AptaDB: Result

Interaction ID: 1046

Aptamer sequence: TGGCGCTGCCCCTAGTCTCCGGCTGATAGCTGCTTCTTGG

Target unique ID: P01266

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_963	T-6	Protein	THYG_HUMAN	7.07 μM	TGK, Tris-HCl, BBS, and PBS	33303143

Aptamer Sequence:	TGGCGCTGCCCCTAGTCTCCGGCTGATAGCTGCTTCTTGG
The optimal secondary structure in dot-bracket notation:	.(((...)))((.((....(((((...)))))...)).))
The centroid secondary structure in dot-bracket notation:	........................................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_963	Description	T-6
Aptamer chemistry	DNA	Length	40 nt
GC content	62.5%	Molecular weight	12,237.81 Da
Molarity of 1 μg/μl solution	81.71 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	TGGCGCTGCCCCTAGTCTCCGGCTGATAGCTGCTTCTTGG
Applications	CE-based detection validated the application feasibility of aptamer for Tg detection

Type	Detail	Type	Detail
Uniprot ID	P01266	Protein name	Thyroglobulin (Tg)
Gene name(s)	TG	Organism	Thyroglobulin (Tg)
Status	reviewed in uniprot database	Length	2768
Mass	304,790	Activity regulation	N/A
Involvement in disease	Thyroid dyshormonogenesis 3 (TDH3)	Catalytic activity	N/A
PDB ID(s)	6SCJ;7B75;
Function	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

No relevant experimental diagram	Interaction ID	1046
	Target type	Protein
	Target unique ID	P01266
	Activity	7.07 μM
	Binding Conditions/Buffer	TGK, Tris-HCl, BBS, and PBS
	Assay	N/A
	PubMed ID	33303143

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_673	DNA	GCAGTCCTAGATCGGGTGTGGCTGGCTTGG	60.00%
Apta_1263	DNA	CCCCGCTGCCCGTGTTCCGTCCTCCCTTGCTGTGTGTGCG	57.50%
Apta_833	DNA	ATTTCGCCCCCGTGTTCCGACTGGTATCTTCACGTCTTCGAGTGT	55.56%
Apta_143	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAGTTTCG	55.10%
Apta_1027	DNA	GGAGCTACGTTTAGCGAGTCCGACGCTCGGTGCCTCTTC	55.00%
Apta_938	DNA	TTGCCCACCTCCCTGTGCGGGCCACAGAGCAGCAGTGTCGTG	54.76%
Apta_779	DNA	TACGGGCTGGATCCACTGTTACGGCGTGTATCCGCTATCAA	53.66%
Apta_255	DNA	TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT	53.33%
Apta_820	DNA	TCCCACGATCTCATTAGTCTGTGGATAAGCGTGGGACGTCTATGA	53.33%
Apta_835	DNA	TATGGCGTGGCAAGCTTGGCCCGCTTCTCAAGCATGGTTATCTAC	53.33%
Apta_165	DNA	TGGACGAACTGCCCTCAGCTACTTTCATGTTGCTGACGCA	52.50%
Apta_167	DNA	TGCTCCTTGGCCTTAGCCCTGGAACCATCAATCCTCTTCG	52.50%
Apta_541	DNA	CACGTGTTGTCTCTCTGTGTCTCGTG	52.50%
Apta_542	DNA	GCACGTGTTGTCTCTCTGTGTCTCGTGC	52.50%
Apta_543	DNA	GGCACGTGTTGTCTCTCTGTGTCTCGTGCC	52.50%
Apta_676	DNA	TCAGTCCCGATCAGGTGTGGGTGGCATTGG	52.50%
Apta_679	DNA	CAGGTGGCAGATCGGGTGTGGGTGGCCTGG	52.50%
Apta_917	DNA	TCGATTTCCTTAGTTGTCTTCCTTAGTGAG	52.50%
Apta_1204	DNA	GGCACGATGTGGCTACATCGATCGCGGTACTGGTG	52.50%
Apta_1205	DNA	GGCAGGTGGTGTTGGTTGGTTGTGCGTGGAGTTGG	52.50%

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