Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 761
Aptamer sequence: GCGCGAGAAACGGUCACUAGAAUAGUGGGCCGUCAUGCUAACGCCUCUUUCGGUGUUGGGGAAUAUUGGCCAAUCGAGU
Target unique ID: 6140
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1290 529 Molecule Phenylalanine 0.12 mM 50 mM Hepes (pH 7.0), 0.3 M NaCl, 5 mM CaCl2, and 5 mM MgCl2 11847556
Structure information of aptamer
Aptamer Sequence: GCGCGAGAAACGGUCACUAGAAUAGUGGGCCGUCAUGCUAACGCCUCUUUCGGUGUUGGGGAAUAUUGGCCAAUCGAGU
The optimal secondary structure in dot-bracket notation: ((.(((........(((((...)))))(((((.....((((((((......)))))))).......)))))..))).))
The centroid secondary structure in dot-bracket notation: .(.(((...((((.(((((...)))))..))))....((((((((......))))))))..............))).).
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1290 Description 529
Aptamer chemistry RNA Length 79 nt
GC content 53.2% Molecular weight 25,499.12 Da
Molarity of 1 μg/μl solution 39.22 μM Number of G-quadruplexes 1
G-Score 15 Function Targeted binding
Sequence GCGCGAGAAACGGUCACUAGAAUAGUGGGCCGUCAUGCUAACGCCUCUUUCGGUGUUGGGGAAUAUUGGCCAAUCGAGU
Applications Binding to phenylalanine
Target information
Type Detail Type Detail
PubChem ID 6140 Molecular name Phenylalanine
Molecular formula C9H11NO2 Molecular weight 165.19
IUPAC name (2S)-2-amino-3-phenylpropanoic acid InChIKey COLNVLDHVKWLRT-QMMMGPOBSA-N
LogP 0.641 Topological polar surface area 63.32
Hydrogen bond acceptor 2 Hydrogen bond donor 2

Synonym(s):
L-phenylalanine; phenylalanine; 63-91-2; (S)-2-Amino-3-phenylpropanoic acid; 3-Phenyl-L-alanine; (2S)-2-amino-3-phenylpropanoic acid; (S)-Phenylalanine; (S)-2-Amino-3-phenylpropionic acid; beta-Phenyl-L-alanine; (L)-Phenylalanine; 3-Phenylalanine; H-Phe-OH; Antibiotic FN 1636; L-Alanine, phenyl-; Alanine, 3-phenyl-; L-Antibiotic FN 1636; (S)-alpha-Amino-beta-phenylpropionic acid; L-Alanine, 3-phenyl-; Phenylalanine (VAN); Fenilalanina [Spanish]; Phenylalaninum [Latin]; (S)-alpha-Aminohydrocinnamic acid; Alanine, phenyl-, L-; (S)-(-)-Phenylalanine; beta-Phenylalnine, (-)-; (S)-alpha-Amino-benzenepropanoic acid; FEMA No. 3585; Phenylalanine, L-; Hydrocinnamic acid, alpha-amino-; 2-Amino-3-phenylpropionic acid, L-; Phenylalanine [USAN:INN:JAN]; HSDB 1825; alpha-Aminohydrocinnamic acid, L-; alpha-Amino-beta-phenylpropionic acid, L-; Benzenepropanoic acid, alpha-amino-, (S)-; fenilalanina; alpha-Aminohydrocinnamic acid; endophenyl; NSC 79477; L-Phe; UNII-47E5O17Y3R; L-PHENYLALININE; MFCD00064227; 67675-33-6; CHEMBL301523; CHEBI:17295; L-2-Amino-3-phenylpropionic acid; phe; 47E5O17Y3R; Phenylalaninum; phenylalanin; Phenylalamine; Phenylalanine (L-Phenylalanine); Alanine, phenyl-; .beta.-Phenylalanine; Phenyl-.alpha.-alanine; L-.beta.-Phenylalanine; .beta.-Phenyl-L-alanine; (-)-.beta.-Phenylalanine; EINECS 200-568-1; .alpha.-Aminohydrocinnamic acid; .beta.-Phenyl-.alpha.-alanine; Phenylalanine (USP/INN); L-phenylaniline; Hydrocinnamic acid, .alpha.-amino-; NSC-9959; CCRIS 4254; .beta.-Phenyl-.alpha.-alanine, l-; NSC-79477; L-phenyl Alanine; PheOH; 1usi; NCI9959; (-)-phenylalanine; .alpha.-Amino-.beta.-phenylpropionic acid; racemic phenylalanine; Phenylalanine [USAN:USP:INN:JAN]; 1f2p; alpha-Aminohydrocinnamate; (-)-beta-Phenylalanine; L-Phenylalanine, 99%; beta-Phenyl-alpha-alanine; L-Phenylalanine (JP17); bmse000045; bmse000900; bmse000921; bmse001016; SCHEMBL8119; NCIStruc1_000204; NCIStruc2_000248; H-Phe-2-Chlorotrityl Resin; L-(-)-PHENYLALANINE; (S)-alpha-Aminohydrocinnamate; L-Phenylalanine (H-Phe-OH); L-2-Amino-3-phenylpropionate; L-Phenylalanine, 99%, FCC; GTPL3313; (S)-alpha-Aminobenzenepropanoate; 3-Amino-4-phenyl-butanoic acid; DTXSID4040763; (S)-2-amino-3-phenylpropanoate; BDBM18073; (S)-2-Amino-3-phenylpropionate; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; L-Phenylalanine non-animal source; (S)-alpha-Amino-benzenepropanoate; ZINC105196; HY-N0215; L-2-amino-3-phenyl-propionic acid; (S)-alpha-Aminobenzenepropanoic acid; AC8117; CCG-37572; NCGC00013103; L-[2,3,4,5,6-3H]phenylalanine; (S)-alpha-Amino-beta-phenylpropionate; AKOS010373257; AKOS015853585; L-Phenylalanine, Cell Culture Reagent; (S)-.alpha.-Aminobenzenepropanoic acid; DB00120; L-Phenylalanine, Vetec(TM), 98.5%; MCULE-5960921520; L-Phenylalanine, reagent grade, >=98%; NCGC00013103-02; NCGC00013103-03; NCGC00013103-04; NCGC00013103-05; NCGC00095047-01; NCGC00095047-02; NCGC00095047-03; NCGC00095047-04; AC-22417; AS-14129; BP-20538; K018; AB0013977; DB-029978; L-Phenylalanine, 99%, natural, FCC, FG; AM20060774; P0134; Benzenepropanoic acid, .alpha.-amino-, (S)-; L-Phenylalanine, BioUltra, >=99.0% (NT); 63P912; A20654; C00079; D00021; M02961; 34149-EP2289892A1; 34149-EP2301939A1; 34149-EP2305688A1; 34149-EP2305825A1; 34149-EP2311850A1; L-Phenylalanine, SAJ special grade, >=99.0%; 125851-EP2284178A2; 125851-EP2284179A2; 125851-EP2295422A2; Q170545; L-Phenylalanine, Vetec(TM) reagent grade, >=98%; Q-201326; F0001-2360; Z1258578341; L-Phenylalanine, certified reference material, TraceCERT(R); UNII-0O72R8RF8A component COLNVLDHVKWLRT-QMMMGPOBSA-N; UNII-8P946UF12S component COLNVLDHVKWLRT-QMMMGPOBSA-N; UNII-N7U7BXP2OI component COLNVLDHVKWLRT-QMMMGPOBSA-N; Phenylalanine, European Pharmacopoeia (EP) Reference Standard; 3-(2-AMINOETHYL)-1,3-THIAZOLIDINE-2,4-DIONEHYDROCHLORIDE; L-Phenylalanine, United States Pharmacopeia (USP) Reference Standard; L(-)-phenylalanine; Beta-phenylalanine;Dl-2-amino-3-phenylpropanoic acid;; L-Phenylalanine, analytical standard, for Nitrogen Determination According to Kjeldahl Method; L-Phenylalanine, Pharmaceutical Secondary Standard; Certified Reference Material; L-Phenylalanine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%; L-Phenylalanine, PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture

Activity data
Interaction ID 761
Target type Molecule
Target unique ID 6140
Activity 0.12 mM
Binding Conditions/Buffer

50 mM Hepes (pH 7.0), 0.3 M NaCl, 5 mM CaCl2, and 5 mM MgCl2

Assay

N/A

PubMed ID 11847556
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_224 RNA GGGGCCACCAACGACAUUGAACCACGUAGGCUCGUUUCUGAGCCGAUCUCGAUGUUGAUAUAAAUAGUGCCCAUGGAUC 56.96%
Apta_576 RNA GGCACCAAAGCUGAAGUAGCGGGAUAACUCAAAUUACUUUAGGUGUAUGAAGGUGAAACUAGCAAUGAA 54.43%
Apta_414 RNA GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA 53.75%
Apta_225 RNA GGGGCCACCAACGACAUUUAUCGAAUUGAUAACCUUACGCGAGAGCGUAGUUCGUUGAUAUAAAUAGUGCCCAUGGAUC 53.16%
Apta_276 RNA GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC 52.94%
Apta_575 RNA AGAGCUUGACGGUCCCGAGAGUCGAGCCCAAGCUGACACUGGACCUUUGCGGACCACGUGUUGAUCGUCG 51.90%
Apta_984 RNA GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA 51.90%
Apta_1053 RNA GCCGCAAGUACGAGGGCGGCGCGCUCGACGCGGUUAGAUGAGUGUCGCCGUUUCCGAAGAUUGGCUACGCGGGG 51.90%
Apta_816 RNA GGGUUCACUGCAGACUUGACGAAGCUUGAGAGAUGCCCCCUGAUGUGCAUUCUUGUUGUGUUGCGGCAAUGGAUCCACAUCUACGAAUUC 51.11%
Apta_352 RNA GGGAGGACGAUGCGGUGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGGCAGACGACUCGCCCGA 50.63%
Apta_1124 RNA GGGCGAAUUCGGGUUGGAUAGUAGGCGCAUAUGGCAUCUUCGUGGUUGUGUAUUGCCCUUUAGUGAGGGUUAAUU 50.63%
Apta_1168 RNA GCGACUACGGUGAGGGUCGGGUCCAGUAGCUUCGGCUACUGUUGAGUAGAGUGUGGGCUCCGUAGUCGC 50.63%
Apta_720 RNA GGGAGAAUUCCGACCAGAAGCUUAGUAUAGCGAGGUUUAGCUACACUCGUGCUGAUCGUUUGGUACGGGACCUGCGUGUAGCCCAUAUGUGCGUCUACAUGGAUCCUCA 50.46%
Apta_123 RNA GGGAGAAAGGGAAGCUUGAGCAGCAGGAGGGCCGGCGUUAGGGUUAGCGAGCCGAUUGAAAGAAGAAGGAACGAGCGUACGGAUCCGAUC 50.00%
Apta_1225 RNA GGAGGCGCCAACUGAAUGAAAGAGGUAACGAAAGAUGAUUGUGCCUGCUUCGGCAGUACAACUUCUCGGAUAAAUGAUUAUCCGUAACUAGUCGCGUCAC 50.00%
Apta_413 RNA GUGAGACCAGCCGAGUGGUGUCUGGCUAUUCACUGGAGCGUGGGUGGAACCCCUGCGCACUCGUUUGGCUGUCCGGGCCUUCGGGCCGGGAUUAUCUCU 49.49%
Apta_724 RNA GGGAGAGGAUACUACUGUCAUACGUUAGGCUGUAGGCGAGGUGAAAUGAGCGGUAAUAGCCUCAGCGUAGCAUAUGCAUGAAUUCGAAGCUUCGC 49.47%
Apta_854 RNA GGGAGCUCAGAAUAAACGCUCAAGGGUAGGGAUCGUUACCCCGACAUUUUAAUGGGCCGAUGUUUCGACAUGAGGCCCGGAUCCGGC 49.43%
Apta_410 RNA GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGG 49.41%
Apta_428 RNA GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA 49.40%