PepDiana
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Primary experimental recordPositive observation

PMC12429139::ACT025472

L-K5

Evidence text

Paper-level observation

Treatment with L-K5 ... at a concentration of 20 μM downregulated pERK expression by 91.2% (Section 2.4).
textConfidence: medium

Assay observation

Activity
Anticancer
Subtype
Anti-metastatic
Measure
percent_inhibition
Comparator
=
Raw observation
91.2%
Normalized measurement
=91.2%
Value minimum
Not reported by source
Value maximum
Not reported by source
Target
Homo sapiens
Assay method
Not reported by source
Sequence
IKKIVSKIKKLLNH
Standardization
ready simple

Source publication

Lysine-Leucine-Rich Frog Skin Antimicrobial Peptides Inhibit Breast Cancer Metastasis by Reprogramming Tumor-Associated Macrophage Polarization.

International Journal of Molecular Sciences · 2025

DOI 10.3390/ijms26178627 PMC12429139
Parent mention

Related peptide identities

PEPDIA-PLP-001298

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.