Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 329
Aptamer sequence: CAAGCUUGCGGGUUGGCUUGUAACAAGAUCGCUACGUGUUGAACUCUGCAACACUGGUCGGAUAGCGUAAACGGG
Target unique ID: 6140
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1055 527 Molecule Phenylalanine 0.49 mM 50 mM Hepes (pH 7.0), 0.3 M NaCl, 5 mM CaCl2, and 5 mM MgCl2 11847556
Structure information of aptamer
Aptamer Sequence: CAAGCUUGCGGGUUGGCUUGUAACAAGAUCGCUACGUGUUGAACUCUGCAACACUGGUCGGAUAGCGUAAACGGG
The optimal secondary structure in dot-bracket notation: ((((((........)))))).........(((((.((((((.......))))))))).))...............
The centroid secondary structure in dot-bracket notation: ((((((........))))))...........(((.((((((.......)))))))))..................
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1055 Description 527
Aptamer chemistry RNA Length 75 nt
GC content 52.0% Molecular weight 23,249.88 Da
Molarity of 1 μg/μl solution 43.01 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence CAAGCUUGCGGGUUGGCUUGUAACAAGAUCGCUACGUGUUGAACUCUGCAACACUGGUCGGAUAGCGUAAACGGG
Applications Determination of phenylalanine
Target information
Type Detail Type Detail
PubChem ID 6140 Molecular name Phenylalanine
Molecular formula C9H11NO2 Molecular weight 165.19
IUPAC name (2S)-2-amino-3-phenylpropanoic acid InChIKey COLNVLDHVKWLRT-QMMMGPOBSA-N
LogP 0.641 Topological polar surface area 63.32
Hydrogen bond acceptor 2 Hydrogen bond donor 2

Synonym(s):
L-phenylalanine; phenylalanine; 63-91-2; (S)-2-Amino-3-phenylpropanoic acid; 3-Phenyl-L-alanine; (2S)-2-amino-3-phenylpropanoic acid; (S)-Phenylalanine; (S)-2-Amino-3-phenylpropionic acid; beta-Phenyl-L-alanine; (L)-Phenylalanine; 3-Phenylalanine; H-Phe-OH; Antibiotic FN 1636; L-Alanine, phenyl-; Alanine, 3-phenyl-; L-Antibiotic FN 1636; (S)-alpha-Amino-beta-phenylpropionic acid; L-Alanine, 3-phenyl-; Phenylalanine (VAN); Fenilalanina [Spanish]; Phenylalaninum [Latin]; (S)-alpha-Aminohydrocinnamic acid; Alanine, phenyl-, L-; (S)-(-)-Phenylalanine; beta-Phenylalnine, (-)-; (S)-alpha-Amino-benzenepropanoic acid; FEMA No. 3585; Phenylalanine, L-; Hydrocinnamic acid, alpha-amino-; 2-Amino-3-phenylpropionic acid, L-; Phenylalanine [USAN:INN:JAN]; HSDB 1825; alpha-Aminohydrocinnamic acid, L-; alpha-Amino-beta-phenylpropionic acid, L-; Benzenepropanoic acid, alpha-amino-, (S)-; fenilalanina; alpha-Aminohydrocinnamic acid; endophenyl; NSC 79477; L-Phe; UNII-47E5O17Y3R; L-PHENYLALININE; MFCD00064227; 67675-33-6; CHEMBL301523; CHEBI:17295; L-2-Amino-3-phenylpropionic acid; phe; 47E5O17Y3R; Phenylalaninum; phenylalanin; Phenylalamine; Phenylalanine (L-Phenylalanine); Alanine, phenyl-; .beta.-Phenylalanine; Phenyl-.alpha.-alanine; L-.beta.-Phenylalanine; .beta.-Phenyl-L-alanine; (-)-.beta.-Phenylalanine; EINECS 200-568-1; .alpha.-Aminohydrocinnamic acid; .beta.-Phenyl-.alpha.-alanine; Phenylalanine (USP/INN); L-phenylaniline; Hydrocinnamic acid, .alpha.-amino-; NSC-9959; CCRIS 4254; .beta.-Phenyl-.alpha.-alanine, l-; NSC-79477; L-phenyl Alanine; PheOH; 1usi; NCI9959; (-)-phenylalanine; .alpha.-Amino-.beta.-phenylpropionic acid; racemic phenylalanine; Phenylalanine [USAN:USP:INN:JAN]; 1f2p; alpha-Aminohydrocinnamate; (-)-beta-Phenylalanine; L-Phenylalanine, 99%; beta-Phenyl-alpha-alanine; L-Phenylalanine (JP17); bmse000045; bmse000900; bmse000921; bmse001016; SCHEMBL8119; NCIStruc1_000204; NCIStruc2_000248; H-Phe-2-Chlorotrityl Resin; L-(-)-PHENYLALANINE; (S)-alpha-Aminohydrocinnamate; L-Phenylalanine (H-Phe-OH); L-2-Amino-3-phenylpropionate; L-Phenylalanine, 99%, FCC; GTPL3313; (S)-alpha-Aminobenzenepropanoate; 3-Amino-4-phenyl-butanoic acid; DTXSID4040763; (S)-2-amino-3-phenylpropanoate; BDBM18073; (S)-2-Amino-3-phenylpropionate; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; L-Phenylalanine non-animal source; (S)-alpha-Amino-benzenepropanoate; ZINC105196; HY-N0215; L-2-amino-3-phenyl-propionic acid; (S)-alpha-Aminobenzenepropanoic acid; AC8117; CCG-37572; NCGC00013103; L-[2,3,4,5,6-3H]phenylalanine; (S)-alpha-Amino-beta-phenylpropionate; AKOS010373257; AKOS015853585; L-Phenylalanine, Cell Culture Reagent; (S)-.alpha.-Aminobenzenepropanoic acid; DB00120; L-Phenylalanine, Vetec(TM), 98.5%; MCULE-5960921520; L-Phenylalanine, reagent grade, >=98%; NCGC00013103-02; NCGC00013103-03; NCGC00013103-04; NCGC00013103-05; NCGC00095047-01; NCGC00095047-02; NCGC00095047-03; NCGC00095047-04; AC-22417; AS-14129; BP-20538; K018; AB0013977; DB-029978; L-Phenylalanine, 99%, natural, FCC, FG; AM20060774; P0134; Benzenepropanoic acid, .alpha.-amino-, (S)-; L-Phenylalanine, BioUltra, >=99.0% (NT); 63P912; A20654; C00079; D00021; M02961; 34149-EP2289892A1; 34149-EP2301939A1; 34149-EP2305688A1; 34149-EP2305825A1; 34149-EP2311850A1; L-Phenylalanine, SAJ special grade, >=99.0%; 125851-EP2284178A2; 125851-EP2284179A2; 125851-EP2295422A2; Q170545; L-Phenylalanine, Vetec(TM) reagent grade, >=98%; Q-201326; F0001-2360; Z1258578341; L-Phenylalanine, certified reference material, TraceCERT(R); UNII-0O72R8RF8A component COLNVLDHVKWLRT-QMMMGPOBSA-N; UNII-8P946UF12S component COLNVLDHVKWLRT-QMMMGPOBSA-N; UNII-N7U7BXP2OI component COLNVLDHVKWLRT-QMMMGPOBSA-N; Phenylalanine, European Pharmacopoeia (EP) Reference Standard; 3-(2-AMINOETHYL)-1,3-THIAZOLIDINE-2,4-DIONEHYDROCHLORIDE; L-Phenylalanine, United States Pharmacopeia (USP) Reference Standard; L(-)-phenylalanine; Beta-phenylalanine;Dl-2-amino-3-phenylpropanoic acid;; L-Phenylalanine, analytical standard, for Nitrogen Determination According to Kjeldahl Method; L-Phenylalanine, Pharmaceutical Secondary Standard; Certified Reference Material; L-Phenylalanine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%; L-Phenylalanine, PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture

Activity data

No relevant experimental diagram

Interaction ID 329
Target type Molecule
Target unique ID 6140
Activity 0.49 mM
Binding Conditions/Buffer

50 mM Hepes (pH 7.0), 0.3 M NaCl, 5 mM CaCl2, and 5 mM MgCl2

Assay

N/A

PubMed ID 11847556
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_410 RNA GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGG 52.94%
Apta_566 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCCUGCGAUGCAGAAAGGUGCUGACGACACAUCGAAACGGUAGCGAGAGCUC 51.11%
Apta_80 RNA GCAAUGGUACGGUACUUCCUUUGGAAGAUAGCUGGAGAACUAACCAAAAGUGCACGCUACUUUGCUAA 50.67%
Apta_269 RNA AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC 50.67%
Apta_1168 RNA GCGACUACGGUGAGGGUCGGGUCCAGUAGCUUCGGCUACUGUUGAGUAGAGUGUGGGCUCCGUAGUCGC 50.67%
Apta_432 RNA GGGAGACAAGAAUAAACGCUCAAGGCAUUUCUGCUAGUCUGGUUGUAAGAUAUUCAACACGUGAGUUUCGACAGGAGGCUCACAACAGGC 50.00%
Apta_561 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUGUGGAAACAGACGUGGCACAUGACUACGUCGAAACGGUAGCGAGAGCUC 50.00%
Apta_720 RNA GGGAGAAUUCCGACCAGAAGCUUAGUAUAGCGAGGUUUAGCUACACUCGUGCUGAUCGUUUGGUACGGGACCUGCGUGUAGCCCAUAUGUGCGUCUACAUGGAUCCUCA 49.54%
Apta_353 RNA GAAUUCCGCGUGUGCCAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCGGUCCGUUCGGGAUCC 49.37%
Apta_2 RNA GGGCUUCUCUGGUUAGACCAGAUUUGAGCCUGGGAGCUCUCUGGCUAACUAGGGAACCC 49.33%
Apta_575 RNA AGAGCUUGACGGUCCCGAGAGUCGAGCCCAAGCUGACACUGGACCUUUGCGGACCACGUGUUGAUCGUCG 49.33%
Apta_1143 RNA ACGAGUUGUCGCAUGUGCGGUUCAGUCUGGUCCUUCAGCACCGUACAACAA 49.33%
Apta_1224 RNA GGAGGCGCCAACUGAAUGAAUGUUCUGGAUCUGCUAGAGACUAUCUGCUUCGGCAGCACUCUCCGUUAACAACACGUACAUCCGUAACUAGUCGCGUCAC 49.00%
Apta_710 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGUCUGGAUACCAUGCAUGAUGCACCUUGGCAGUCUUACGAAACGGUAGCGAGAGCUC 48.94%
Apta_380 RNA GGGAUGCUUCGGCAUCCCCGAAGCCGCUAUGGACCAGUGGCGCGGCUUCGGCCCGACGGAGUGGUACCGCUUCGGCGGUACGUAAGCUUGGG 48.91%
Apta_396 RNA GGGAGGACGAUGCGGCAGUCUGCAUCGUAGGAAUCGCCACCGUAUACUUUCCCACCAGACGACUCGCUGAGGAUCCGAGA 48.75%
Apta_559 RNA GGAUGUCCAGUCGCUUGCAAUGCCCUUUUAGACCCUGAUGAGGAUCAUCGGACUUUGUCCUGUGGAGUAAGAUCGCGAAACGGUGAAAGCCGUAGGUCU 48.48%
Apta_276 RNA GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC 48.24%
Apta_429 RNA GCAUGCAGUGUCUAUUCUCGAGUAGCGAUCGUUGAAGGGGUAUAAGGUUGGCAGAUCGCUAGCAUGCAACUGACUCGGAUAAGCA 48.24%
Apta_428 RNA GAAGCUUACAAGAAGGACAGCACGAAUAAAACCUGCGUAAAUCCGCCCCAUUUGUGUAAGGGUAGUGGGUCGAAUUCCGCUCA 48.19%