AptaDB: Result

Interaction ID: 263

Aptamer sequence: CACTGCGGGGGTCTATACGTGAGGAAGAAGTGGGCAGGTC

Target unique ID: P08637

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_258	CLN0020	Protein	FCG3A_HUMAN	45 nM	DPBS with 0.05% BSA	21531729

Aptamer Sequence:	CACTGCGGGGGTCTATACGTGAGGAAGAAGTGGGCAGGTC
The optimal secondary structure in dot-bracket notation:	..((((.....(((...........))).....))))...
The centroid secondary structure in dot-bracket notation:	..((((.....(((...........))).....))))...

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_258	Description	CLN0020
Aptamer chemistry	DNA	Length	40 nt
GC content	60.0%	Molecular weight	12,746.96 Da
Molarity of 1 μg/μl solution	78.45 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	CACTGCGGGGGTCTATACGTGAGGAAGAAGTGGGCAGGTC
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P08637	Protein name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene name(s)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Organism	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Status	reviewed in uniprot database	Length	254
Mass	29,089	Activity regulation	N/A
Involvement in disease	Immunodeficiency 20 (IMD20)	Catalytic activity	N/A
PDB ID(s)	3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5VU0;5XJE;5XJF;5YC5;7SEG;
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).

	Interaction ID	263
	Target type	Protein
	Target unique ID	P08637
	Activity	45 nM
	Binding Conditions/Buffer	DPBS with 0.05% BSA
	Assay	Fitted CLN0020 binding to both CD16 allotypes and minor binding to CD16. Enlarged symbols represent calculated KD values
	PubMed ID	21531729

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_552	DNA	CACCTGGGGGAGTATTGCGGAGGAAGGTTCCAGGTG	67.50%
Apta_47	DNA	GACCTAGCAGTGGACATGTGGCAGGGTGAAGTGGCATCGTC	60.98%
Apta_75	DNA	CACTGGTAGGTTGGTGTGGTTGGGGCCAGTG	57.50%
Apta_829	DNA	CCCTCCGGGGGGGTCATCGGGATACCTGGTAAGGATA	57.50%
Apta_591	DNA	CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC	56.86%
Apta_1092	DNA	CCCATGGTAGGTATTGCTTGGTAGGGATAGTGGGCTTGATG	56.10%
Apta_943	DNA	GAAGGTGGAGCGGTTAGGATACTAGCGAATGAAGACACGTTAGCTGATCT	56.00%
Apta_46	DNA	CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT	55.00%
Apta_63	DNA	GACCCGTGGTAGGGTAGGATGGGGTGGTC	55.00%
Apta_318	DNA	CCCGTCTTCCAGACAAGAGTGCAGGG	55.00%
Apta_343	DNA	AACAGAGGGACAAACGGGGGAAGATTTGACGTCGACGAC	55.00%
Apta_579	DNA	ACTGAGGGCACGGACAGGAGGGGGAGAGATGGCGTGAGGT	55.00%
Apta_630	DNA	GACCAGGGCAAACGGTAGGGAGTGGTC	55.00%
Apta_1091	DNA	CCATGGTAGGTATTGCTTGGTAGGGATAGTGGGCTTGATG	55.00%
Apta_1190	DNA	TTCAGGGCGGGGTAAACGGGAGGTGGGGGGGGCTTGGGAC	55.00%
Apta_1203	DNA	CCCTGCGGGGCTACCCGATATGTGTCCGAGTGGTG	55.00%
Apta_654	DNA	GCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTG	53.70%
Apta_1012	DNA	CACATTAGGGCGGGGTACTCCTATCACGTATGGGGGCCTGT	53.66%
Apta_617	DNA	CAATGGGGTCGGGCGGGCCGGGTGTCATGGTGGACGGAGATGGGACGTAGAGGGCGGT	53.45%
Apta_585	DNA	GATCGAGGGCAGCGATAGCTGGGCTAATAAGGTTAGCCCCATCGGTC	53.19%

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