Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1037
Aptamer sequence: ATACGGGAGCCAACACCAGGACTAACATTATAAGAATTGCGAATAATCATTGGAGAGCAGGTGTGACGGAT
Target unique ID: P45379
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_954 91 Protein TNNT2_HUMAN N/A N/A 30979922
Structure information of aptamer
Aptamer Sequence: ATACGGGAGCCAACACCAGGACTAACATTATAAGAATTGCGAATAATCATTGGAGAGCAGGTGTGACGGAT
The optimal secondary structure in dot-bracket notation: .........((.(((((....((((.(((((...........)))))..))))......)))))...))..
The centroid secondary structure in dot-bracket notation: .........((.(((((..........................................)))))...))..
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_954 Description 91
Aptamer chemistry DNA Length 71 nt
GC content 43.7% Molecular weight 22,065.21 Da
Molarity of 1 μg/μl solution 45.32 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Target recognition
Sequence ATACGGGAGCCAACACCAGGACTAACATTATAAGAATTGCGAATAATCATTGGAGAGCAGGTGTGACGGAT
Applications Binding to target proteins
Target information
Type Detail Type Detail
Uniprot ID P45379 Protein name Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
Gene name(s) TNNT2 Organism Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
Status reviewed in uniprot database Length 298
Mass 35,924 Activity regulation N/A
Involvement in disease Cardiomyopathy, familial hypertrophic 2 (CMH2) Catalytic activity N/A
PDB ID(s)
1J1D;1J1E;4Y99;6KN7;6KN8;
Function Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Activity data

No relevant experimental diagram

 Interaction ID 1037
Target type Protein
Target unique ID P45379
Activity N/A
Binding Conditions/Buffer

N/A
Assay

N/A
PubMed ID 30979922
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_904 DNA ATACGGGAGCCAACACCAGACGGTAAATAAAGTCAGTATCGAGTACTCTATTCGAGAGCAGGTGTGACGGAT 79.17%
Apta_903 DNA ATACGGGAGCCAACACCAGACGGTAAATAAAGTCAGTATCGATACTCTATTCGAGAGCAGGTGTGACGGAT 78.87%
Apta_902 DNA ATACGGGAGCCAACACCACCAACATTATCAGAGTATGTTACTTATAGTGGTGGCAGAGCAGGTGTGACGGAT 77.78%
Apta_533 DNA ATACGGGAGCCAACACCAAAGTAAGATCATCACCCGGACGCGGACATAATAGGAGAGCAGGTGTGACGGAT 76.06%
Apta_533 DNA ATACGGGAGCCAACACCAAAGTAAGATCATCACCCGGACGCGGACATAATAGGAGAGCAGGTGTGACGGAT 76.06%
Apta_1049 DNA ATACGGGAGCCAACACCATGTACATTGTAGATTTATTTGCCCAAAACCCAAGAAGAGCAGGTGTGACGGAT 74.65%
Apta_527 DNA ATACGGGAGCCAACACCAACAACCTAGATGTTCTGATAACACGAATCGCTTCGAAGAGCAGGTGTGACGGAT 73.61%
Apta_531 DNA ATACGGGAGCCAACACCACATCGACTTACGAATCAACGCGTTTATTATTGGTTCAGAGCAGGTGTGACGGAT 73.61%
Apta_896 DNA ATACGGGAGCCAACACCATAAGTCTAAAAAACTGGGAGTAAACACAATGTGTATAGAGCAGGTGTGACGGAT 72.22%
Apta_901 DNA ATACGGGAGCCAACACCACAAGTTGACTTGGAGGAGGGTCTAACTAGTTCGAGGAGAGCAGGTGTGACGGAT 72.22%
Apta_907 DNA ATACGGGAGCCAACACCACAACAAGATAAAGTATCAATCTGGTTGACGGACGTGAGAGCAGGTGTGACGGAT 72.22%
Apta_824 DNA ATACGGGAGCCAACACCATCCCTCTTAGGATACAAAGCCAAACTGAGCCCGTGCAGAGCAGGTGTGACGGAT 70.83%
Apta_898 DNA ATACGGGAGCCAACACCAACAAAACTAGCAAATTAGAGCCGTATCGGAGCCTATAGAGCAGGTGTGACGGAT 70.83%
Apta_526 DNA ATACGGGAGCCAACACCAAGTAACACACGCGGACCAGAAATACATCCCCCCGTAGAGCAGGTGTGACGGAT 70.42%
Apta_528 DNA ATACGGGAGCCAACACCACTTGGTTAACCAATCAAACCGGACAACGAAGGGTCCAGAGCAGGTGTGACGGAT 69.44%
Apta_908 DNA ATACGGGAGCCAACACCAATTCCGCCAAAGTCTGCTAATAAACGGACGCCGGGGAGAGCAGGTGTGACGGAT 69.44%
Apta_897 DNA ATACGGGAGCCAACACCACTCTTATTTCCGGAAGTGGTTCTTCAACAGAGGAATAGAGCAGGTGTGACGGAT 68.06%
Apta_1048 DNA ATACGGGAGCCAACACCACCTGCGGAAAATCAACAACGACACACGCCACGATTCAGAGCAGGTGTGACGGAT 68.06%
Apta_825 DNA ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCCAGGGACCCCGTCTCTGAGAGCAGGTGTGACGGAT 66.67%
Apta_827 DNA ATACGGGAGCCAACACCACCCGTGGCCTTCACCCAGCCAGGGGCCCCGTCTCTGAGAGCAGGTGTGACGGAT 66.67%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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