AptaDB: Result

Interaction ID: 4

Aptamer sequence: CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC

Target unique ID: E0Z2R8

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_4	Aptamer A1	Protein	E0Z2R8_9INFA	3.36 nM	40nM HEPES (pH 7.5); 102mM NaCl; 5mM KCl; 5mM MgCl2, 0.05% Tween-20	31196363

Aptamer Sequence:	CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC
The optimal secondary structure in dot-bracket notation:	..(((((((.....((.((....)).))...)))))))........
The centroid secondary structure in dot-bracket notation:	..(((((((.....((.((....)).))...)))))))........

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_4	Description	Aptamer A1
Aptamer chemistry	DNA	Length	46 nt
GC content	67.4%	Molecular weight	14,125.06 Da
Molarity of 1 μg/μl solution	70.80 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Target recognition
Sequence	CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC
Applications	Binds specifically to H3N2 subtype of influenza virus

Type	Detail	Type	Detail
Uniprot ID	E0Z2R8	Protein name	Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
Gene name(s)	HA	Organism	Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
Status	unreviewed in uniprot database	Length	566
Mass	63,236	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	N/A
Function	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.

No relevant experimental diagram	Interaction ID	4
	Target type	Protein
	Target unique ID	E0Z2R8
	Activity	3.36 nM
	Binding Conditions/Buffer	40nM HEPES (pH 7.5); 102mM NaCl; 5mM KCl; 5mM MgCl2, 0.05% Tween-20
	Assay	N/A
	PubMed ID	31196363

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_3	DNA	CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC	69.57%
Apta_621	DNA	AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC	54.55%
Apta_469	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACACCCCAG	54.35%
Apta_471	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACGCCCCAG	54.35%
Apta_663	DNA	CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG	53.33%
Apta_1082	DNA	GGCTGGTCCGCTGGGAACAAGGGCGGGAGGGAGGGTGTGGGTGCGACAAGCGGACCAGCC	53.33%
Apta_153	RNA	CCACAGUUCAGAGGCACCGCGAACAAAACGCAAGACAGAGUGCCGACAAGAAC	52.83%
Apta_558	DNA	CCGGTGGGTGGTCAGGTGGGATAGCGTTCCGCGTATGGCCCAGCGCATCACGGGTTCGCACCA	52.38%
Apta_385	DNA	ACAGATACGGAACTACAGAGGTCAATTACGGTGGCCACGC	52.17%
Apta_468	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACACCCCAT	52.17%
Apta_470	DNA	CTGTAATTGGCGTATGTAACCCAGGCACCAAACACCTCAT	52.17%
Apta_579	DNA	ACTGAGGGCACGGACAGGAGGGGGAGAGATGGCGTGAGGT	52.17%
Apta_939	DNA	TTGCCCACCGTACTGTGCAGGTCGAACTACAGGCACGTCGTG	52.17%
Apta_1018	DNA	ATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGG	52.17%
Apta_1046	DNA	TCGCATGGAGGGCAGAGCCGCCTGCCGGGATCCGGCCCTCTTGGGCGGGC	52.00%
Apta_1068	DNA	CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG	51.92%
Apta_1069	DNA	CCGGAGAAAAAAAACTTGATGAGCCAGGAAAACGAGGGTTGGAACGCGACTG	51.92%
Apta_447	RNA	ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC	50.88%
Apta_160	DNA	CGGTGCAGTGGATACATGCCAGCCGTAGCCATCGTGGATA	50.00%
Apta_163	DNA	GCGCATGACCATTGATGTCTGCACCATCAGAGGCAGAG	50.00%

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