Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 517
Aptamer sequence: ATACGGGAGCCAACACCATGTACATTGTAGATTTATTTGCCCAAAACCCAAGAAGAGCAGGTGTGACGGAT
Target unique ID: 186907
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1049 APB3 Molecule Aflatoxin B1 221.2 nM 20 mM Tris-HCl, 100 mM NaCl, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2 24984866
Structure information of aptamer
Aptamer Sequence: ATACGGGAGCCAACACCATGTACATTGTAGATTTATTTGCCCAAAACCCAAGAAGAGCAGGTGTGACGGAT
The optimal secondary structure in dot-bracket notation: .........((.(((((.(((.....(((((....)))))................))))))))...))..
The centroid secondary structure in dot-bracket notation: .........((.(((((.(((...................................))))))))...))..
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1049 Description APB3
Aptamer chemistry DNA Length 71 nt
GC content 45.1% Molecular weight 21,952.13 Da
Molarity of 1 μg/μl solution 45.55 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence ATACGGGAGCCAACACCATGTACATTGTAGATTTATTTGCCCAAAACCCAAGAAGAGCAGGTGTGACGGAT
Applications Recognition of aflflatoxin B1
Target information
Type Detail Type Detail
PubChem ID 186907 Molecular name Aflatoxin B1
Molecular formula C17H12O6 Molecular weight 312.27
IUPAC name (3S,7R)-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione InChIKey OQIQSTLJSLGHID-WNWIJWBNSA-N
LogP 2.277 Topological polar surface area 74.97
Hydrogen bond acceptor 6 Hydrogen bond donor 0

Synonym(s):
AFLATOXIN B1; 1162-65-8; AFB1; UNII-9N2N2Y55MH; NSC-529592; 1H,11H-Cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)-; AFBI; 9N2N2Y55MH; CHEBI:2504; 2,3,6aalpha,9aalpha-Tetrahydro-4-methoxycyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione; MFCD00869647; (6aR,9aS)-4-methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene-1,11-dione; Aflatoxin B; (3S,7R)-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione; NSC 529592; HSDB 3453; NSC529592; CCRIS 12; Aflatoxin B1 2 microg/mL in Acetonitrile; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR,9aS)-; EINECS 214-603-3; BRN 1269174; Aflatoxin B1 from Aspergillus flavus, from Aspergillus flavus; (+/-)-Aflatoxin B1; BIDD:ER0313; SCHEMBL126480; Aflatoxin B1 Standard Solution; CHEMBL1697694; DTXSID9020035; Aflatoxin B1, reference material; DTXSID00873175; BDBM120261; ZINC402671; AMY22311; EX-A5480; HY-N6615; AKOS030241596; VA10187; NCGC00247669-01; 2,3,6aalpha,9aalpha-Tetrahydro-4-methoxycyclopenta(c)furo(2',3':4,5)furo(2,3-h)chromene-1,11-dione; Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6aalpha,9aalpha-tetrahydro-4-methoxy-; CS-0034371; 162A658; Q4689278; WLN: T F5 C6 B655 DOV GV OO QO RUT&&TTJ LO1; Aflatoxin B1 solution, 20 mug/mL in methanol, analytical standard; Aflatoxin B1 solution, 2 mug/mL in acetonitrile, analytical standard; Aflatoxin B1 solution, 3 mug/mL in benzene:acetonitrile (98:2), analytical standard; Aflatoxin B1 solution, 3.79 mug/g in acetonitrile, ERM(R) certified Reference Material; Aflatoxin B1 solution, certified reference material, 20 mug/mL in methanol, ampule of 1 mL; 10279-73-9; Aflatoxin B1 solution, certified reference material, 3 mug/mL in benzene:acetonitrile (98:2), ampule of 1 mL; Cyclopenta[c]furo[3',5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-; Cyclopenta[c]furo[3',5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-; Cyclopenta[c]furo[3',5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a.alpha.,9a.alpha.-tetrahydro-4-methoxy-

Activity data

No relevant experimental diagram

 Interaction ID 517
Target type Molecule
Target unique ID 186907
Activity 221.2 nM
Binding Conditions/Buffer

20 mM Tris-HCl, 100 mM NaCl, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2
Assay

N/A
PubMed ID 24984866
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_954 DNA ATACGGGAGCCAACACCAGGACTAACATTATAAGAATTGCGAATAATCATTGGAGAGCAGGTGTGACGGAT 74.65%
Apta_527 DNA ATACGGGAGCCAACACCAACAACCTAGATGTTCTGATAACACGAATCGCTTCGAAGAGCAGGTGTGACGGAT 73.61%
Apta_902 DNA ATACGGGAGCCAACACCACCAACATTATCAGAGTATGTTACTTATAGTGGTGGCAGAGCAGGTGTGACGGAT 73.61%
Apta_824 DNA ATACGGGAGCCAACACCATCCCTCTTAGGATACAAAGCCAAACTGAGCCCGTGCAGAGCAGGTGTGACGGAT 72.22%
Apta_896 DNA ATACGGGAGCCAACACCATAAGTCTAAAAAACTGGGAGTAAACACAATGTGTATAGAGCAGGTGTGACGGAT 70.83%
Apta_897 DNA ATACGGGAGCCAACACCACTCTTATTTCCGGAAGTGGTTCTTCAACAGAGGAATAGAGCAGGTGTGACGGAT 69.44%
Apta_898 DNA ATACGGGAGCCAACACCAACAAAACTAGCAAATTAGAGCCGTATCGGAGCCTATAGAGCAGGTGTGACGGAT 69.44%
Apta_526 DNA ATACGGGAGCCAACACCAAGTAACACACGCGGACCAGAAATACATCCCCCCGTAGAGCAGGTGTGACGGAT 69.01%
Apta_903 DNA ATACGGGAGCCAACACCAGACGGTAAATAAAGTCAGTATCGATACTCTATTCGAGAGCAGGTGTGACGGAT 69.01%
Apta_901 DNA ATACGGGAGCCAACACCACAAGTTGACTTGGAGGAGGGTCTAACTAGTTCGAGGAGAGCAGGTGTGACGGAT 68.06%
Apta_904 DNA ATACGGGAGCCAACACCAGACGGTAAATAAAGTCAGTATCGAGTACTCTATTCGAGAGCAGGTGTGACGGAT 68.06%
Apta_907 DNA ATACGGGAGCCAACACCACAACAAGATAAAGTATCAATCTGGTTGACGGACGTGAGAGCAGGTGTGACGGAT 68.06%
Apta_1048 DNA ATACGGGAGCCAACACCACCTGCGGAAAATCAACAACGACACACGCCACGATTCAGAGCAGGTGTGACGGAT 68.06%
Apta_533 DNA ATACGGGAGCCAACACCAAAGTAAGATCATCACCCGGACGCGGACATAATAGGAGAGCAGGTGTGACGGAT 67.61%
Apta_533 DNA ATACGGGAGCCAACACCAAAGTAAGATCATCACCCGGACGCGGACATAATAGGAGAGCAGGTGTGACGGAT 67.61%
Apta_908 DNA ATACGGGAGCCAACACCAATTCCGCCAAAGTCTGCTAATAAACGGACGCCGGGGAGAGCAGGTGTGACGGAT 66.67%
Apta_528 DNA ATACGGGAGCCAACACCACTTGGTTAACCAATCAAACCGGACAACGAAGGGTCCAGAGCAGGTGTGACGGAT 65.28%
Apta_531 DNA ATACGGGAGCCAACACCACATCGACTTACGAATCAACGCGTTTATTATTGGTTCAGAGCAGGTGTGACGGAT 65.28%
Apta_827 DNA ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCCAGGGGCCCCGTCTCTGAGAGCAGGTGTGACGGAT 65.28%
Apta_825 DNA ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCCAGGGACCCCGTCTCTGAGAGCAGGTGTGACGGAT 63.89%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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