Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1110
Aptamer sequence: ATGCGGATCCCGCGCGGGTCTGAGGAGTGCGCGGTGCCAGTGAGTGCGCGAAGCTTGCGC
Target unique ID: Other-51
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1035 HBA2 Other Avian Influenza Virus Subtype H5N1 122.4 nM Tris buffer (20 mM, pH 7.4) 32731467
Structure information of aptamer
Aptamer Sequence: ATGCGGATCCCGCGCGGGTCTGAGGAGTGCGCGGTGCCAGTGAGTGCGCGAAGCTTGCGC
The optimal secondary structure in dot-bracket notation: ..((((...))))(((((.((.....((((((...........))))))..)))))))..
The centroid secondary structure in dot-bracket notation: ....((.....(((((...........)))))....)).......(((((.....)))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1035 Description HBA2
Aptamer chemistry DNA Length 60 nt
GC content 70.0% Molecular weight 18,671.89 Da
Molarity of 1 μg/μl solution 53.56 μM Number of G-quadruplexes 2
G-Score 19 Function Targeted therapy
Sequence ATGCGGATCCCGCGCGGGTCTGAGGAGTGCGCGGTGCCAGTGAGTGCGCGAAGCTTGCGC
Applications Inhibited hemagglutination, which is caused by the virus surface protein hemagglutinin
Target information
Type Detail Type Detail
Target ID Other-51 Name Avian Influenza Virus Subtype H5N1
Activity data
Interaction ID 1110
Target type Other
Target unique ID Other-51
Activity 122.4 nM
Binding Conditions/Buffer

Tris buffer (20 mM, pH 7.4)
Assay

N/A
PubMed ID 32731467
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1034 DNA ATGCGGATCCCGCGCGCGACCGTGTCAGCGGGGACTAGCGGTGTAGCGCGAAGCTTGCGC 73.33%
Apta_1006 DNA ATAGGAGTCGACCGACCAGAACTTGTCTTAGGAGGTTTACGGTGGGAATAGTGCGTCTACATCTAGACTC 60.00%
Apta_143 DNA GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAGTTTCG 56.67%
Apta_255 DNA TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT 56.67%
Apta_666 DNA TCGACCTCGCGCGAGGAGGGTGGAGGGTCGTAGAGCGCGTA 56.67%
Apta_831 DNA CCGCCCAGCGGGGGTAGGGCCGGACGTAGGAGGAGCTGCG 56.67%
Apta_708 DNA CGTACGGAATTCGCTAGCGGGCGGGGGTGCTGGGGGAATGGAGTGCTGCGTGCTGCGGGGATCCGAGCTCCACGTG 55.26%
Apta_565 DNA GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG 55.00%
Apta_617 DNA CAATGGGGTCGGGCGGGCCGGGTGTCATGGTGGACGGAGATGGGACGTAGAGGGCGGT 55.00%
Apta_750 DNA ATGCGAACAGGTGGGTGGGTTGGGTGGATTGTTCGGCTTCTTGAT 55.00%
Apta_834 DNA CGCAATACCAAAGTGGCGAGAGCGCTGTCTTGAGTGAGTGGTTGG 55.00%
Apta_979 DNA ATGAGTAGTGCGGAGGGATGTGAATACTGACGCGGTCATAGTCGCTGTTGTACCATTGA 55.00%
Apta_1041 DNA TTGGCCCCGCGTGATCATTGAGGGGAGGAGCCGAGGCGGGTCCAAGATTG 55.00%
Apta_1189 DNA GCGGGCGGGGGGAGGGCGGCCGTGGGCTGCGAGTGGGAGG 55.00%
Apta_508 DNA GCGGGCGATCGGCGGGGGGTGCGTGCGCTCTGTGCCAGGGGGTGGGACAGATCATATGGGGGTGCT 54.55%
Apta_1115 DNA CGTACGGAATTCGCTAGCGGTGACGGACGTGGGGTGCACGAAGGGAGGGGATCCGAGCTCCACGTG 54.55%
Apta_1017 DNA TAGGGAATTCGTCGACGGATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGGTCGACGCATGCGCCG 54.43%
Apta_336 DNA CATGCTTCCCCAGGGAGATGACCGGGGCGTACACCGTCGCGGCACATGTCTGAATGCGTTTAGTCTCTGTGG 54.17%
Apta_1120 DNA GGGAATGGATCCACATCTACGAATTCGGAATGAGTGCCCTGCAAGCGAGGGCTAGCTTCACTGCAGACTTGACGAAGCTT 53.75%
Apta_1004 DNA ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCACTGTGACACAATGGTGCGTCTACATCTAGACTC 53.62%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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