AptaDB: Result

Interaction ID: 3

Aptamer sequence: CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC

Target unique ID: E0Z2R8

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_3	Aptamer A14	Protein	E0Z2R8_9INFA	2.98 nM	40nM HEPES (pH 7.5); 102mM NaCl; 5mM KCl; 5mM MgCl2, 0.05% Tween-20	31196363

Aptamer Sequence:	CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC
The optimal secondary structure in dot-bracket notation:	.(((((...))))).((((.........))))...........
The centroid secondary structure in dot-bracket notation:	...(((.................))).................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_3	Description	Aptamer A14
Aptamer chemistry	DNA	Length	43 nt
GC content	69.8%	Molecular weight	13,169.44 Da
Molarity of 1 μg/μl solution	75.93 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Target recognition
Sequence	CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC
Applications	Binds specifically to H3N2 subtype of influenza virus

Type	Detail	Type	Detail
Uniprot ID	E0Z2R8	Protein name	Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
Gene name(s)	HA	Organism	Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
Status	unreviewed in uniprot database	Length	566
Mass	63,236	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	N/A
Function	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.

No relevant experimental diagram	Interaction ID	3
	Target type	Protein
	Target unique ID	E0Z2R8
	Activity	2.98 nM
	Binding Conditions/Buffer	40nM HEPES (pH 7.5); 102mM NaCl; 5mM KCl; 5mM MgCl2, 0.05% Tween-20
	Assay	N/A
	PubMed ID	31196363

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_4	DNA	CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC	69.57%
Apta_1018	DNA	ATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGG	60.87%
Apta_469	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACACCCCAG	55.81%
Apta_966	DNA	GGCCTGGTCTGTTAGCCGGGTAGCAGCCCCGGCACCTATT	55.81%
Apta_968	DNA	TAACACGACAGACGTTCGGAGGTCGAACCCTGACAGCGTGGGC	55.81%
Apta_153	RNA	CCACAGUUCAGAGGCACCGCGAACAAAACGCAAGACAGAGUGCCGACAAGAAC	54.72%
Apta_269	RNA	AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC	53.85%
Apta_145	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGA	53.49%
Apta_468	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACACCCCAT	53.49%
Apta_470	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACACCTCAT	53.49%
Apta_471	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACGCCCCAG	53.49%
Apta_717	RNA	GGCGCAGCCCGCCGAAAGGCACGUGGAACCGUC	53.49%
Apta_1126	DNA	TCGGGCGAGTCGTCTGCGGGCGGATAGACTACGACACCGCATCGTCCTCCC	52.94%
Apta_856	RNA	UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA	52.08%
Apta_1070	DNA	CCGTATCGCCCAGGCAACTGGGCTAAACTTCCCAGAGGGAACGAAACCTGGG	51.92%
Apta_1082	DNA	GGCTGGTCCGCTGGGAACAAGGGCGGGAGGGAGGGTGTGGGTGCGACAAGCGGACCAGCC	51.67%
Apta_56	DNA	GCAGCTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC	51.16%
Apta_503	DNA	ACTTTTGAATGTGGCAACAAATTCGACAGG	51.16%
Apta_1060	DNA	AGCAATATTGCCCGCGCGGGGCCAACTGTCCTCACATGA	51.16%
Apta_485	DNA	TGTCGTTGGGGGGGTAGGGAAGGGTGAAACGACAAGCCAGAAGTT	51.11%

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