AptaDB: Result

Interaction ID: 987

Aptamer sequence: GCCCGTCCGTATGGTGGGT

Target unique ID: O14786

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1039	SL2-A	Protein	NRP1_HUMAN	10 nM	PBS and 0.005% tween-20 solution mixture was used as the running buffer, and 50 mM NaOH as the regeneration buffer	22359573

Aptamer Sequence:	GCCCGTCCGTATGGTGGGT
The optimal secondary structure in dot-bracket notation:	(((((.((....)))))))
The centroid secondary structure in dot-bracket notation:	(((((.((....)))))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1039	Description	SL2-A
Aptamer chemistry	DNA	Length	19 nt
GC content	68.4%	Molecular weight	5,851.77 Da
Molarity of 1 μg/μl solution	170.89 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	GCCCGTCCGTATGGTGGGT
Applications	Identifying high affinity aptamer sequences for the biological molecules and targeting them as antagonist for cancer cell detection

Type	Detail	Type	Detail
Uniprot ID	O14786	Protein name	Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Gene name(s)	NRP1 NRP VEGF165R	Organism	Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Status	reviewed in uniprot database	Length	923
Mass	103,134	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	1KEX;2QQI;2QQM;2QQN;3I97;4DEQ;4RN5;5C7G;5IJR;5IYY;5J1X;5JGI;5JGQ;5JHK;5L73;6FMC;6FMF;6TKK;7JJC;7O1N;
Function	Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system.

No relevant experimental diagram	Interaction ID	987
	Target type	Protein
	Target unique ID	O14786
	Activity	10 nM
	Binding Conditions/Buffer	PBS and 0.005% tween-20 solution mixture was used as the running buffer, and 50 mM NaOH as the regeneration buffer
	Assay	N/A
	PubMed ID	22359573

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1038	DNA	CCCGTCCGTATGGTGGG	89.47%
Apta_1040	DNA	CAATTGGGCCCGTCCGTATGGTGGGT	73.08%
Apta_64	DNA	ACCGTGTGGAGGGTGTT	57.89%
Apta_211	DNA	GGTTGGTGTGGTTGG	57.89%
Apta_630	DNA	GACCAGGGCAAACGGTAGGGAGTGGTC	55.56%
Apta_63	DNA	GACCCGTGGTAGGGTAGGATGGGGTGGTC	55.17%
Apta_389	DNA	GCCTGTGGTGTTGGGGCGGGTGCG	54.17%
Apta_390	DNA	GGTGCGGCGGGACTAGTGGGTGTG	54.17%
Apta_318	DNA	CCCGTCTTCCAGACAAGAGTGCAGGG	53.85%
Apta_361	DNA	GGGAACGCCCGTATTGCTCGGTTCCC	53.85%
Apta_1019	DNA	ATCCCTGCAGTTTGGTAGGGTGCAGG	53.85%
Apta_320	DNA	GCACTCTGTGGGGGTGGACGGGCCGGGT	53.57%
Apta_671	DNA	GCATCTGATCGGGTGTGGGTGGCGTAAAGG	53.33%
Apta_673	DNA	GCAGTCCTAGATCGGGTGTGGCTGGCTTGG	53.33%
Apta_675	DNA	ACTGTCCGTCGGGTTTAGGGTGGCGTTCGG	53.33%
Apta_676	DNA	TCAGTCCCGATCAGGTGTGGGTGGCATTGG	53.33%
Apta_1196	DNA	GGGGGATGGGGG	52.63%
Apta_1197	DNA	GGGGGCATGGGGG	52.63%
Apta_346	DNA	GTACGTTCAGGAGCAGTGCGA	52.38%
Apta_757	DNA	GGTGGTGGTGGTTGTGGTGGTGG	52.17%

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