AptaDB: Result

Interaction ID: 380

Aptamer sequence: GUCCCGUGCGCAAAAGUUCUUAGCGCUAGCAGUCCUAGUUGC

Target unique ID: P26315

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_374	a.1.1	Protein	GAG_AVIMA	0.5 nM	50 mM Tris-HC1 (pH 7.7), 200 mM potassium acetate, and 10 mM DTT	7518691

Aptamer Sequence:	GUCCCGUGCGCAAAAGUUCUUAGCGCUAGCAGUCCUAGUUGC
The optimal secondary structure in dot-bracket notation:	.......((((...........))))..((((......))))
The centroid secondary structure in dot-bracket notation:	.......((((...........))))..(((........)))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_374	Description	a.1.1
Aptamer chemistry	RNA	Length	42 nt
GC content	54.8%	Molecular weight	13,398.95 Da
Molarity of 1 μg/μl solution	74.63 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	GUCCCGUGCGCAAAAGUUCUUAGCGCUAGCAGUCCUAGUUGC
Applications	Inhibition of cDNA synthesis and RNase H activity

Type	Detail	Type	Detail
Uniprot ID	P26315	Protein name	Proteinase p15 (EC 3.4.23.-)
Gene name(s)	gag	Organism	Proteinase p15 (EC 3.4.23.-)
Status	reviewed in uniprot database	Length	124
Mass	13,596	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	1MVP;
Function	Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor.

No relevant experimental diagram	Interaction ID	380
	Target type	Protein
	Target unique ID	P26315
	Activity	0.5 nM
	Binding Conditions/Buffer	50 mM Tris-HC1 (pH 7.7), 200 mM potassium acetate, and 10 mM DTT
	Assay	N/A
	PubMed ID	7518691

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_152	RNA	UUACCACGCGCUCUUAACUGCUAGCGCCAUGGC	59.52%
Apta_849	RNA	UCCCGAUUACUGUACAUACCUUAGCCCAUAGCUGGCUGC	54.76%
Apta_1167	RNA	GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC	54.76%
Apta_242	RNA	GCUUCCAGGAAGAGAAGUGUCAUGUGAUCAGUCCUGGUGGGUGG	54.55%
Apta_87	RNA	UACCGACUAGCAAAACCUGCUGGCGACGUUUAGAU	52.38%
Apta_293	RNA	CGGCCACAGAAUGAAAAACCUCAUCGAUGUUGCAUAGUUG	52.38%
Apta_588	RNA	CCGGUGCGCAUAACCACCUCAGUGCGAGCAAGGAA	52.38%
Apta_243	RNA	GCUUGAAGCUAGCAGUAAGACUAGCGCUACGGAUGGGUGUGCG	51.16%
Apta_381	RNA	AUUCUGUUGGCGAACUGUACGCAAGUACUGGAUGACAGCCUAUCUAU	51.06%
Apta_1121	RNA	GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC	51.06%
Apta_313	RNA	UGCCCUGCCCUCACCCGUUAGCCUGAGCGCCCCGCA	50.00%
Apta_367	RNA	CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC	50.00%
Apta_599	RNA	GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC	50.00%
Apta_603	RNA	CUUGUCUGAACAAUUUCGUCUGCCUUUGCGUUCCGACGGC	50.00%
Apta_647	RNA	GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC	50.00%
Apta_658	RNA	CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC	50.00%
Apta_712	RNA	GGCGGUGCUCGCCGAAAGGCUCCUGGAUACGUC	50.00%
Apta_717	RNA	GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC	50.00%
Apta_599	RNA	GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC	50.00%
Apta_647	RNA	GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC	50.00%

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