Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 880
Aptamer sequence: GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG
Target unique ID: CRL-2945
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_796 mApoc46 Cell Primary serous ovarian cancer (pSOC) cells 0.15 μM PBS 33787226
Structure information of aptamer
Aptamer Sequence: GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG
The optimal secondary structure in dot-bracket notation: ...((((((((........................................))))))))
The centroid secondary structure in dot-bracket notation: ...((((((((........................................))))))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_796 Description mApoc46
Aptamer chemistry DNA Length 59 nt
GC content 57.6% Molecular weight 17,825.40 Da
Molarity of 1 μg/μl solution 56.10 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted therapy
Sequence GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG
Applications Molecular tools for rapid intraoperative diagnosis and In vivo imaging of serous ovarian cancer
Target information
Type Detail Type Detail
ATCC ID CRL-2945 Cell name Primary serous ovarian cancer (pSOC) cells
Category Human cells Organism Homo sapiens, human
Product type N/A Cell type N/A
Morphology epithelial-like Tissue Ovary
Disease Carcinoma Product format Frozen
Antigen expression Cytokeratin 7 (CK-7), positive; calretinin, positive Genes expressed p53; cytokeratin 7 (CK-7) positive; calretinin positive; Wilms' tumor protein (WT) positive; BRCA1 negative
Cell description N/A
Application(s) 3D cell culture; Cancer research
Activity data
Interaction ID 880
Target type Cell
Target unique ID CRL-2945
Activity 0.15 μM
Binding Conditions/Buffer

PBS
Assay

Binding curves of mApoc46 and mApoc14 to primary SOC cells
PubMed ID 33787226
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_797 DNA GTTCGTGGTGTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAGCAGCACGA 77.63%
Apta_799 DNA GTTCGTGGTGTGCTGGATGTCCCGTGCACGGCGCCACGTTTTCCTCTCATCCCCGATGACACATCCAGCAGCACGA 59.21%
Apta_1111 DNA GTGCGTCGCATGATCGCGATTAGTGCGACCATGTACGATTCTCACGACAACGACACTGTACTTGAGGACTGTCTCC 55.26%
Apta_489 DNA GGGGTTAAATATTCCCACATTGCCTGCGCCAGTACAAATAG 54.24%
Apta_877 DNA GTGCGAAGCGCCTCCACTGTACATCCACTCCTTCTGCC 54.24%
Apta_866 DNA CTCCTCTGACTGTAACCACGACCGCCTTCCACCGTTCTCCACCACCCCTCAAACAACCCTGCATAGGTAGTCCAGAAGCC 53.75%
Apta_1009 DNA ATAGGAGTCGACCGACCAGACCAACCCTACGCTCGTACCAACCAGATGACCTACGTGGCGTCTACATCTAGACTC 53.33%
Apta_863 DNA CTCCTCTGACTGTAACCACGCCCAGAAACAGCACCCTTACATCGACTGGACCTTCCGCGGCATAGGTAGTCCAGAAGCC 53.16%
Apta_1000 DNA ATAGGAGTCGACCGACCAGAACCGTTCCCATACTTCTCCAGCGATACTTAGTGCGTCTACATCTAGACTC 52.86%
Apta_798 DNA GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA 52.63%
Apta_1108 DNA GTGCTTAGGTGCAGAACGCACACACGCTCGGTATGACGTGTTCGCTACGGTATAATTGCAGGCGCGAGCACAACAG 52.63%
Apta_1293 DNA ATCCAGAGTGACGCAGCATGCCCTAGTTACTACTACTCTTTTTAGCAAACGCCCTCGCTTTGGACACGGTGGCTTAGT 52.56%
Apta_777 DNA GAGCCCTATCTCACACCGCACCCGCAAACTATCATCCTACATG 52.54%
Apta_818 DNA GGGCTGGCCAGATCAGACCCCGGATGATCATCCTTGTGAGAACCA 52.54%
Apta_1072 DNA TTGAAGTGACTCCCACCCCGCCCCACCGTCCTTGCCACCGTTCCGCCATAGCAGGT 52.54%
Apta_698 DNA AGCAGCACAGAGGTCAGATGCACTCGGACCCCATTCTCCTTCCATCCCTCATCCGTCCACCCTATGCGTGCTACCGTGAA 52.50%
Apta_867 DNA CTCCTCTGACTGTAACCACGCCACCGAGCCTACCACATGTGACATCCCAGGACATAGCTGGCATAGGTAGTCCAGAAGCC 52.50%
Apta_734 DNA TCCTCGATGCACCAGTTCACCTTATTTGCTTCTTCTCTCTGTTCTGACTGGGTGCTGAGGA 52.46%
Apta_1004 DNA ATAGGAGTCGACCGACCAGACCCGACCTCTCTTTCACTGTGACACAATGGTGCGTCTACATCTAGACTC 52.17%
Apta_1010 DNA ATAGGAGTCGACCGACCAGACCGACCCTCGTCGTACCAACTGATGACCTAGTGGCGTCTACATCTAGACTC 52.11%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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