Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 123
Aptamer sequence: AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA
Target unique ID: P01303
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_110 6.26 Protein NPY_HUMAN 1.1 μM 20 mM Hepes (pH 7.3) with 10 mM NaCl 15984861
Structure information of aptamer
Aptamer Sequence: AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA
The optimal secondary structure in dot-bracket notation: (((((((...((((..(((((.......(((...........)))......)))))...)))).))).))))........
The centroid secondary structure in dot-bracket notation: ((((((....((((..(((((..............................)))))...))))..)).))))........
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_110 Description 6.26
Aptamer chemistry DNA Length 80 nt
GC content 52.5% Molecular weight 25,121.88 Da
Molarity of 1 μg/μl solution 39.81 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA
Applications Binding to target proteins
Target information
Type Detail Type Detail
Uniprot ID P01303 Protein name Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
Gene name(s) NPY Organism Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
Status reviewed in uniprot database Length 97
Mass 10,851 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
1QFA;1RON;7RTA;7VGX;
Function NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Activity data

No relevant experimental diagram

 Interaction ID 111
Target type Protein
Target unique ID P01298
Activity 7 μM
Binding Conditions/Buffer

20 mM Hepes (pH 7.3) with 10 mM NaCl
Assay

N/A
PubMed ID 15984861

No relevant experimental diagram

 Interaction ID 123
Target type Protein
Target unique ID P01303
Activity 1.1 μM
Binding Conditions/Buffer

20 mM Hepes (pH 7.3) with 10 mM NaCl
Assay

N/A
PubMed ID 15984861
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_110 DNA AGCAGCACAGAGGTCAGATGGTTAGGAAGGTGAATAGGTACGACTGCAGGTCTATCGCAGCCTATGCGTGCTACCGTGAA
100.00%
Apta_174 DNA AGCAGCACAGAGGTCAGATGTCGGTCTTGTGTATACATACCCGTGTGTTTTCATCTCAGGCCTATGCGTGCTACCGTGAA 75.00%
Apta_175 DNA AGCAGCACAGAGGTCAGATGAGGACTGTCGATAAGTATAATGGCAAGTAGCTCGATACATCCTATGCGTGCTACCGTGAA 75.00%
Apta_101 DNA AGCAGCACAGAGGTCAGATGTGTTAGGCTGGGACACGTATTACACTTACCGTAAATATTTCCTATGCGTGCTACCGTGAA 73.75%
Apta_104 DNA AGCAGCACAGAGGTCAGATGCAAACCACAGCCTGAGTGGTTAGCGTATGTCATTTACGGACCTATGCGTGCTACCGTGAA 73.75%
Apta_106 DNA AGCAGCACAGAGGTCAGATGGAGCCAGGAGTCGGCCTACAGAAGATTCTGATGTACCTCACCTATGCGTGCTACCGTGAA 73.75%
Apta_104 DNA AGCAGCACAGAGGTCAGATGCAAACCACAGCCTGAGTGGTTAGCGTATGTCATTTACGGACCTATGCGTGCTACCGTGAA 73.75%
Apta_101 DNA AGCAGCACAGAGGTCAGATGTGTTAGGCTGGGACACGTATTACACTTACCGTAAATATTTCCTATGCGTGCTACCGTGAA 73.75%
Apta_106 DNA AGCAGCACAGAGGTCAGATGGAGCCAGGAGTCGGCCTACAGAAGATTCTGATGTACCTCACCTATGCGTGCTACCGTGAA 73.75%
Apta_61 DNA AGCAGCACAGAGGTCAGATGGCAGGTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGCCCTATGCGTGCTACCGTGAA 72.50%
Apta_102 DNA AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA 72.50%
Apta_102 DNA AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA 72.50%
Apta_173 DNA AGCAGCACAGAGGTCAGATGGCAGGTTTCGACGTACAATGCTATGGAGGCTTTATGATCGCCTATGCGTGCTACCGTGAA 72.50%
Apta_176 DNA AGCAGCACAGAGGTCAGATGTATGGTACATTCGAGCGAGCTAAACTAGGATTAAACTCACCCTATGCGTGCTACCGTGAA 72.50%
Apta_177 DNA AGCAGCACAGAGGTCAGATGCCATAGGTGCCTGAATTGTCCCAAACATTCGCATGATCGACCTATGCGTGCTACCGTGAA 72.50%
Apta_235 DNA AGCAGCACAGAGGTCAGATGTGGTTCGATGCTGCAAGGTGTTGTCATTTGGCATATGTTACCTATGCGTGCTACCGTGAA 72.50%
Apta_99 DNA AGCAGCACAGAGGTCAGATGTCGGGCGGTTCGGGACCTTGCTGCGACATATGCGTATTATCCTATGCGTGCTACCGTGAA 71.25%
Apta_100 DNA AGCAGCACAGAGGTCAGATGATTCAAGGGTAACACATCCAGGGGAACGGAATTGCAGCCCCCTATGCGTGCTACCGTGAA 71.25%
Apta_105 DNA AGCAGCACAGAGGTCAGATGATGCTCTAGGCGAAAGACTTGGCGTAGAACGACGGGAGGCCCTATGCGTGCTACCGTGAA 71.25%
Apta_107 DNA AGCAGCACAGAGGTCAGATGTTCATTTCAGTTGACCGATAGCATTGAGCAATGATCTATTCCTATGCGTGCTACCGTGAA 71.25%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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