AptaDB: Result

Interaction ID: 398

Aptamer sequence: GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT

Target unique ID: P40259

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_392	TD05.18	Protein	CD79B_HUMAN	819 nM	RPMI 1640, 4.5 g/L glucose, 5 mM MgCl2 in vivo (20 mM MgCl2 in vitro), 100 mg/L tRNA and 100 mg/L BSA	21030439

Aptamer Sequence:	GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT
The optimal secondary structure in dot-bracket notation:	((((((((....))))))))(((....)))...
The centroid secondary structure in dot-bracket notation:	(((((((......))))))).............

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_392	Description	TD05.18
Aptamer chemistry	DNA	Length	33 nt
GC content	57.6%	Molecular weight	10,158.50 Da
Molarity of 1 μg/μl solution	98.44 μM	Number of G-quadruplexes	2
G-Score	17	Function	Targeted binding
Sequence	GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT
Applications	Improved kinetic and biochemical features, unique specificity and desirable pharmacological properties, may be useful in biomedical applications

Type	Detail	Type	Detail
Uniprot ID	P40259	Protein name	B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
Gene name(s)	CD79B B29 IGB	Organism	B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
Status	reviewed in uniprot database	Length	229
Mass	26,048	Activity regulation	N/A
Involvement in disease	Agammaglobulinemia 6, autosomal recessive (AGM6)	Catalytic activity	N/A
PDB ID(s)	3KG5;
Function	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation.

No relevant experimental diagram	Interaction ID	398
	Target type	Protein
	Target unique ID	P40259
	Activity	819 nM
	Binding Conditions/Buffer	RPMI 1640, 4.5 g/L glucose, 5 mM MgCl2 in vivo (20 mM MgCl2 in vitro), 100 mg/L tRNA and 100 mg/L BSA
	Assay	N/A
	PubMed ID	21030439

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_393	DNA	AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	89.19%
Apta_391	DNA	ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT	73.33%
Apta_729	DNA	AACACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCCGGTG	68.75%
Apta_73	DNA	GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC	60.61%
Apta_74	DNA	GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC	60.61%
Apta_124	DNA	GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC	60.61%
Apta_69	DNA	AGCGAGTAGGTTGGTGTGGTTGGGGCTCGCT	57.58%
Apta_71	DNA	GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC	57.58%
Apta_542	DNA	GCACGTGTTGTCTCTCTGTGTCTCGTGC	57.58%
Apta_543	DNA	GGCACGTGTTGTCTCTCTGTGTCTCGTGCC	57.58%
Apta_915	DNA	ACTTCGGCTAGTTAGGGGGTAGTTTAGATCGTCTCTACAT	57.50%
Apta_1093	DNA	AGGAGGGTAGGTAGTGCTTGGTAGGGAAACTCCGCCGATT	57.50%
Apta_1256	DNA	GATCGGGTGTGGGTGGCGTAAAGGGAGCATCGGACA	55.56%
Apta_1176	DNA	AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT	55.26%
Apta_263	DNA	AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC	55.00%
Apta_443	DNA	GGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA	55.00%
Apta_911	DNA	GGCCATTGTGGACTTCTTTGGGTAATTCAGGGGCTCGATT	55.00%
Apta_959	DNA	GGACCGCTAGGTTCGTGGCTGAGATCACGCGATATCAGTA	55.00%
Apta_197	DNA	GGCTTTAGGTCTGAGATCTCGGAAT	54.55%
Apta_329	DNA	GGCGTACGGTAGGCGGGGTCAACTG	54.55%

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