCCCCA | |
| Apta_556 | DNA | GGCTCTCGGGACGACATGGATTTTCCATCAACGAAGTGCGTCCGTCCC | |
| Apta_777 | DNA | GAGCCCTATCTCACACCGCACCCGCAAACTATCATCCTACATG | |
| Apta_871 | DNA | CCAACCACACATCCTTCCATCGACATGGACCCACCGTTCC | |
| Apta_969 | DNA | TAACCACCCCACCTCGCTCCCGTGACACTAATGCTAATTCCAA | |
| Apta_1191 | DNA | TAATACTACCAACTTCTTTGCCTGGCGTAAGTAACAGTCA | |
| Apta_1214 | DNA | GTCCATTATTCTGGTAGCGTTGAACAACATTCAACACGCC | |
| Apta_321 | DNA | AACCGCCCAAATCCCTAAGAGTCGGACTGCAACCTATGCTATCGTTGATGTCTGTCCAAGCAACACAGACACACTACACACGCACA | |
| Apta_1007 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1103 | DNA | TACGACTCACTATAGGGATCCACCTATGGCAGATTGAGCCCAAGGGCTGTGCAGCGAATTCCCTTTAGTGAGGGTT | |
| Apta_952 | DNA | TCACCTCATACGACTCACTATAGCGGACCCCACTCACTGCTCGGACTCTCCCCCTCCCCGCCTGGCTCGAACAAGCTTGC | |
| Apta_1004 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCACTGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1005 | DNA | ATAGGAGTCGACCGACCAGACCCGACCTCTCCTTTCATGTGACACAATGGTGCGTCTACATCTAGACTC | |
| Apta_1009 | DNA | ATAGGAGTCGACCGACCAGACCAACCCTACGCTCGTACCAACCAGATGACCTACGTGGCGTCTACATCTAGACTC | |
| Apta_164 | DNA | TATAGACCACAGCCTGAGATTAACCACCAACCCAGGACT |
DEV TOOL
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