Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1102
Aptamer sequence: GGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTG
Target unique ID: Other-48
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1026 | Apta 3 | Other | Carcinoembryonic antigen (CEA) | 60.4 nM | N/A | 32527457 |
Structure information of aptamer
| Aptamer Sequence: | GGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTG |
| The optimal secondary structure in dot-bracket notation: | ................(((((.(((....))).))))). |
| The centroid secondary structure in dot-bracket notation: | ................(((((..((....))..))))). |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1026 | Description | Apta 3 |
| Aptamer chemistry | DNA | Length | 39 nt |
| GC content | 64.1% | Molecular weight | 12,173.76 Da |
| Molarity of 1 μg/μl solution | 82.14 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Target recognition |
| Sequence | GGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTG | ||
| Applications | Specific to CEA for use as radiopharmaceuticals in colorectal cancer diagnosis | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Target ID | Other-48 | Name | Carcinoembryonic antigen (CEA) |
Activity data
 |
Interaction ID | 1102 |
| Target type | Other | |
| Target unique ID | Other-48 | |
| Activity | 60.4 nM | |
| Binding Conditions/Buffer | N/A |
|
| Assay | Binding saturation curves of aptamers incubated with T84 cell line. Kd was calculated using nonlinear regression with Specific Binding equation |
|
| PubMed ID | 32527457 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1205 | DNA | GGCAGGTGGTGTTGGTTGGTTGTGCGTGGAGTTGG | |
| Apta_18 | DNA | TGGGGGGTTGGACGGGCGGGGCTGC | |
| Apta_146 | DNA | GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG | |
| Apta_1067 | DNA | GCGCGGTACCGCGCTAACGGAGGTTGCGTCCGT | |
| Apta_1210 | DNA | GGGGAGGCAGTGTGTTGTGTCGTGTGTGTGCTTGG | |
| Apta_1237 | DNA | GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG | |
| Apta_71 | DNA | GGCGAGTAGGTTGGTGTGGTTGGGGCTCGCC | |
| Apta_73 | DNA | GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC | |
| Apta_350 | DNA | GGTGGTGGTGGTTGTGGTGGTGGTGG | |
| Apta_393 | DNA | AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT | |
| Apta_1138 | DNA | GCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG | |
| Apta_335 | DNA | ACCGGGCGTACACCGTCGCGGCACATGTCTGAATGCGTTTAGTCTCTGTG | |
| Apta_942 | DNA | AGTGGGTAAGGTCTGGTGGATTGTGGACGGGGGGCGGGGCAGTGGCTTGA | |
| Apta_267 | DNA | GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG | |
| Apta_492 | DNA | GCGAGGTGTTCGAGAGTTAGGGGCGACATGACCAAACGTT | |
| Apta_507 | DNA | GGCGGGGCTACGAAGTAGTGATTTTTTCCGATGGCCCGTG | |
| Apta_1230 | DNA | GGCGATAGGCAGTGTTGCGGGGTCGGAGAGCGAGGTAATAGCGTGTATGGGTGCTGTGTG | |
| Apta_1254 | DNA | GGCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG | |
| Apta_1255 | DNA | GGCGCATGATCATTCGGTGGGTAAGGTGGTGGTAACGTTG | |
| Apta_1259 | DNA | GGCGCGGCATGGTGTGGACTCCAGGCGGTAGGGATGTCGT |
DEV TOOL
 |
 |
 |
 |