Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_345 | Aptamer 110 | Protein | ADRB1_RAT | 100 nM | Tris buffer pH 7.3, 0.1% Tween-20, DMEM, 0.1% Tween-20 | 21868696 |
Structure information of aptamer
| Aptamer Sequence: | ACAGTAACCGCGTGAGGTCGA |
| The optimal secondary structure in dot-bracket notation: | ......(((......)))... |
| The centroid secondary structure in dot-bracket notation: | ......(((......)))... |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_345 | Description | Aptamer 110 |
| Aptamer chemistry | DNA | Length | 21 nt |
| GC content | 57.1% | Molecular weight | 6,720.15 Da |
| Molarity of 1 μg/μl solution | 148.81 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Targeted therapy |
| Sequence | ACAGTAACCGCGTGAGGTCGA | ||
| Applications | Neutralize cardiomyopathy | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P18090 | Protein name | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) |
| Gene name(s) | Adrb1 Adrb1r | Organism | Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) |
| Status | reviewed in uniprot database | Length | 466 |
| Mass | 50,472 | Activity regulation | N/A |
| Involvement in disease | N/A | Catalytic activity | N/A |
| PDB ID(s) | N/A |
 |
Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. |
Activity data
 |
Interaction ID | 350 |
| Target type | Protein | |
| Target unique ID | P18090 | |
| Activity | 100 nM | |
| Binding Conditions/Buffer | Tris buffer pH 7.3, 0.1% Tween-20, DMEM, 0.1% Tween-20 |
|
| Assay | Concentration dependent effect of 0-100 nM aptamer 110 on beta1-AABs prepared from a patient with DCM |
|
| PubMed ID | 21868696 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1160 | DNA | TTCAGTATCCCACGGGTGGAATCA | |
| Apta_198 | DNA | AGGAAGGCTTTAGGTCTGAG | |
| Apta_324 | DNA | CAAACAATCAAACAGCAGTGGGGTG | |
| Apta_324 | DNA | CAAACAATCAAACAGCAGTGGGGTG | |
| Apta_419 | DNA | ATCAGGGCTAAAGAGTGCAGAGTTACTTAG | |
| Apta_673 | DNA | GCAGTCCTAGATCGGGTGTGGCTGGCTTGG | |
| Apta_682 | DNA | CCTTGTAGATCGGGTGTGGTTTGGCGTAGG | |
| Apta_200 | DNA | AGGAAGGCTTTAGGT | |
| Apta_207 | DNA | AGGAAGGCTTTAGGTGGAAT | |
| Apta_209 | DNA | AAGGCTTTAGGTCTG | |
| Apta_1038 | DNA | CCCGTCCGTATGGTGGG | |
| Apta_669 | DNA | AACGTGGGAGGGCGGTGGTGTTGAA | |
| Apta_630 | DNA | GACCAGGGCAAACGGTAGGGAGTGGTC | |
| Apta_1206 | DNA | GGCAGCAGCAATGTAACACTGTGTGTATGTGTTGG | |
| Apta_60 | DNA | GGAATGAGTGCCCTGCAAGCGAGGGCTAGC | |
| Apta_191 | DNA | AGGAAGGCTTTACCTCTGAGATCTCGGAAT | |
| Apta_540 | DNA | ACGTGTTGTCTCTCTGTGTCTCGT | |
| Apta_671 | DNA | GCATCTGATCGGGTGTGGGTGGCGTAAAGG | |
| Apta_676 | DNA | TCAGTCCCGATCAGGTGTGGGTGGCATTGG | |
| Apta_679 | DNA | CAGGTGGCAGATCGGGTGTGGGTGGCCTGG |
DEV TOOL
 |
 |
 |
 |