Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 676
Aptamer sequence: GGCAUCGGAAAGUGGGUUGAUGUAAGUAACAGGCGAUGCC
Target unique ID: 6274
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_633 His945 Molecule Histidine 12 μM 50 mM Hepes (pH 7.0), 250 mM NaCl, 5 mM each CaCl2 and MgCl2, and 1 mM glycine 15999244
Structure information of aptamer
Aptamer Sequence: GGCAUCGGAAAGUGGGUUGAUGUAAGUAACAGGCGAUGCC
The optimal secondary structure in dot-bracket notation: (((((((....((...............))...)))))))
The centroid secondary structure in dot-bracket notation: (((((((..........................)))))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_633 Description His945
Aptamer chemistry RNA Length 40 nt
GC content 52.5% Molecular weight 13,017.80 Da
Molarity of 1 μg/μl solution 76.82 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence GGCAUCGGAAAGUGGGUUGAUGUAAGUAACAGGCGAUGCC
Applications Binding to L-Histidine
Target information
Type Detail Type Detail
PubChem ID 6274 Molecular name Histidine
Molecular formula C6H9N3O2 Molecular weight 155.15
IUPAC name (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid InChIKey HNDVDQJCIGZPNO-YFKPBYRVSA-N
LogP -0.636 Topological polar surface area 92
Hydrogen bond acceptor 3 Hydrogen bond donor 3

Synonym(s):
L-histidine; histidine; 71-00-1; H-His-OH; glyoxaline-5-alanine; L-(-)-Histidine; Anti-rheuma; Istidina; S-Histidine; (L)-Histidine; Histidine (VAN); histidina; (S)-4-(2-Amino-2-carboxyethyl)imidazole; Histidinum; L-Histidin; (S)-alpha-amino-1H-imidazole-4-propanoic acid; HISTIDINE, L-; Histidine [USAN:INN]; Histidinum [INN-Latin]; (S)-Histidine; Histidina [INN-Spanish]; (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid; L-beta-(4-Imidazolyl)alanin; 4-(2-Amino-2-carboxyethyl)imidazole; FEMA No. 3694; his; L-hystidine; 1H-Imidazole-4-alanine, (S)-; L-Hisidine; (S)-2-Amino-3-(4-imidazolyl)propionsaeure; L-beta-(4-Imidazolyl)-alpha-alanin; (S)-alpha-Amino-1H-imidazole-4-propionic acid; L-His; L-Alanine, 3-(1H-imidazol-4-yl)-; UNII-4QD397987E; AI3-26558; alpha-Amino-4(or 5)-imidazolepropionic acid; (S)-2-Amino-3-(4-imidazolyl)propionic acid; MFCD00064315; alpha-Amino-1H-imidazole-4-propionic acid, (S)-; 1H-Imidazole-4-propanoic acid, alpha-amino-, (S)-; (S)-a-Amino-1H-imidazole-4-propanoic acid; CHEBI:15971; 4QD397987E; Histidine (L-Histidine); 7006-35-1; Histidine, monohydrochloride; HSDB 1810; EINECS 200-745-3; NSC 137773; 1hsl; 1lag; NSC-137773; [3H]histidine; Histidine,(S); [3H]-histidine; (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride; L-His-OH; 2-Amino-3-(1H-imidazol-4-yl)-propionic acid; Histidine (USP/INN); L-Histidine (JP17); L-2-Amino-3-(4-imidazolyl)propionic acid; Lopac-H-8125; bmse000039; bmse000976; bmse001015; L-Histidine (H-His-OH); amino-4-imidazoleproprionate; SCHEMBL3259; Lopac0_000566; US9138393, Histidine; US9144538, Histidine; (S)1H-Imidazole-4-alanine; CHEMBL17962; (S)-1H-Imidazole-4-alanine; BDBM7953; GTPL3310; GTPL4670; L-Histidine, non-animal source; Imidazole C-4(5) deriv. 5; amino-4-imidazoleproprionic acid; DTXSID9023126; amino-1H-imidazole-4-propanoate; L-Histidine, p.a., 98.5%; BDBM181118; L-Histidine, Cell Culture Reagent; 3-(1H-imidazol-4-yl)-L-Alanine; HY-N0832; ZINC6661227; amino-1H-imidazole-4-propanoic acid; AKOS015854051; AKOS026676613; AM81801; CCG-204656; CS-7781; DB00117; MCULE-4083000888; SDCCGSBI-0050549.P002; (S)-a-Amino-1H-imidazole-4-propanoate; NCGC00015518-01; NCGC00162189-01; NCGC00162189-02; NCGC00162189-05; AC-35086; AS-14171; (S)-alpha-Amino-1H-imidazole-4-propanoate; (S)-alpha-Amino-1H-imidazole-4-propionate; L-Histidine, BioUltra, >=99.5% (NT); H0149; L-Histidine, SAJ special grade, >=98.5%; S3989; (S)-2-Amino-3-(imidazol-4-yl)propanoic acid; C00135; D00032; D70843; H-2310; L-Histidine, ReagentPlus(R), >=99% (TLC); M02982; (2S)-2-amino-3-(imidazol-4-yl)propanoic acid; 88842-EP2289892A1; 88842-EP2305825A1; L-Histidine, Vetec(TM) reagent grade, >=99%; (S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid; 064H315; Q485277; B81AEDB0-EACA-4296-9BAB-52D60F137FFB; 1H-Imidazole-4-propanoic acid, .alpha.-amino-, (S)-; F8881-8926; F8889-0575; L-Histidine, certified reference material, TraceCERT(R); Z955123622; Histidine, European Pharmacopoeia (EP) Reference Standard; UNII-0O72R8RF8A component HNDVDQJCIGZPNO-YFKPBYRVSA-N; UNII-N7U7BXP2OI component HNDVDQJCIGZPNO-YFKPBYRVSA-N; UNII-QU6SDF3Q03 component HNDVDQJCIGZPNO-YFKPBYRVSA-N; L-Histidine, United States Pharmacopeia (USP) Reference Standard; L-Histidine, Pharmaceutical Secondary Standard; Certified Reference Material; L-Histidine, cell culture tested, meets EP, USP testing specifications, from non-animal source; L-Histidine, PharmaGrade, Ajinomoto, EP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture

Activity data
Interaction ID 676
Target type Molecule
Target unique ID 6274
Activity 12 μM
Binding Conditions/Buffer

50 mM Hepes (pH 7.0), 250 mM NaCl, 5 mM each CaCl2 and MgCl2, and 1 mM glycine

Assay

Affinity chromatography of RNA on 0.6 mM histidine-Sepharose

PubMed ID 15999244
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_51 RNA GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC 60.00%
Apta_1167 RNA GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC 60.00%
Apta_378 RNA UGCUCUUAGAAUGGGACUAAGACACGGGAC 55.00%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 55.00%
Apta_647 RNA GGAUCCCGACUGGCGAGAGCCAGGUAACGAAUGGAUCC 55.00%
Apta_1292 RNA GGCACGUGUAUUACCCUAGUGGUCGACGUGCC 55.00%
Apta_859 RNA GGGAGUCUGAAGUCGGACUUGUUAUCAAUUCACUUCAGACU 53.66%
Apta_371 RNA GGCAGACCAUACGGGAGAGAAACUUGCC 52.50%
Apta_560 RNA GGAAGAGAUGGCGACUAAAACGACUUGUCGC 52.50%
Apta_606 RNA CGGUUGGAUGGGUGUUGGUGGUUUGUUGAGUCCAGGCGGC 52.50%
Apta_242 RNA GCUUCCAGGAAGAGAAGUGUCAUGUGAUCAGUCCUGGUGGGUGG 52.27%
Apta_1122 RNA ACAACCCGGAACAACGUCUAACAGUGUACCAUAACCCGGCAUUCA 51.11%
Apta_1121 RNA GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC 51.06%
Apta_131 RNA GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA 50.98%
Apta_132 RNA GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA 50.98%
Apta_134 RNA GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA 50.98%
Apta_135 RNA GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA 50.98%
Apta_315 RNA GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA 50.98%
Apta_2 RNA GGGCUUCUCUGGUUAGACCAGAUUUGAGCCUGGGAGCUCUCUGGCUAACUAGGGAACCC 50.85%
Apta_90 RNA ACAACCUAAAUGCGACGUUGGGUCAAAAACGUGAA 50.00%