PepDiana

Analytics

Moonlight peptide landscape

Compare PepDiana's provenance-separated data layers, inspect primary experimental coverage, and trace multifunctional activity patterns without collapsing peptide identities into assay rows.

Browse records

Release landscape

Integrated identities and primary-literature evidence

PepDiana-V1-20260620

Integrated data

Peptide identities

82,224

26 resources across 25 stored namespaces

Cited publications

12,264

Distinct PMID or title-year publication identities

Activity records

376,740

Normalized source-database activity observations

Primary literature data

Peptide identities

3,375

Primary-only sequence and modification-aware identities

Source publications

3,682

2,768 papers retain activity observations

Experimental observations

55,908

Paper-level positive, negative, threshold, and qualitative records

Activity and moonlight landscape

Top-level activity classes

17

Distinct non-unknown Level 1 classes

Secondary annotations

735

Distinct non-unknown Level 2 labels

Moonlight peptides

14,868

Identities spanning at least two Level 1 classes

Primary literature evidence

Primary-literature evidence layer

First-hand paper evidence is stored separately from integrated database records, then linked back to canonical peptides when the sequence match is safe.

Search evidence

Activity records

55,908

One row per extracted first-hand experimental observation

Matched records

6,206

11.1% linked to current PepDiana peptides

Evidence-only

31,256

Records retained without unsafe canonical merging

Negative records

8,126

Inactive, threshold, or safety-negative observations

Evidence status

Evidence without sequence31,256Primary-literature peptide16,523Sequence-linked evidence6,206Complex or modified evidence1,923

Primary activity classes

Antimicrobial
20,590
Anticancer
7,564
Other
6,173
Toxicity
5,517
Immunomodulatory
5,503
Metabolic/Cardiovascular
5,280
Unknown
2,080
Antiviral
1,701

Sequence standardization

Sequence unresolved7,646
Sequence ready6,465
ready modified260
rejected16

Primary observation dimensions

Targets, measures, and experimental outcomes

Explore records

Most represented targets

Homo sapiensOrganism7,557
Mus musculusOrganism7,215
Escherichia coliOrganism4,325
Staphylococcus aureusOrganism4,211
Pseudomonas aeruginosaOrganism2,965
Klebsiella pneumoniaeOrganism1,539
Acinetobacter baumanniiOrganism1,381
Rattus norvegicusOrganism1,270

Assay measures

other15,385
MIC11,666
percent_inhibition6,800
qualitative4,246
cell_viability3,778
unknown2,156
MBC2,057
fold_change1,838

Result balance

Positive observations

47,782

85.5%

Negative / threshold

8,126

14.5%

Publication provenance

Source year and journal coverage

Counts represent distinct publications with retained activity records, not repeated assay rows.

Publications by year

1
06
2
07
4
08
2
10
8
11
5
12
9
13
14
14
16
15
11
16
21
17
22
18
32
19
41
20
60
21
97
22
132
23
218
24
1214
25
843
26

Leading journals

International Journal of Molecular Sciences169
Scientific Reports103
Nature Communications74
Molecules73
Foods68
Advanced Science61
Frontiers in Immunology59
Marine Drugs50

Moonlight evidence

Multifunctionality in formal primary-literature peptides

A peptide is counted as multifunctional here when its linked paper-level observations span at least two distinct primary activity classes.

888

multi-activity peptides · 26.3%

Distinct activity classes per peptide

1 class
2,487
2 classes
713
3 classes
136
4 classes
31
5 classes
8

Examples with broad activity evidence

LCKLSL

PEPDIA-PLP-001707

5 classes

Anticancer · Immunomodulatory · Metabolic/Cardiovascular · Other · Toxicity

16 observations

L-glutamine

PEPDIA-PLP-002269

5 classes

Antimicrobial · Antioxidant · Immunomodulatory · Other · Toxicity

16 observations

P4

PEPDIA-PLP-000777

5 classes

Anticancer · Antimicrobial · Immunomodulatory · Other · Toxicity

14 observations

MAVP

PEPDIA-PLP-001965

5 classes

Anticancer · Antioxidant · Immunomodulatory · Other · Toxicity

13 observations

DVGRG

PEPDIA-PLP-000492

5 classes

Anticancer · Antioxidant · Immunomodulatory · Other · Toxicity

12 observations

GRVPR

PEPDIA-PLP-001112

5 classes

Anticancer · Antioxidant · Immunomodulatory · Other · Toxicity

12 observations

Activity distribution

Evidence classes by record count

Antimicrobial
307,975
Antiviral
12,659
Anticancer
12,062
Metabolic/Cardiovascular
9,712
Toxicity
8,172
Clinical / Approved Drug
6,473
Neuroactive/Ion Channel
6,337
Cell-Penetrating
3,659
Bioregulatory
3,038
Unknown
2,410
Antiparasitic
2,169
Wound Healing
697
Enzyme Inhibitor
416
Antioxidant
328

Annotation confidence

Quality tiers

Silver60,547 · 73.6%Gold12,051 · 14.7%Bronze9,626 · 11.7%

Source contribution

Integrated database coverage

dramp36,168
dbaasp24,712
camp24,243
satpdb19,192
conoserver9,251
thpdb6,370
apd6,278
plantpepdb6,171
ahtpdb5,978
cancerppd3,430
hemolytik2,959
avpdb2,683
fermfoodb2,274
cppsite2,017
kalium1,616
arachnoserver1,455
b3pdb1,225
hipdb981
parapep863
tumorhope744
topicalpdb657
baamps563
acovpepdb518
aagingbase282
peptherdia120

Activity x annotation

Confidence profile by activity

Gold
Silver
Bronze
Antimicrobial137,30344.6%170,37055.3%3020.1%Antiviral7,63760.3%4,98939.4%330.3%Anticancer6,97657.8%5,01541.6%710.6%Metabolic/Cardiovascular8,09883.4%1,61416.6%-0%Toxicity5,42966.4%2,74333.6%-0%Clinical / Approved Drug731.1%3,84659.4%2,55439.5%Neuroactive/Ion Channel4667.4%5,86892.6%30%Cell-Penetrating1,30035.5%2,19159.9%1684.6%Bioregulatory762.5%2,95797.3%50.2%Unknown32013.3%2,07486.1%160.7%

Source x annotation

Source quality matrix

Gold
Silver
Bronze
DRAMP9,36325.9%26,48973.2%3160.9%DBAASP9,39338%15,31562%40%CAMP8,81736.4%15,42463.6%20%SATPDB10,00652.1%9,15047.7%360.2%CONOSERVER1561.7%3,90642.2%5,18956.1%THPDB671.1%3,76159%2,54239.9%APD3,70058.9%2,57741%10%PLANTPEPDB1,08117.5%4,89679.3%1943.1%AHTPDB5,49691.9%4828.1%-0%CANCERPPD3,17592.6%2547.4%10%

Source x activity

Source contribution by activity class

AntimicrobialAnticancerToxicityAntiviralMetabolic/CardiovascularUnknownBioregulatorydramp31,63673.5%5,32712.4%1,0862.5%3,6528.5%1000.2%3320.8%710.2%camp22,23681%1,6025.8%1,6336%1,4265.2%650.2%1920.7%830.3%satpdb10,30039.8%1,5436%4,02315.5%3,45813.4%1,7156.6%1,9107.4%7342.8%dbaasp18,98276.3%2,4319.8%1,6736.7%1,3275.3%1090.4%980.4%570.2%apd6,09873.2%6497.8%87410.5%3814.6%280.3%1381.7%1021.2%plantpepdb2,14833%3465.3%3154.8%1191.8%84713%3425.3%2,24634.5%conoserver220.6%140.4%1,23132.3%-0%-0%1,44838%20.1%thpdb40.1%10%-0%10%-0%-0%100.3%ahtpdb1226.1%371.9%20.1%140.7%1,69484.8%412.1%20.1%

Length distribution

Sequence scale bins

1-10
17,171
11-20
27,682
21-50
22,023
51-100
9,975
101+
5,373

Activity co-occurrence

Multi-label heatmap

AntimicrobialAnticancerAntiviralToxicityCell-PenetratingAntiparasiticNeuroactive/Ion ChannelUnknownAntimicrobial
-
5,377AND5,734AND2,151AND738AND726AND157AND285ANDAnticancer5,377AND
-
225AND398AND651AND176AND-AND-ANDAntiviral5,734AND225AND
-
165AND-AND-AND-AND-ANDToxicity2,151AND398AND165AND
-
-AND187AND221AND-ANDCell-Penetrating738AND651AND-AND-AND
-
-AND-AND-ANDAntiparasitic726AND176AND-AND187AND-AND
-
-AND-ANDNeuroactive/Ion Channel157AND-AND-AND221AND-AND-AND
-
380ANDUnknown285AND-AND-AND-AND-AND-AND380AND
-

Multi-source support

27,613+

Integrated records represented by multiple source databases. This measures provenance support, not multifunctionality.

Co-activity roadmap

20

The backend now exposes paired activity labels to support network views and multi-label benchmark design.

Benchmark-ready classes

14

Activity labels with enough evidence density to seed ML benchmark splits.

Versioned analysis assets

Reproducible downstream analysis

PepDiana exposes versioned tabular and sequence assets for statistical analysis, benchmark construction, and independent reproduction. Preserve the release identifier and manifest checksum with every downstream dataset.

FASTA

Versioned export

CSV

Versioned export

JSON

Versioned export