AptaDB: Result

Interaction ID: 264

Aptamer sequence: GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT

Target unique ID: P08637

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_259	CLN0021	Protein	FCG3A_HUMAN	25 nM	DPBS with 0.05% BSA	21531729

Aptamer Sequence:	GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT
The optimal secondary structure in dot-bracket notation:	((........)).............(((((....))))).
The centroid secondary structure in dot-bracket notation:	........................................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_259	Description	CLN0021
Aptamer chemistry	DNA	Length	40 nt
GC content	60.0%	Molecular weight	12,737.95 Da
Molarity of 1 μg/μl solution	78.51 μM	Number of G-quadruplexes	2
G-Score	20	Function	Targeted binding
Sequence	GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P08637	Protein name	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Gene name(s)	FCGR3A CD16A FCG3 FCGR3 IGFR3	Organism	Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Status	reviewed in uniprot database	Length	254
Mass	29,089	Activity regulation	N/A
Involvement in disease	Immunodeficiency 20 (IMD20)	Catalytic activity	N/A
PDB ID(s)	3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5VU0;5XJE;5XJF;5YC5;7SEG;
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG).

No relevant experimental diagram	Interaction ID	264
	Target type	Protein
	Target unique ID	P08637
	Activity	25 nM
	Binding Conditions/Buffer	DPBS with 0.05% BSA
	Assay	N/A
	PubMed ID	21531729

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_260	DNA	GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT	75.00%
Apta_264	DNA	GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT	67.50%
Apta_320	DNA	GCACTCTGTGGGGGTGGACGGGCCGGGT	57.50%
Apta_671	DNA	GCATCTGATCGGGTGTGGGTGGCGTAAAGG	57.50%
Apta_674	DNA	GCACGATGGGGAAAGGGTCCCCCTGGGTTG	57.50%
Apta_682	DNA	CCTTGTAGATCGGGTGTGGTTTGGCGTAGG	57.50%
Apta_683	DNA	GCAGTACGATCGGGGGTGGGTGGATGTAGG	57.50%
Apta_1138	DNA	GCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG	57.50%
Apta_910	DNA	TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA	56.36%
Apta_217	DNA	CGCCTGATTAGCGATACTCAGGCGTTGGGTGGGTGGGTGGG	56.10%
Apta_492	DNA	GCGAGGTGTTCGAGAGTTAGGGGCGACATGACCAAACGTT	55.00%
Apta_578	DNA	CACCAAGCGCAGGGAATTACATTGAAGTGTGGGATTGGCT	55.00%
Apta_673	DNA	GCAGTCCTAGATCGGGTGTGGCTGGCTTGG	55.00%
Apta_675	DNA	ACTGTCCGTCGGGTTTAGGGTGGCGTTCGG	55.00%
Apta_676	DNA	TCAGTCCCGATCAGGTGTGGGTGGCATTGG	55.00%
Apta_677	DNA	CCAAATGCGACGGGGCCTGTTTTAATGGGG	55.00%
Apta_813	DNA	TAGAGATATGACAGCGGGGAAGGTTAAGAGGCGCTAGGAG	55.00%
Apta_1013	DNA	ATCACGTATGGGGGGCCGGCATGAGGGCCGCGCGTGACA	55.00%
Apta_1065	DNA	CCTCGCTATGATGGAGTGCGTTTAGATCAGGGAACGGGTT	55.00%
Apta_1210	DNA	GGGGAGGCAGTGTGTTGTGTCGTGTGTGTGCTTGG	55.00%

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