Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1048
Aptamer sequence: CACGGCATGTGTGGCCGGATGCCTATATCGGTCGACTGCA
Target unique ID: P01266
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_965 | T-8 | Protein | THYG_HUMAN | 12.31 μM | TGK, Tris-HCl, BBS, and PBS | 33303143 |
Structure information of aptamer
| Aptamer Sequence: | CACGGCATGTGTGGCCGGATGCCTATATCGGTCGACTGCA |
| The optimal secondary structure in dot-bracket notation: | ....(((.((.((((((.(((....)))))))))))))). |
| The centroid secondary structure in dot-bracket notation: | ....(((.((.((((((.((......))))))))))))). |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_965 | Description | T-8 |
| Aptamer chemistry | DNA | Length | 40 nt |
| GC content | 60.0% | Molecular weight | 12,328.90 Da |
| Molarity of 1 μg/μl solution | 81.11 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | CACGGCATGTGTGGCCGGATGCCTATATCGGTCGACTGCA | ||
| Applications | CE-based detection validated the application feasibility of aptamer for Tg detection | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P01266 | Protein name | Thyroglobulin (Tg) |
| Gene name(s) | TG | Organism | Thyroglobulin (Tg) |
| Status | reviewed in uniprot database | Length | 2768 |
| Mass | 304,790 | Activity regulation | N/A |
| Involvement in disease | Thyroid dyshormonogenesis 3 (TDH3) | Catalytic activity | N/A |
| PDB ID(s) | 6SCJ;7B75; |
 |
Function | Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). |
Activity data
|
No relevant experimental diagram |
Interaction ID | 1048 |
| Target type | Protein | |
| Target unique ID | P01266 | |
| Activity | 12.31 μM | |
| Binding Conditions/Buffer | TGK, Tris-HCl, BBS, and PBS |
|
| Assay | N/A |
|
| PubMed ID | 33303143 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_635 | DNA | TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAACCCCCCA | |
| Apta_636 | DNA | TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAGCCCCCCA | |
| Apta_637 | DNA | TAGCCGGATCGCGTTGGCCAGATGATATAAAGGGTCAACCCCCCA | |
| Apta_638 | DNA | TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAACCCCCCG | |
| Apta_1018 | DNA | ATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGG | |
| Apta_183 | DNA | TAGCACTGTGCGGCGCGTATTGTTCTAATCTGATTACATT | |
| Apta_253 | DNA | CCCTGTTCGCTATCCCCCATCCCCCGATTGC | |
| Apta_543 | DNA | GGCACGTGTTGTCTCTCTGTGTCTCGTGCC | |
| Apta_648 | DNA | GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGC | |
| Apta_850 | DNA | CACCAGTGTGTTGAGGTTTGAGCACACTGATAGAGTGTCA | |
| Apta_958 | DNA | CGCGTGAGCGGGGAGGCGATGCCCAGGCTAACTTGACTCA | |
| Apta_962 | DNA | CCACACCGAGATGTTGTGACGGTTCCGATTGGCAAACTGA | |
| Apta_1013 | DNA | ATCACGTATGGGGGGCCGGCATGAGGGCCGCGCGTGACA | |
| Apta_1040 | DNA | CAATTGGGCCCGTCCGTATGGTGGGT | |
| Apta_1204 | DNA | GGCACGATGTGGCTACATCGATCGCGGTACTGGTG | |
| Apta_1204 | DNA | GGCACGATGTGGCTACATCGATCGCGGTACTGGTG | |
| Apta_1126 | DNA | TCGGGCGAGTCGTCTGCGGGCGGATAGACTACGACACCGCATCGTCCTCCC | |
| Apta_571 | DNA | ACCTGCGATAGGTAGTTTGTTTCTGTTGCCCTAGCGTCCGTCGTAACAAGTCA | |
| Apta_910 | DNA | TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA | |
| Apta_1043 | DNA | TTCAAGGCGGCGAGATTTAGTGGTTGGGAGGCTGTACGCCCTACGTGAAC |
DEV TOOL
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