Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1210
Aptamer sequence: CTAAGCAGGAAGGTATGGATTGGTTGCATTAG
Target unique ID: 5962
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1150 M13a Molecule Lysine 2.54 μM 10 mM Na2HPO4, 2 mM KH2PO4, 50 mM KCl, 5 mM MgCl2, 500 mM NaCl, pH 7.4 22881428
Structure information of aptamer
Aptamer Sequence: CTAAGCAGGAAGGTATGGATTGGTTGCATTAG
The optimal secondary structure in dot-bracket notation: ((((((((...(((....)))..)))).))))
The centroid secondary structure in dot-bracket notation: ((((((((...............)))).))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1150 Description M13a
Aptamer chemistry DNA Length 32 nt
GC content 43.8% Molecular weight 9,983.45 Da
Molarity of 1 μg/μl solution 100.17 μM Number of G-quadruplexes 2
G-Score 20 Function Target detection
Sequence CTAAGCAGGAAGGTATGGATTGGTTGCATTAG
Applications Recognize lysine
Target information
Type Detail Type Detail
PubChem ID 5962 Molecular name Lysine
Molecular formula C6H14N2O2 Molecular weight 146.19
IUPAC name (2S)-2,6-diaminohexanoic acid InChIKey KDXKERNSBIXSRK-YFKPBYRVSA-N
LogP -0.473 Topological polar surface area 89.34
Hydrogen bond acceptor 3 Hydrogen bond donor 3

Synonym(s):
L-lysine; lysine; 56-87-1; lysine acid; h-Lys-oh; (S)-Lysine; Aminutrin; (2S)-2,6-diaminohexanoic acid; L-(+)-Lysine; alpha-Lysine; Poly-L-lysine; (S)-2,6-Diaminohexanoic acid; Hydrolysin; Lysinum [Latin]; L-lys; Lisina [Spanish]; (S)-2,6-Diaminocaproic acid; L-Norleucine, 6-amino-; Lysine, L-; Lysinum; (S)-alpha,epsilon-Diaminocaproic acid; Lysine [USAN:INN]; LYS (IUPAC abbreviation); L-2,6-Diaminocaproic acid; Hexanoic acid, 2,6-diamino-, (S)-; lys; a-Lysine; 2,6-Diaminohexanoic acid, (S)-; L-Lysin; BRN 1722531; 25104-18-1; CHEBI:18019; AI3-26523; 6-ammonio-L-norleucine; lysin; 12798-06-0; L-Lysine base; MFCD00064433; HSDB 2108; L-2,6-Diaminocaproate; Lisina; L-LYSINE, MONOACETATE; (+)-S-Lysine; 3H-Lysine; 2,6-diaminohexanoate; (S)-(+)-Lysine; EINECS 200-294-2; lysina; L-Lysine, labeled with tritium; Ketporofen lysine; L-aLysine; .alpha.-Lysine; 1ozv; 1yxd; 3h-l-lysine; 6-amino-Aminutrin; NCGC00164527-01; Poly-(L-lysine); H-Lys; (-)-lysine; 6-amino-L-Norleucine; a,e-Diaminocaproic acid; Lysine (USAN/INN); Alpha-poly-(L-lysine); L-2,6-Diainohexanoate; (S)-a,e-Diaminocaproate; DSSTox_CID_3232; L-Lysine, >=97%; bmse000043; bmse000914; Epitope ID:136017; (S)-2,6-Diaminohexanoate; L-2,6-Diainohexanoic acid; CHEMBL8085; DSSTox_RID_76935; DSSTox_GSID_23232; GTPL724; (S)-2,6-diamino-Hexanoate; (S)-a,e-Diaminocaproic acid; 4-04-00-02717 (Beilstein Handbook Reference); L-Lysine, analytical standard; L-Lysine, >=98%, FG; DTXSID6023232; (S)-2,6-diamino-Hexanoic acid; L-Lysine, >=98% (TLC); BDBM217367; (2S)-2,6-Diamino-hexanoic acid; ACT02654; HY-N0469; L-H2N(CH2)4CH(NH2)COOH; ZINC1532522; Tox21_112158; Ethyl3,5-dichloro-4-propoxybenzoate; s5630; .alpha.,.epsilon.-Diaminocaproic acid; AKOS006239081; AKOS015855172; CCG-266180; CS-W019758; DB00123; MCULE-3226089160; CAS-56-87-1; L-Lysine solution, purum, 50% in H2O; NCGC00166296-02; 20166-34-1; AC-14492; AS-11733; (S)-.alpha.,.epsilon.-Diaminocaproic acid; L-Lysine, crystallized, >=98.0% (NT); AM20100376; L0129; L-Lysine, Vetec(TM) reagent grade, >=98%; A20652; C00047; D02304; 064L433; A904498; A919375; J-521651; (S)-2,6-Diaminocaproic acid;(S)-(+)-Lysine;Lysine; Q20816880; F0001-1472; UNII-0O72R8RF8A component KDXKERNSBIXSRK-YFKPBYRVSA-N; UNII-AI4RT59273 component KDXKERNSBIXSRK-YFKPBYRVSA-N; UNII-K3Z4F929H6 component KDXKERNSBIXSRK-YFKPBYRVSA-N; UNII-N7U7BXP2OI component KDXKERNSBIXSRK-YFKPBYRVSA-N; 0013CD6B-1671-4369-B1BE-F531611E50C7

Activity data
Interaction ID 1210
Target type Molecule
Target unique ID 5962
Activity 2.54 μM
Binding Conditions/Buffer

10 mM Na2HPO4, 2 mM KH2PO4, 50 mM KCl, 5 mM MgCl2, 500 mM NaCl, pH 7.4
Assay

Binding curve of M13a to PSL determined by static adsorption method
PubMed ID 22881428
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_65 DNA CTACCGTGGTAGGGAAGGTTGGAGTGTAG 62.50%
Apta_691 DNA CGACGCGCGTTGGTGGTGGATGGTGTGTTACACGTGTTGT 57.50%
Apta_1206 DNA GGCAGCAGCAATGTAACACTGTGTGTATGTGTTGG 57.14%
Apta_66 DNA TACCGTGGTAGGGAAGGTTGGAGTGTA 56.25%
Apta_72 DNA AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT 56.25%
Apta_74 DNA GGACAGTAGGTTGGTGTGGTTGGGGCTGTCC 56.25%
Apta_75 DNA CACTGGTAGGTTGGTGTGGTTGGGGCCAGTG 56.25%
Apta_676 DNA TCAGTCCCGATCAGGTGTGGGTGGCATTGG 56.25%
Apta_639 DNA CTAAGCACAGGGAAACCAGCTAATGAGTTAGGCCTGTCCCCCACG 55.56%
Apta_578 DNA CACCAAGCGCAGGGAATTACATTGAAGTGTGGGATTGGCT 55.00%
Apta_579 DNA ACTGAGGGCACGGACAGGAGGGGGAGAGATGGCGTGAGGT 55.00%
Apta_1257 DNA CGACGCACAGTCGCTGGTGCGTACCTGGTTGCCGTTGTGT 55.00%
Apta_1286 DNA CTATACGTATTCTAACTTGTTACGTATTGGTCTCTTATTG 55.00%
Apta_1032 DNA TGGCAAGAGGGTGTGCTTAAGGTGGACACGGTGGCTTAG 53.85%
Apta_845 DNA CCAAACGCGCTGGTTTGGAATGCTTAGAGTTTGATCGATGCCTAA 53.33%
Apta_12 DNA TGAGGGGGTGGGTGGGACGGGTTGG 53.12%
Apta_30 DNA AGAGGGGGGGGTGGAGGGGGCTAGA 53.12%
Apta_326 DNA GCAACAGGGTATCCAAAGGATCAAA 53.12%
Apta_419 DNA ATCAGGGCTAAAGAGTGCAGAGTTACTTAG 53.12%
Apta_679 DNA CAGGTGGCAGATCGGGTGTGGGTGGCCTGG 53.12%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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