AptaDB: Result

Interaction ID: 393

Aptamer sequence: CTTTAATGCCCTTCACTAGGTCTAAGCTACTACTTACCCG

Target unique ID: P30990

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_387	B32	Protein	NEUT_HUMAN	5 nM	SHMCK buffer containing 0.1% (w/v) HSA, 0.2% (w/v) CHAPS, 0.04% (w/v) CHS, and 0.1% (w/v) LM	12054450

Aptamer Sequence:	CTTTAATGCCCTTCACTAGGTCTAAGCTACTACTTACCCG
The optimal secondary structure in dot-bracket notation:	.........(((.....)))..((((......))))....
The centroid secondary structure in dot-bracket notation:	.......................(((......))).....

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_387	Description	B32
Aptamer chemistry	DNA	Length	40 nt
GC content	45.0%	Molecular weight	12,116.80 Da
Molarity of 1 μg/μl solution	82.53 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	CTTTAATGCCCTTCACTAGGTCTAAGCTACTACTTACCCG
Applications	Binding to GPCRs

Type	Detail	Type	Detail
Uniprot ID	P30990	Protein name	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]
Gene name(s)	NTS	Organism	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]
Status	reviewed in uniprot database	Length	170
Mass	19,795	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	2LNE;2LNF;2LNG;2LYW;2OYV;2OYW;3F6K;4PO7;5LUZ;6UP7;
Function	Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism.

No relevant experimental diagram	Interaction ID	393
	Target type	Protein
	Target unique ID	P30990
	Activity	5 nM
	Binding Conditions/Buffer	SHMCK buffer containing 0.1% (w/v) HSA, 0.2% (w/v) CHAPS, 0.04% (w/v) CHS, and 0.1% (w/v) LM
	Assay	N/A
	PubMed ID	12054450

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_204	DNA	CCAAGGCTTTAGGTCTGAGATCTCCC	57.50%
Apta_205	DNA	TTAAGGCTTTAGGTCTGAGATCTCTT	57.50%
Apta_986	DNA	CGTGTATCCCCTGTGTGTTTGTACTCGGCTACTGTATCCG	57.50%
Apta_1215	DNA	GTCGAATCAGCACCTCTGCATAGGTTACGTTTATACTGCG	55.00%
Apta_421	DNA	ATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGCCCGTGA	53.06%
Apta_190	DNA	AGGAACCCTTTAGGTCTGAGATCTCGGAAT	52.50%
Apta_203	DNA	GGAAGGCTTTAGGTCTGAGATCTCGG	52.50%
Apta_306	DNA	CAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCG	52.50%
Apta_505	DNA	CTAAAGTGCCTCACGCTGTTAACTC	52.50%
Apta_877	DNA	GTGCGAAGCGCCTCCACTGTACATCCACTCCTTCTGCC	52.50%
Apta_961	DNA	CTAGTGGGGACCTTCCAGGGTAACTGCTCGCATTCTCCAT	52.50%
Apta_1192	DNA	CTTTCTGTCCTTCCGTCACATCCCACGCATTCTCCACAT	52.50%
Apta_238	DNA	CACACATTCCCGTCCTCGATACGTCTAGGCTTAGTGCCACTTGCTTAATC	52.00%
Apta_597	DNA	TACTGGGCTGGGCTTGGATTAGATCACAGTGGAACATACAGGACACACG	51.02%
Apta_1278	DNA	CCATGATTCAACTTTACTGGTCTTGTCTTGGCTAGTCGTGTGTCATTCCCTAAGG	50.91%
Apta_146	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG	50.00%
Apta_184	DNA	AGGAAGGCTTTAGGTCTGAGATCTCGGAAT	50.00%
Apta_185	DNA	ACCAAGGCTTTAGGTCTGAGATCTCCCAAT	50.00%
Apta_186	DNA	AGGAACGCTTTAGGTCTGAGATCTCGGAAT	50.00%
Apta_196	DNA	AGGAAGGCTTTAGGTCTGAGATCTC	50.00%

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