AptaDB: Result

Interaction ID: 1204

Aptamer sequence: ACGAGUCUGGUCCUUCCUCCCUAAUUGCUGUUGAGGUAUCGGCUACAACAA

Target unique ID: Q15063

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1144	PNDA-4	Protein	POSTN_HUMAN	1 nM	40 mmol/l HEPES, pH 7.2, 102 mmol/l NaCl, 5 mmol/l mol/lgCl2, 5 mmol/l KCl	23511245

Aptamer Sequence:	ACGAGUCUGGUCCUUCCUCCCUAAUUGCUGUUGAGGUAUCGGCUACAACAA
The optimal secondary structure in dot-bracket notation:	.......(((((...((((.............))))....)))))......
The centroid secondary structure in dot-bracket notation:	...................................................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1144	Description	PNDA-4
Aptamer chemistry	RNA	Length	51 nt
GC content	49.0%	Molecular weight	16,221.59 Da
Molarity of 1 μg/μl solution	61.65 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	ACGAGUCUGGUCCUUCCUCCCUAAUUGCUGUUGAGGUAUCGGCUACAACAA
Applications	Inhibits breast cancer growth and metastasis

Type	Detail	Type	Detail
Uniprot ID	Q15063	Protein name	Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)
Gene name(s)	POSTN OSF2	Organism	Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)
Status	reviewed in uniprot database	Length	836
Mass	93,314	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	5WT7;5YJG;5YJH;
Function	Induces cell attachment and spreading and plays a role in cell adhesion.

	Interaction ID	1204
	Target type	Protein
	Target unique ID	Q15063
	Activity	1 nM
	Binding Conditions/Buffer	40 mmol/l HEPES, pH 7.2, 102 mmol/l NaCl, 5 mmol/l mol/lgCl2, 5 mmol/l KCl
	Assay	Binding affinities were determined using 32P-labeled PNDAs and varying hPN concentrations
	PubMed ID	23511245

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1141	RNA	ACGAGUCUGGUCCUUCCUUUGACGACUAUUGUUUGGUAUCGAUCAACAACAA	73.08%
Apta_1143	RNA	ACGAGUUGUCGCAUGUGCGGUUCAGUCUGGUCCUUCAGCACCGUACAACAA	56.86%
Apta_384	RNA	AUGAUCAAUCGCCUCAAUUCGACAGGAGGCUCAC	54.90%
Apta_1142	RNA	ACGAGUCACACGUUGAUGACUGGAUGGUAGUUAAAGAGGGUGGGGCAACAA	54.90%
Apta_1	RNA	ACGAAGCUUGAUCCCGUUUGCCGGUCGAUCGCUUCGA	52.94%
Apta_695	RNA	AUUGGAUCGGUAGUAUAGGUGAGACACUUCAUGCCUUUGUUGCAGGCUGGGGUGAAGGCGCUACAUGGCGUCUGAAA	51.95%
Apta_136	RNA	CGUGUCGUCCUGGUACGAUUUGGUAUAUAACCGUGGCUUUUCGACA	50.98%
Apta_367	RNA	CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC	50.98%
Apta_632	RNA	GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC	50.98%
Apta_1168	RNA	GCGACUACGGUGAGGGUCGGGUCCAGUAGCUUCGGCUACUGUUGAGUAGAGUGUGGGCUCCGUAGUCGC	50.72%
Apta_80	RNA	GCAAUGGUACGGUACUUCCUUUGGAAGAUAGCUGGAGAACUAACCAAAAGUGCACGCUACUUUGCUAA	50.00%
Apta_594	RNA	GGGCUAUUGCUGGAGGGGCGCCACAUGAAAGUGGUGGUUGGGUGCGGUCGGCGAUAGCUC	50.00%
Apta_1056	RNA	GUCAUGUUGUGUUGUGGUCCAUCCUUUUCUACGCCAGUCGAGUCUGUAGCGUGGGAGUAAACUGAACGGUCAGACAGGA	49.37%
Apta_1290	RNA	GCGCGAGAAACGGUCACUAGAAUAGUGGGCCGUCAUGCUAACGCCUCUUUCGGUGUUGGGGAAUAUUGGCCAAUCGAGU	49.37%
Apta_496	RNA	GGGCUAGCUGAUCGUACCCAGUAGCGUGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC	49.28%
Apta_576	RNA	GGCACCAAAGCUGAAGUAGCGGGAUAACUCAAAUUACUUUAGGUGUAUGAAGGUGAAACUAGCAAUGAA	49.28%
Apta_2	RNA	GGGCUUCUCUGGUUAGACCAGAUUUGAGCCUGGGAGCUCUCUGGCUAACUAGGGAACCC	49.15%
Apta_88	RNA	AAUAACCUUAAUGCGACGUUGGUUUGUCAACAACG	49.02%
Apta_98	RNA	CGAUGCGGUCUCAUGCGUCGAGUGUGAGUUUACCUUCG	49.02%
Apta_172	RNA	GGAGACAUCCCUCUUGUUGGUGGUGCCGUGUGGAUGUCUC	49.02%

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