AptaDB: Result

Interaction ID: 265

Aptamer sequence: GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT

Target unique ID: P08637

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_260	CLN0023	Protein	FCG3A_HUMAN	18 nM	DPBS with 0.05% BSA	21531729

Aptamer Sequence:	GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT
The optimal secondary structure in dot-bracket notation:	.(((.....(((((....)))))....)))..........
The centroid secondary structure in dot-bracket notation:	..((.....(((((....)))))....))...........

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_260	Description	CLN0023
Aptamer chemistry	DNA	Length	40 nt
GC content	50.0%	Molecular weight	12,686.94 Da
Molarity of 1 μg/μl solution	78.82 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P08637	Protein name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene name(s)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Organism	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Status	reviewed in uniprot database	Length	254
Mass	29,089	Activity regulation	N/A
Involvement in disease	Immunodeficiency 20 (IMD20)	Catalytic activity	N/A
PDB ID(s)	3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5VU0;5XJE;5XJF;5YC5;7SEG;
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).

No relevant experimental diagram	Interaction ID	265
	Target type	Protein
	Target unique ID	P08637
	Activity	18 nM
	Binding Conditions/Buffer	DPBS with 0.05% BSA
	Assay	N/A
	PubMed ID	21531729

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_259	DNA	GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT	75.00%
Apta_264	DNA	GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT	67.50%
Apta_72	DNA	AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT	57.50%
Apta_1176	DNA	AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT	57.50%
Apta_411	DNA	AGACGTAAGTTAATTGGACTTGGTCGTGTGCGGCACAGCGATTGAAAT	56.25%
Apta_987	DNA	GTACTGTCAATTGGAAGTGGTGTTACGTTGTGTAGTCAAATCAGTGC	55.32%
Apta_62	DNA	AGTCCGTGGTAGGGCAGGTTGGGGTGACT	55.00%
Apta_159	DNA	GCGTGCAGCATGACCACCGATGTCACACTTAATGAGAAT	55.00%
Apta_215	DNA	AGGAAGGCTTTAGGTCCGAGATCTCGGAAT	55.00%
Apta_916	DNA	GGCGTATGCAGTTTTGTAGGGTTATCAAGGCTTGACGATT	55.00%
Apta_928	DNA	GATTGAGTAGATAGTGGTTCTGTACGTAGTGAAAGAGTGG	55.00%
Apta_1094	DNA	GGAATCGTGGGTGGTAGGGTAGGGGATGCA	55.00%
Apta_1237	DNA	GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG	55.00%
Apta_861	DNA	CAGGTTGGTCTGGTTGGGTTTGGCTCCTGTGTACGCAACCTG	54.76%
Apta_340	DNA	TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA	54.55%
Apta_217	DNA	CGCCTGATTAGCGATACTCAGGCGTTGGGTGGGTGGGTGGG	53.66%
Apta_1162	DNA	AGAGGCTACAGCGATAAGTCGACATTGCTGACCGTACCTAGTAATACGT	53.06%
Apta_755	DNA	GGGGAGGGAGACACAGTCATGGAGCAGTTATTAGGGTGTACCGGGTGTAGT	52.94%
Apta_139	DNA	GATAAACGCCTTGATTAAAGGCCCAGTTCTTTAGGCCTACACGTGCTGCGACATTAATT	52.54%
Apta_145	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGA	52.50%

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