AptaDB: Result

Interaction ID: 1041

Aptamer sequence: CGCGTGAGCGGGGAGGCGATGCCCAGGCTAACTTGACTCA

Target unique ID: P01266

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_958	T-2	Protein	THYG_HUMAN	3.18 μM	TGK, Tris-HCl, BBS, and PBS	33303143

Aptamer Sequence:	CGCGTGAGCGGGGAGGCGATGCCCAGGCTAACTTGACTCA
The optimal secondary structure in dot-bracket notation:	....((((((((..(((.........)))..)))).))))
The centroid secondary structure in dot-bracket notation:	....((((((((..(((.........)))..)))).))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_958	Description	T-2
Aptamer chemistry	DNA	Length	40 nt
GC content	65.0%	Molecular weight	12,387.94 Da
Molarity of 1 μg/μl solution	80.72 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	CGCGTGAGCGGGGAGGCGATGCCCAGGCTAACTTGACTCA
Applications	CE-based detection validated the application feasibility of aptamer for Tg detection

Type	Detail	Type	Detail
Uniprot ID	P01266	Protein name	Thyroglobulin (Tg)
Gene name(s)	TG	Organism	Thyroglobulin (Tg)
Status	reviewed in uniprot database	Length	2768
Mass	304,790	Activity regulation	N/A
Involvement in disease	Thyroid dyshormonogenesis 3 (TDH3)	Catalytic activity	N/A
PDB ID(s)	6SCJ;7B75;
Function	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

No relevant experimental diagram	Interaction ID	1041
	Target type	Protein
	Target unique ID	P01266
	Activity	3.18 μM
	Binding Conditions/Buffer	TGK, Tris-HCl, BBS, and PBS
	Assay	N/A
	PubMed ID	33303143

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_124	DNA	GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC	55.00%
Apta_965	DNA	CACGGCATGTGTGGCCGGATGCCTATATCGGTCGACTGCA	55.00%
Apta_1261	DNA	GGGCGGACGCTAGGTGGTGATGCTGTGCTACACGTGTTGT	55.00%
Apta_310	DNA	GCGCCAGCTTTGCTGATGGGTGGCCACCCTTGCCCTGGGTTTGAATTTCGATCCTATCG	54.24%
Apta_558	DNA	CCGGTGGGTGGTCAGGTGGGATAGCGTTCCGCGTATGGCCCAGCGCATCACGGGTTCGCACCA	53.97%
Apta_1213	DNA	GGACTTGAAGAAAAGGGCGACACGCGAAGTCGATGTCGCGTCTGCCTGAAGTCA	53.70%
Apta_487	DNA	CGGGGAGTTGGGAGGGGGGGCAAAGCCTGTGTATTTATCTTCTGT	53.33%
Apta_748	DNA	AGCTTGAGGGTGGGCGGGTGGACGCGGTAGTGGTATATAGGTCGG	53.33%
Apta_287	DNA	CAGCACCGACCTTGTGCTTTGGGAGTGCTGGTCCAAGGGCGTTAATGGACA	52.94%
Apta_1125	DNA	TCGGGCGAGTCGTCTGGGGAGGTCAGAACGAAAGGCCCGCATCGTCCTCCC	52.94%
Apta_910	DNA	TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA	52.73%
Apta_19	DNA	TGAGGGGGGGGGAGGTCGGGCCTGC	52.50%
Apta_29	DNA	AGAGGGGGGGGACGGCCCGGGTAGA	52.50%
Apta_150	DNA	CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG	52.50%
Apta_160	DNA	CGGTGCAGTGGATACATGCCAGCCGTAGCCATCGTGGATA	52.50%
Apta_329	DNA	GGCGTACGGTAGGCGGGGTCAACTG	52.50%
Apta_362	DNA	GGGAACGCACCGATCGCAGGTTTCCC	52.50%
Apta_817	DNA	TGCGTGAGCGGTAGGCCCCTACGACCCACTGTGGTTGGGC	52.50%
Apta_1167	RNA	GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC	52.50%
Apta_1240	DNA	GGAGTAGTGGGGATTGTGGTGTATGTTGTC	52.50%

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