AptaDB: Result

Interaction ID: 225

Aptamer sequence: GTCCTAGCAGACACTCGGCCATCACGCCCATTGGTTTGCA

Target unique ID: P05121

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_221	R9chWT-1	Protein	PAI1_HUMAN	1.2 nM	20 mM HEPES (pH 7.4), 50 mM NaCl, 2 mM CaCl2, and 0.1% BSA	19284310

Aptamer Sequence:	GTCCTAGCAGACACTCGGCCATCACGCCCATTGGTTTGCA
The optimal secondary structure in dot-bracket notation:	......((((((....(((......))).....)))))).
The centroid secondary structure in dot-bracket notation:	......((((((....(((......))).....)))))).

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_221	Description	R9chWT-1
Aptamer chemistry	DNA	Length	40 nt
GC content	57.5%	Molecular weight	12,432.77 Da
Molarity of 1 μg/μl solution	80.43 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	GTCCTAGCAGACACTCGGCCATCACGCCCATTGGTTTGCA
Applications	Adjuvant to traditional chemotherapy for breast cancer

Type	Detail	Type	Detail
Uniprot ID	P05121	Protein name	Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
Gene name(s)	SERPINE1 PAI1 PLANH1	Organism	Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
Status	reviewed in uniprot database	Length	402
Mass	45,060	Activity regulation	N/A
Involvement in disease	Plasminogen activator inhibitor-1 deficiency (PAI-1D)	Catalytic activity	N/A
PDB ID(s)	1A7C;1B3K;1C5G;1DB2;1DVM;1DVN;1LJ5;1OC0;3CVM;3EOX;3PB1;3Q02;3Q03;3R4L;3UT3;4AQH;4G8O;4G8R;4IC0;5BRR;5ZLZ;6GWN;6GWP;6GWQ;6I8S;6ZRV;7AQF;7AQG;9PAI;
Function	Serine protease inhibitor. Inhibits TMPRSS7.

No relevant experimental diagram	Interaction ID	225
	Target type	Protein
	Target unique ID	P05121
	Activity	1.2 nM
	Binding Conditions/Buffer	20 mM HEPES (pH 7.4), 50 mM NaCl, 2 mM CaCl2, and 0.1% BSA
	Assay	N/A
	PubMed ID	19284310

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_728	DNA	CGACCCGGCACAAACCCAGAACCATATACACGATCATTAGTCTCCTGGGCCG	55.77%
Apta_358	DNA	GGGAATCGCCACCCGACGCAGGGTTTCCC	55.00%
Apta_437	DNA	TCACAGTCCCGGTGCCGCACTAAAACCCATTGTTGTGCGA	55.00%
Apta_817	DNA	TGCGTGAGCGGTAGGCCCCTACGACCCACTGTGGTTGGGC	55.00%
Apta_875	DNA	GCCGCGACCATACAACGCAAACAACACGCCTGTACGCTTG	55.00%
Apta_877	DNA	GTGCGAAGCGCCTCCACTGTACATCCACTCCTTCTGCC	55.00%
Apta_1149	DNA	ATCATGGTGGGTATCGGCACTCGTTGGTTGAT	55.00%
Apta_1215	DNA	GTCGAATCAGCACCTCTGCATAGGTTACGTTTATACTGCG	55.00%
Apta_665	DNA	CGCCAATCTCAAAGCCCGCCACCTGCCCCTCACTGCCCACCTGTGGAATCCATGTCGCTC	53.33%
Apta_1172	DNA	GACGCCACTGACTACCCCAGTATCTCTTCAACGCGTATTGAAGTCAGTCGGTCGTCA	52.63%
Apta_56	DNA	GCAGCTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC	52.50%
Apta_159	DNA	GCGTGCAGCATGACCACCGATGTCACACTTAATGAGAAT	52.50%
Apta_252	DNA	CCCTTACCTACTCTGCTCCCCCCCCCCCTCGGCTGC	52.50%
Apta_253	DNA	CCCTGTTCGCTATCCCCCATCCCCCGATTGC	52.50%
Apta_360	DNA	GGGAACGCATACGCCGCAGTATTTCCC	52.50%
Apta_362	DNA	GGGAACGCACCGATCGCAGGTTTCCC	52.50%
Apta_1282	DNA	TCCTCTCACACATCTTATCCCCTAGGG	52.50%
Apta_340	DNA	TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA	52.27%
Apta_395	DNA	AATCCACGTATCGACTAGCTCAAACCAGCCTGATAGAGCCATTCGCTTTA	52.00%
Apta_1046	DNA	TCGCATGGAGGGCAGAGCCGCCTGCCGGGATCCGGCCCTCTTGGGCGGGC	52.00%

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