AptaDB: Result

Interaction ID: 942

Aptamer sequence: UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA

Target unique ID: Other-5

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_856	SE RNA	Other	Anti-acetylcholine Autoantibodies	60 nM	30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM MgCl2, 2 mM DTT, 1% BSA	9035104

Aptamer Sequence:	UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA
The optimal secondary structure in dot-bracket notation:	(((((((..(((..(((((((...))))))).....))).))).))))
The centroid secondary structure in dot-bracket notation:	(((((((..((((.(((((((...)))))))..)..))).))).))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_856	Description	SE RNA
Aptamer chemistry	RNA	Length	48 nt
GC content	68.8%	Molecular weight	15,529.31 Da
Molarity of 1 μg/μl solution	64.39 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA
Applications	Protect acetylcholine receptors on human cells from the effects of these antibodies.

Type	Detail	Type	Detail
Target ID	Other-5	Name	Anti-acetylcholine Autoantibodies

	Interaction ID	942
	Target type	Other
	Target unique ID	Other-5
	Activity	60 nM
	Binding Conditions/Buffer	30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM MgCl2, 2 mM DTT, 1% BSA
	Assay	Binding affinity
	PubMed ID	9035104
	Interaction ID	972
	Target type	Other
	Target unique ID	Other-19
	Activity	60 nM
	Binding Conditions/Buffer	30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10mM MgCl2, 2mM dithiothreitol, 1% BSA
	Assay	Binding affinity
	PubMed ID	9035104

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_366	RNA	GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC	56.25%
Apta_367	RNA	CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC	56.25%
Apta_660	RNA	UGGGAGGAGUGCUGCUCUCCAGGCACUCUUGUUGCUCGGA	56.25%
Apta_365	RNA	GGACCUAUGCAGUAGCCAGUGUGGACUGGGCUGCCCCCCC	54.17%
Apta_658	RNA	CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC	54.17%
Apta_460	RNA	GGAUGGCAGCGGAGAGUUGCUUGGAAUGCGUUAUAGUCUCUUAGGUGUGUACAGCCCACACCACUCUCC	53.62%
Apta_133	RNA	GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA	52.94%
Apta_3	DNA	CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC	52.08%
Apta_521	RNA	GGGUUGGGAAGAAACUGUGGCACUUCGGUGCCAGCAACCC	52.08%
Apta_703	RNA	GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG	52.08%
Apta_256	RNA	GGGCGCUAAGUCCUCGCUCAUGCGCGUCCCAUGGGGUAUAGAGGGGUCGAAGUGGACGCGCGACUCGGAUCCU	52.05%
Apta_38	RNA	GGUAGAUACGAUGGAUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA	51.56%
Apta_645	RNA	CUGGACGACGGGGACGCCACUGGACUAGGUAAGCCAGGACCGUACGUCGGGAGCCGUCAGAAUA	51.56%
Apta_315	RNA	GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA	50.98%
Apta_2	RNA	GGGCUUCUCUGGUUAGACCAGAUUUGAGCCUGGGAGCUCUCUGGCUAACUAGGGAACCC	50.85%
Apta_130	RNA	GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA	50.72%
Apta_353	RNA	GAAUUCCGCGUGUGCCAGCGAAAGUUGCGUAUGGGUCACAUCGCAGGCACAUGUCAUCUGGGCGGUCCGUUCGGGAUCC	50.63%
Apta_218	RNA	AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU	50.00%
Apta_303	RNA	CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG	50.00%
Apta_305	RNA	GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC	50.00%

ABOUT