Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1219
Aptamer sequence: TGGGATACTGAACGGATGCCTTACAAAAAAAAAAAAAAAAAAAAACCTTATAGTTGTTGATTCCACCCG
Target unique ID: P14151
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1159 SC Circle Template Protein LYAM1_HUMAN N/A N/A 25826688
Structure information of aptamer
Aptamer Sequence: TGGGATACTGAACGGATGCCTTACAAAAAAAAAAAAAAAAAAAAACCTTATAGTTGTTGATTCCACCCG
The optimal secondary structure in dot-bracket notation: ((((((....(((.......................................)))....))))))....
The centroid secondary structure in dot-bracket notation: ((((((....(((.......................................)))....))))))....
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1159 Description SC Circle Template
Aptamer chemistry DNA Length 69 nt
GC content 33.3% Molecular weight 21,301.79 Da
Molarity of 1 μg/μl solution 46.94 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted therapy
Sequence TGGGATACTGAACGGATGCCTTACAAAAAAAAAAAAAAAAAAAAACCTTATAGTTGTTGATTCCACCCG
Applications Inhibit L-selectin
Target information
Type Detail Type Detail
Uniprot ID P14151 Protein name L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Gene name(s) SELL LNHR LYAM1 Organism L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Status reviewed in uniprot database Length 372
Mass 42,187 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
2LGF;3CFW;5VC1;
Function Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells.
Activity data

No relevant experimental diagram

 Interaction ID 1219
Target type Protein
Target unique ID P14151
Activity N/A
Binding Conditions/Buffer

N/A
Assay

N/A
PubMed ID 25826688
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1157 DNA ACCTTGTACTGGTTACCTTGGCTAAAAAAAAAAAAAAAAAAAAAGTAAGCCGAAGCCATTACGTTTAGC 55.07%
Apta_790 DNA GGGAGACAAGAATAAACGCTCAAGAAGTGAAAATGACAGAACACAACATTCGACAGGAGGCTCACAACAGGC 50.00%
Apta_811 DNA ATAGGAGTCACGACGACCAGAATCTAAAAATGGGCAAAGAAACAGTGACTCGTTGAGATACTTATGTGCGTCTACCTCTTGACTAAT 49.43%
Apta_988 DNA AAGGATGACTGACGACGATGGGAATGGAGAGGAAGGGGATATAGGTATGTTGGATGTAG 49.28%
Apta_931 DNA ATACGACTCACTATTAGGGACCACATAAACATGCATCGCTCAATAACGGGATATTGTTGTGCTAGACTACTGACTACAA 48.10%
Apta_932 DNA ATACGACTCACTATTAGGGATGTCCACCATATAGATCGATTTAAGTCCCTCGTTATTAATGCTAGACTACTGACTACAA 48.10%
Apta_685 DNA GGGGCAACAAACACGGAAGAAAATGAATCTACATACGTGGACATATATCCTGCCGCGTG 47.83%
Apta_919 DNA GGAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCG 47.83%
Apta_970 DNA TTATGTAGCATTTATGAAATTTTTAAATCAATTTACTATTGGTGGTATCC 47.83%
Apta_978 DNA GGCGATGAGAACGGGAGCCTGATGATACACACGAGCGATCGCTCATAAAAGCCGTGCCCG 47.83%
Apta_1068 DNA CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG 47.83%
Apta_232 DNA AGCAGCACAGAGGTCAGATGCTATGAGCAGATCCGATAGAAAGTTAATGCCCTAGAACATCCTATGCGTGCTACCGTGAA 47.50%
Apta_83 DNA GGCTTTACACTTTATGCTTCCGTAAAAACACAAACACACGCACATACATAAAATAACAATTTCACACAGGAAACAG 47.37%
Apta_1128 DNA GCCGAGATTGCACTTACTATCTCAATAGGGTAAAAAAAAAAAGTTGGTCCTATGGGTGGGTTGTTCAGTAATTGAATAAGCTGGTATGCGC 47.25%
Apta_1112 DNA ATCCAGAGTGACGCAGCAGGGCACATTGTTCACACACAGATCACATTACGGAAAACACAACTACACGAAATGTCGTTGGTGGCCC 47.06%
Apta_1017 DNA TAGGGAATTCGTCGACGGATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGGTCGACGCATGCGCCG 46.84%
Apta_458 DNA AGCTCCAGAAGATAAATTACAGGGAGAGTAAACTTTGCAAACACAACAATACCATTCCGGAACGTTCTTAACACAACTAGGATACTATGACCCC 46.81%
Apta_944 DNA ATACGACTCACTATTAGGGACAAAGCTGACAACCCTTTCATAATCTAACTACATTTATGTGCTAGACTACTGACTAC 46.75%
Apta_948 DNA TAGGGAAGAGAAGGACATATGATACTGGCCTTGACACCCTGTTGTGGCTTGATGACAATAACATTGACTAGTACATGACCACTTGA 46.51%
Apta_1031 DNA GGAGACCGCTTAAGCTTAAAGGAGCGGTTACGAATGCGATGACTTAGGTACCATTGCACTACGGTACCTAAACAGTTCCTTTGGATCCGAATTCGCCGC 46.46%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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