PepDiana
Back to Evidence
Primary experimental recordPositive observation

PMC12429139::ACT025446

L-K5

Evidence text

Paper-level observation

KLF4 expression was downregulated by approximately 80% in IL4-induced U937 macrophages treated with 10 and 20 μM of ... L-K5 (Section 2.3).
textConfidence: medium

Assay observation

Activity
Immunomodulatory
Subtype
Anti-inflammatory
Measure
percent_inhibition
Comparator
~
Raw observation
~80%
Normalized measurement
~80%
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Homo sapiens
Assay method
Not reported by source
Sequence
IKKIVSKIKKLLNH
Standardization
ready simple

Source publication

Lysine-Leucine-Rich Frog Skin Antimicrobial Peptides Inhibit Breast Cancer Metastasis by Reprogramming Tumor-Associated Macrophage Polarization.

International Journal of Molecular Sciences · 2025

DOI 10.3390/ijms26178627 PMC12429139
Parent mention

Related peptide identities

PEPDIA-PLP-001298

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.