AptaDB: Result

Interaction ID: 269

Aptamer sequence: GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT

Target unique ID: P08637

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_264	CLN0126	Protein	FCG3A_HUMAN	46 nM	DPBS with 0.05% BSA	21531729

Aptamer Sequence:	GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT
The optimal secondary structure in dot-bracket notation:	.(((((....)))))((((....)))).............
The centroid secondary structure in dot-bracket notation:	.(((((....)))))((((....)))).............

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_264	Description	CLN0126
Aptamer chemistry	DNA	Length	40 nt
GC content	70.0%	Molecular weight	12,783.92 Da
Molarity of 1 μg/μl solution	78.22 μM	Number of G-quadruplexes	2
G-Score	19	Function	Targeted binding
Sequence	GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P08637	Protein name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene name(s)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Organism	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Status	reviewed in uniprot database	Length	254
Mass	29,089	Activity regulation	N/A
Involvement in disease	Immunodeficiency 20 (IMD20)	Catalytic activity	N/A
PDB ID(s)	3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5VU0;5XJE;5XJF;5YC5;7SEG;
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).

No relevant experimental diagram	Interaction ID	269
	Target type	Protein
	Target unique ID	P08637
	Activity	46 nM
	Binding Conditions/Buffer	DPBS with 0.05% BSA
	Assay	N/A
	PubMed ID	21531729

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_259	DNA	GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT	67.50%
Apta_260	DNA	GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT	67.50%
Apta_144	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG	61.36%
Apta_145	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGA	60.00%
Apta_830	DNA	GACGGTGGCAGGGAAAGGGGTCGGGCATATGGCGGAGGGG	60.00%
Apta_1237	DNA	GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG	60.00%
Apta_1186	DNA	AGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT	59.09%
Apta_748	DNA	AGCTTGAGGGTGGGCGGGTGGACGCGGTAGTGGTATATAGGTCGG	57.78%
Apta_1185	DNA	CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT	57.78%
Apta_146	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG	57.50%
Apta_150	DNA	CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG	57.50%
Apta_350	DNA	GGTGGTGGTGGTTGTGGTGGTGGTGG	57.50%
Apta_675	DNA	ACTGTCCGTCGGGTTTAGGGTGGCGTTCGG	57.50%
Apta_682	DNA	CCTTGTAGATCGGGTGTGGTTTGGCGTAGG	57.50%
Apta_693	DNA	CGAGTTGAGCCGGGCGCGGTACGGGTACTGGTATGTGTGG	57.50%
Apta_1195	DNA	GGGGTTGGGGGGAGGCGGGGAATGGGGG	57.50%
Apta_1240	DNA	GGAGTAGTGGGGATTGTGGTGTATGTTGTC	57.50%
Apta_217	DNA	CGCCTGATTAGCGATACTCAGGCGTTGGGTGGGTGGGTGGG	56.10%
Apta_1062	DNA	GGGGTCTTGCAGGTCCCGTAGGAGGGGCCATTGGAGTGGGG	56.10%
Apta_596	DNA	GGTGGCTGTTGGTCGAGGCTTATTAGTGTAGTCAATGGAGGCAGGCGACG	56.00%

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