Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 750
Aptamer sequence: CCACACAACAGCCTACGTGGATACACCACATACATCCCATAACCCCGTGTCATGTGTCG
Target unique ID: 446512
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_689 OA 22 Molecule Okadaic acid 183 nM 50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM MgCl2 24164310
Structure information of aptamer
Aptamer Sequence: CCACACAACAGCCTACGTGGATACACCACATACATCCCATAACCCCGTGTCATGTGTCG
The optimal secondary structure in dot-bracket notation: ................((((.....))))((((((..(((......)))..))))))..
The centroid secondary structure in dot-bracket notation: ...........................................................
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_689 Description OA 22
Aptamer chemistry DNA Length 59 nt
GC content 52.5% Molecular weight 17,933.53 Da
Molarity of 1 μg/μl solution 55.76 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence CCACACAACAGCCTACGTGGATACACCACATACATCCCATAACCCCGTGTCATGTGTCG
Applications Detection of okadaic acid (OA)
Target information
Type Detail Type Detail
PubChem ID 446512 Molecular name Okadaic acid
Molecular formula C44H68O13 Molecular weight 805
IUPAC name (2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5-oxolane]-2-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoic acid InChIKey QNDVLZJODHBUFM-WFXQOWMNSA-N
LogP 5.214 Topological polar surface area 182.83
Hydrogen bond acceptor 12 Hydrogen bond donor 5

Synonym(s):
okadaic acid; 78111-17-8; C44H68O13; 9,10-Deepithio-9,10-didehydroacanthifolicin; CHEMBL280487; CHEBI:44658; MFCD00083455; UNII-1W21G5Q4N2; (2R)-3-[(2S,5R,6R,8S)-8-[(2R,3E)-4-[(2R,4'aR,5R,6'S,8'R,8'aS)-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-7'-methylidene-hexahydro-3'H-spiro[oxolane-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl]-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid; OKA; 1W21G5Q4N2; Okadaic acid (+Na); Okadaic acid from Prorocentrum concavum; 1jk7; Probes1_000180; SCHEMBL131485; CHEMBL158524; GTPL5349; DTXSID60880002; 1u32; HY-N6785; BDBM50097634; BDBM50110676; ZINC85601542; DB02169; CS-0014219; Q414042; Okadaic acid from Prorocentrum concavum, 92-100% (HPLC); Okadaic acid from Prorocentrum concavum, >=90% (HPLC), translucent film; (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(1R,2E)-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]-1-methylprop-2-en-1-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid

Activity data

No relevant experimental diagram

 Interaction ID 750
Target type Molecule
Target unique ID 446512
Activity 183 nM
Binding Conditions/Buffer

50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM MgCl2
Assay

N/A
PubMed ID 24164310
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1232 DNA GGCCACACAAACAACATGACAACACGTCTCACATAACGCCCACGTGCTGCCGCCTCATCG 56.67%
Apta_514 DNA ACTCAGCACGCGTGTAGGGAAAACCAACCGCCCACAAGCTGCATGCAACG 55.93%
Apta_728 DNA CGACCCGGCACAAACCCAGAACCATATACACGATCATTAGTCTCCTGGGCCG 55.93%
Apta_1268 DNA CACACACGCAGCAAGGTCGTCGATACAAAACGTATCGACCCGTCACAGACTGCCCCGGGT 55.00%
Apta_526 DNA ATACGGGAGCCAACACCAAGTAACACACGCGGACCAGAAATACATCCCCCCGTAGAGCAGGTGTGACGGAT 54.93%
Apta_730 DNA ACCAAACACAGATGCAACCTGACTTCTAACGTCATTTGGTG 54.24%
Apta_847 DNA CACTAGGATCTAGGGAAAAATCTCGTAAATACTATACTCCTGAGC 54.24%
Apta_1263 DNA CCCCGCTGCCCGTGTTCCGTCCTCCCTTGCTGTGTGTGCG 54.24%
Apta_523 DNA ATCCGTCACACCTGCTCTGACGCTGGGGTCGACCCGGAGAAATGCATTCCCCTGTGGTGTTGGCTCCCGTAT 54.17%
Apta_867 DNA CTCCTCTGACTGTAACCACGCCACCGAGCCTACCACATGTGACATCCCAGGACATAGCTGGCATAGGTAGTCCAGAAGCC 53.75%
Apta_688 DNA GCCATGACAACCAGAGGTACCCCCGCCCACCAGCCCCGAAGTCTGTCAGCCTAGTTGTTG 53.33%
Apta_1113 DNA CCGCCCAAATCCCTAAGAGCACAAACACCAAACACAACCACCCCAACCAGACACACTACACACGCA 53.03%
Apta_534 DNA ATCCGTCACACCTGCTCTTGTAGGGTTCCCACCCAATTCAGTTCCGTTAAACCATGGTGTTGGCTCCCGTAT 52.78%
Apta_534 DNA ATCCGTCACACCTGCTCTTGTAGGGTTCCCACCCAATTCAGTTCCGTTAAACCATGGTGTTGGCTCCCGTAT 52.78%
Apta_1048 DNA ATACGGGAGCCAACACCACCTGCGGAAAATCAACAACGACACACGCCACGATTCAGAGCAGGTGTGACGGAT 52.78%
Apta_1050 DNA ATCCGTCACACCTGCTCTCACGTCCGTCAACCAGATTGATACTTTATCTTGTTGTGGTGTTGGCTCCCGTAT 52.78%
Apta_56 DNA GCAGCTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC 52.54%
Apta_339 DNA CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTGT 52.54%
Apta_721 DNA CTCTCGGGACGACCGCGGTAGTCTTAACCTAAAGCGGTGTCAGGTCGTCCC 52.54%
Apta_871 DNA CCAACCACACATCCTTCCATCGACATGGACCCACCGTTCC 52.54%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

HELP CENTER

>Contact us
>LMMD Group
>School of Pharmacy

DEV TOOL
Page last updated at 2022-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 43963
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.