AptaDB: Result

Interaction ID: 443

Aptamer sequence: TCACAGTCCCGGTGCCGCACTAAAACCCATTGTTGTGCGA

Target unique ID: Q13651

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_437	402	Protein	I10R1_HUMAN	120 nM	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)	26007661

Aptamer Sequence:	TCACAGTCCCGGTGCCGCACTAAAACCCATTGTTGTGCGA
The optimal secondary structure in dot-bracket notation:	.(((.......))).(((((..............))))).
The centroid secondary structure in dot-bracket notation:	.(((.......))).(((((..............))))).

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_437	Description	402
Aptamer chemistry	DNA	Length	40 nt
GC content	55.0%	Molecular weight	12,216.85 Da
Molarity of 1 μg/μl solution	81.85 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	TCACAGTCCCGGTGCCGCACTAAAACCCATTGTTGTGCGA
Applications	Bind human receptors and cross-react with their murine orthologs

Type	Detail	Type	Detail
Uniprot ID	Q13651	Protein name	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Gene name(s)	IL10RA IL10R	Organism	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Status	reviewed in uniprot database	Length	578
Mass	63,003	Activity regulation	N/A
Involvement in disease	Inflammatory bowel disease 28, autosomal recessive (IBD28)	Catalytic activity	N/A
PDB ID(s)	1J7V;1LQS;1Y6K;1Y6M;1Y6N;5IXI;6X93;
Function	Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

No relevant experimental diagram	Interaction ID	443
	Target type	Protein
	Target unique ID	Q13651
	Activity	120 nM
	Binding Conditions/Buffer	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)
	Assay	N/A
	PubMed ID	26007661

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_817	DNA	TGCGTGAGCGGTAGGCCCCTACGACCCACTGTGGTTGGGC	57.50%
Apta_821	DNA	CACAGTCACTCAGACGGCCGCTATTGTTGCCAGATTGCCTTTGGC	55.56%
Apta_56	DNA	GCAGCTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC	55.00%
Apta_221	DNA	GTCCTAGCAGACACTCGGCCATCACGCCCATTGGTTTGCA	55.00%
Apta_1263	DNA	CCCCGCTGCCCGTGTTCCGTCCTCCCTTGCTGTGTGTGCG	55.00%
Apta_938	DNA	TTGCCCACCTCCCTGTGCGGGCCACAGAGCAGCAGTGTCGTG	54.76%
Apta_641	DNA	TTCAAGACGATGCCTGGCGCGAGTTACACACTTGCATGGAGCTGG	53.33%
Apta_644	DNA	TCAATCTAACCATGCATGCAGTTTAGGCAGGATTCGTTATCGCAA	53.33%
Apta_993	DNA	AATCCGACCACGAGAGCAGACCGACCACAGCATTATCTAAACCCATTAGTCTAGTCCTGG	53.33%
Apta_1126	DNA	TCGGGCGAGTCGTCTGCGGGCGGATAGACTACGACACCGCATCGTCCTCCC	52.94%
Apta_7	DNA	CCAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC	52.50%
Apta_1067	DNA	GCGCGGTACCGCGCTAACGGAGGTTGCGTCCGT	52.50%
Apta_972	DNA	TGACAGTACGTACTGAACTAATTTATAAGTAATTTGCTATGGTGGTATCC	52.00%
Apta_815	DNA	CATCCGTCACACCTGCTCTGGCCACTAACATGGGGACCAGGTGGTGTTGGCTCCCGTATC	51.67%
Apta_819	DNA	GCGCCCTCTCACGTGGCACTCAGAGTGCCGGAAGTTCTGCGTTAT	51.11%
Apta_833	DNA	ATTTCGCCCCCGTGTTCCGACTGGTATCTTCACGTCTTCGAGTGT	51.11%
Apta_510	DNA	TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA	51.02%
Apta_1125	DNA	TCGGGCGAGTCGTCTGGGGAGGTCAGAACGAAAGGCCCGCATCGTCCTCCC	50.98%
Apta_1127	DNA	TCGGGCGAGTCGTCTGCGAGGCAACAAGCTCGTAATCCGCATCGTCCTCCC	50.98%
Apta_79	DNA	ATCTCGAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACTCGT	50.91%

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