International Journal of Molecular Sciences · 2025
Sequence evidence
IKKIVSKIKKLLNH
IKKIVSKIKKLL-NH2
Experimental observations
The tumor volume decreased 21.44% ... after treatment with L-K5 at doses of 2.5 ... mg/kg (Section 2.1).
The tumor volume decreased ... 23.44% ... after treatment with L-K5 at doses of ... 5 ... mg/kg (Section 2.1).
The tumor volume decreased ... 32.6% after treatment with L-K5 at doses of ... 10 mg/kg (Section 2.1).
The inhibition rates were 18.69% ... in the L-K5 groups at 2.5 ... mg/kg (Section 2.1).
The inhibition rates were ... 26.17% ... in the L-K5 groups at ... 5 ... mg/kg (Section 2.1).
The inhibition rates were ... 46.73% ... in the L-K5 groups at ... 10 mg/kg (Section 2.1).
L-K5 at doses of 2.5 ... mg/kg decreased the release of IL-10 by 14.14% (Section 2.1).
L-K5 at doses of ... 5 ... mg/kg decreased the release of IL-10 by ... 24.42% (Section 2.1).
L-K5 at doses of ... 10 mg/kg decreased the release of IL-10 by ... 29.2% (Section 2.1).
L-K5 at doses of 2.5 ... mg/kg decreased ... Arg-1 by 46.62% (Section 2.1).
L-K5 at doses of ... 5 ... mg/kg decreased ... Arg-1 by ... 60.36% (Section 2.1).
L-K5 at doses of ... 10 mg/kg decreased ... Arg-1 by ... 63.7% (Section 2.1).
cell viability was greater than 80% when the concentrations of ... L-K5 ... were 10 and 20 μM (Section 2.2, Figure S1A).
10 μM ... L-K5 reduced the IL-10 content by 59.6% (Section 2.2).
20 μM L-K5 reduced the IL-10 content by ... 62.3% (Section 2.2).
10 μM ... L-K5 reduced ... Arg-1 by 83.0% (Section 2.2).
20 μM L-K5 reduced ... Arg-1 by ... 84.9% (Section 2.2).
L-K5 exhibited the most significant inhibitory effect, with inhibition rates of 63.3% ... at peptide concentrations of 10 ... μM (Section 2.3).
L-K5 exhibited the most significant inhibitory effect, with inhibition rates of ... 70.6% at peptide concentrations of ... 20 μM (Section 2.3).
KLF4 expression was downregulated by approximately 80% in IL4-induced U937 macrophages treated with 10 and 20 μM of ... L-K5 (Section 2.3).
L-K5 at peptide concentrations of 10 and 20 μM reduced the phosphorylation of STAT6 by approximately 76% (Section 2.3).
the viability of MCF-7 cells was greater than 80% after treatment with 10 and 20 μM of ... L-K5 (Section 2.4, Figure S1B).
The polarized M2 macrophages treated with 10 ... μM L-K5 reduced MCF-7 cell migration by 80.8% (Section 2.4).
The polarized M2 macrophages treated with ... 20 μM L-K5 reduced MCF-7 cell migration by ... 95.1% (Section 2.4).
L-K5 ... at a concentration of 20 μM reduced the TGF-β1 levels by ... 76.3% (Section 2.4).
L-K5 ... at a concentration of 20 μM reduced the EGF level by ... 88% (Section 2.4).
L-K5 exhibited the best inhibition, with decreases of 54.7% ... when the L-K5 concentration was 10 ... μM (Section 2.4).
L-K5 exhibited the best inhibition, with decreases of ... 73% when the L-K5 concentration was ... 20 μM (Section 2.4).
Treatment with L-K5 ... at a concentration of 20 μM downregulated pERK expression by 91.2% (Section 2.4).
Treatment with 20 μM L-K5 ... reduced snail mRNA expression by 69.1% (Section 2.4).
L-K5 (20 μM) had the greatest inhibitory effect (74.4%) on twist mRNA (Section 2.4).
The protein expression was downregulated by approximately 65% after treatment with the three peptides compared to the IL-4-treated group (Section 2.4).
L-K5 (10 μM ...) increased the protein expression of E-cadherin by 66.3% (Section 2.4).
L-K5 (... 20 μM) increased the protein expression of E-cadherin by ... 69.7% (Section 2.4).
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.
