Integrated scope
PepDiana integrates multifunctional peptide sequences, bioactivities, provenance, literature evidence, and structural annotations from curated public resources.
About PepDiana
Multifunctional Peptide Database
PepDiana is named after Diana, the moon goddess associated with multiple phases. The database presents moonlight peptides, molecules with multiple biological activities, as a structured knowledge map for sequence, structure, evidence, and source-aware research.
Database overview
Evidence first
Gold, Silver, and Bronze annotation tiers make provenance depth visible before users export records or build downstream models.
Research workflows
The interface supports browsing, sequence and keyword search, multi-select filters, favorites, comparison, analytics, citation, and export.
Local development stack
The current frontend is built with Next.js, TypeScript, and Tailwind CSS, backed by FastAPI and PostgreSQL.
What researchers can do
- Search peptides by sequence motif, name, identifier, or evidence keyword.
- Filter by activity class, source database, annotation level, quality, length, mass, and structure type.
- Save local favorites, compare shortlists, export current pages or full matching result sets.
- Inspect detail pages with citations, standards, provenance, raw annotations, and derived molecular notations.
- Use Analytics heatmaps and matrices to enter Browse through evidence-backed drilldowns.
Methodology and data quality
Data layers
Integrated records, Primary-literature peptide identities, and evidence without a safely standardized sequence are stored at distinct grains. Sequence links connect layers without allowing one layer to overwrite another.
Traceability
Integrated activities retain stable source IDs and record URLs. Primary observations retain publication, mention, activity-record, table/figure/location, raw value, and evidence-sentence provenance.
Versioned computation
Physicochemical descriptors and ProForma 2.0, HELM 2.0, and SMILES representations are precomputed per release with method, tool version, assumptions, input hash, status, and quality flags.
Contact Us
Dr. Zhixing Zhang
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology.
130 Meilong Road, Shanghai 200237, China.
2145573258@qq.comGitHub: https://github.com/IamzhangzixinProf. Yun Tang
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology.
130 Meilong Road, Shanghai 200237, China.
ytang234@ecust.edu.cnCitation and maintenance
PepDiana is maintained as a research data product. Please cite the database record and retain source identifiers when exporting evidence for reports, notebooks, model training, or downstream validation.
API and usage help