Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 765
Aptamer sequence: AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
Target unique ID: 4790
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_621 SS2-55 Molecule Phorate 1.11 μM 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 22261866
Structure information of aptamer
Aptamer Sequence: AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
The optimal secondary structure in dot-bracket notation: ..((..(((((.((((((....(((((...)))))....)))))))))))...))
The centroid secondary structure in dot-bracket notation: ..((..(((((.((((((....(((((...)))))....)))))))))))...))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_621 Description SS2-55
Aptamer chemistry DNA Length 55 nt
GC content 49.1% Molecular weight 16,989.91 Da
Molarity of 1 μg/μl solution 58.86 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
Applications Analysis and/or neutralization of the residues of the four organophosphorus pesticides
Target information
Type Detail Type Detail
PubChem ID 4790 Molecular name Phorate
Molecular formula C7H17O2PS3 Molecular weight 260.4
IUPAC name diethoxy-(ethylsulfanylmethylsulfanyl)-sulfanylidene-lambda5-phosphane InChIKey BULVZWIRKLYCBC-UHFFFAOYSA-N
LogP 3.728 Topological polar surface area 18.46
Hydrogen bond acceptor 5 Hydrogen bond donor 0

Synonym(s):
phorate; Thimet; 298-02-2; Granutox; Agrimet; Timet; Thimenox; Geomet; Vegfru; Thimet 10G; Vegfru foratox; American cyanamid 3,911; Thimet 10-G; Foraat; Phorat; VUAgT 182; O,O-Diethyl S-ethylmercaptomethyl dithiophosphate; Rcra waste number P094; Experimental insecticide 3911; Phosphorodithioic acid, O,O-diethyl S-((ethylthio)methyl) ester; ENT 24,042; AC 3911; O,O-Diethyl S-(ethylthio)methyl phosphorodithioate; Phosphorodithioic acid, O,O-diethyl S-[(ethylthio)methyl] ester; UNII-3W54X3W9IV; EI3911; L 11/6; O,O-Diethyl ethylthiomethyl phosphorodithioate; O,O-Diethyl S-ethylthiomethyl dithiophosphonate; O,O-Diethyl S-ethylthiomethyl thiothionophosphate; phosphatidylcholine O-34:2; O,O-Dietil-S-(etiltio-metil)-ditiofosfato; 3W54X3W9IV; CHEBI:38764; O,O-Diethyl-S-(ethylthio-methyl)-dithiofosfaat; O,O-Diaethyl-S-(aethylthio-methyl)-dithiophosphat; Dithiophosphate de O,O-diethyle et D'ethylthiomethyle; o,o-Diethyl S-[(ethylsulfanyl)methyl] dithiophosphate; O,O-diethyl S-[(ethylsulfanyl)methyl] phosphorodithioate; Phorat [German]; Foraat [Dutch]; Phorate-10G; Caswell No. 660; Thimet G; Phorate [ANSI:BSI:ISO]; Phorate 10G; CCRIS 2747; Thimet 10 G; HSDB 1183; EINECS 206-052-2; RCRA waste no. P094; EPA Pesticide Chemical Code 057201; BRN 1708517; Thimate; Volphor; Forate; AI3-24042; diethoxy-(ethylsulfanylmethylsulfanyl)-sulfanylidene-?^{5}-phosphane; Vegfru foratox.; O,O-Diethyl S-ethylmercaptomethyl dithiophosphonate; O,O-Diethyl-S-((ethylthio)methyl)phosphorodithioate; O,O-Dietil-S-(etiltio-metil)-ditiofosfato [Italian]; O,O-Diethyl-S-(ethylthio-methyl)-dithiofosfaat [Dutch]; Spectrum_001801; O,O-Diaethyl-S-(aethylthio-methyl)-dithiophosphat [German]; SpecPlus_000392; Dithiophosphate de O,O-diethyle et d'ethylthiomethyle [French]; Spectrum2_001860; Spectrum3_000816; Spectrum4_000656; Spectrum5_001942; O,O-Diethyl S-ethylthiomethyl dithiophosphate; Methanethiol, (ethylthio)-, S-ester with O,O-diethyl phosphorodithioate; Methanethiol, (ethylthio)-, S-ester with O,O-diethylphosphorodithioate; DSSTox_CID_12459; DSSTox_RID_78949; DSSTox_GSID_32459; SCHEMBL26312; BSPBio_002311; KBioGR_001031; KBioSS_002294; O,O-Diethyl S-(ethylthiomethyl) phosphorodithioate; DivK1c_006488; SPBio_001680; CHEMBL510014; DTXSID4032459; KBio1_001432; KBio2_002292; KBio2_004860; KBio2_007428; KBio3_001811; Phosphorodithioic acid, O,O-diethyl S-(ethylthio)methyl ester; ZINC2040889; Phorate 100 microg/mL in Methanol; Tox21_300398; CCG-39364; Phorate 10 microg/mL in Cyclohexane; Phorate 1000 microg/mL in Acetone; Phorate 1000 microg/mL in Toluene; Phorate 1000 microg/mL in Methanol; AKOS015898767; Phorate 100 microg/mL in Cyclohexane; NCGC00163889-01; NCGC00163889-02; NCGC00163889-03; NCGC00254280-01; CAS-298-02-2; DB-047653; Phorate, PESTANAL(R), analytical standard; 552-EP2274983A1; 552-EP2275422A1; 552-EP2305662A1; 552-EP2308857A1; C18690; o,o-diethyl s-ethylthiomethyl phosphorodithioate; O,O-diethyl-S-ethylthiomethylphosphorodithioate; 298P022; Q421197; J-017647; O,O-Diethyl S-(ethylthio)methyl phosphorodithioic acid; O,O-Diethyl S-[(ethylthio)methyl] phosphorodithioate; O,O-Diethyl S-[(ethylsulfanyl)methyl] dithiophosphate #; O,O-Diethyl S-[(ethylsulphanyl)methyl] dithiophosphate; O,O-Diethyl S-ethylmercaptomethyl dithiophosphoric acid; O,O-Diethyl S-[(ethylsulfanyl)methyl] dithiophosphoric acid; Phosphorodithioate, O,O-diethyl S-((ethylthio)methyl) ester; O,O-Diethyl S-[(ethylsulphanyl)methyl] dithiophosphoric acid; diethoxy-(ethylsulfanylmethylsulfanyl)-sulfanylidene-lambda5-phosphane; Methanethiol, (ethylthio)-, S-ester with O,O-diethyl phosphorodithioic acid

Activity data
Interaction ID 659
Target type Molecule
Target unique ID 90479
Activity 0.83 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Interaction ID 751
Target type Molecule
Target unique ID 14210
Activity 2.5 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Interaction ID 765
Target type Molecule
Target unique ID 4790
Activity 1.11 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Interaction ID 769
Target type Molecule
Target unique ID 38779
Activity 1 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_622 DNA AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG 67.27%
Apta_739 DNA ATCGTCTGCTCCGTCCAATAGCGTGCATTGGTTTACTGCATCCGTGAAACTGGGCTTTGGTGTGAGGTCGTGC 54.79%
Apta_4 DNA CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC 54.55%
Apta_267 DNA GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG 54.55%
Apta_340 DNA TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA 54.55%
Apta_255 DNA TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT 52.73%
Apta_348 DNA ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT 52.73%
Apta_506 DNA AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG 52.73%
Apta_510 DNA TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA 52.73%
Apta_596 DNA GGTGGCTGTTGGTCGAGGCTTATTAGTGTAGTCAATGGAGGCAGGCGACG 52.73%
Apta_642 DNA ATCCAATACCTCAGAACTCAGTTCGAGTCGTAAAGGGGAATCGCA 52.73%
Apta_912 DNA TAGTATGGACTTGTCTTCTTGTCAGAGTCTGGCAGCACGT 52.73%
Apta_977 DNA CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC 52.73%
Apta_1216 DNA AGCGTCCTCTGCATAGTGATTTACGCTATGTGTACAGTGC 52.73%
Apta_944 DNA ATACGACTCACTATTAGGGACAAAGCTGACAACCCTTTCATAATCTAACTACATTTATGTGCTAGACTACTGACTAC 51.95%
Apta_738 DNA ATCGTCTGCTCCGTCCAATACCTGCATATACACTTTGCATGTGGTTTGGTGTGAGGTCGTGC 51.61%
Apta_999 DNA ATAGGAGTCGACCGACCAGAGGACCCCGCTATCTAATTTATAGGCAATAAGTGCGTCTACATCTAGACTC 51.43%
Apta_3 DNA CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC 50.91%
Apta_7 DNA CCAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC 50.91%
Apta_222 DNA AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT 50.91%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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