AptaDB: Result

Interaction ID: 506

Aptamer sequence: UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG

Target unique ID: Q9H6S3

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_424	E03	Protein	ES8L2_HUMAN	3 nM	1X DPBS, 5 mM MgCl2, pH 7.1-7.5	21687663

Aptamer Sequence:	UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
The optimal secondary structure in dot-bracket notation:	.(((...((((.((((((.........))))......))))))...)))..
The centroid secondary structure in dot-bracket notation:	.(((...((((.((((((.........))))......))))))...)))..

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_424	Description	E03
Aptamer chemistry	RNA	Length	51 nt
GC content	45.1%	Molecular weight	16,378.78 Da
Molarity of 1 μg/μl solution	61.05 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	UGCUAGUAUAUCGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG
Applications	Be used to escort other anti-tumor or contrast agents

Type	Detail	Type	Detail
Uniprot ID	Q9H6S3	Protein name	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Gene name(s)	EPS8L2 EPS8R2 PP13181	Organism	Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Status	reviewed in uniprot database	Length	715
Mass	80,621	Activity regulation	N/A
Involvement in disease	Deafness, autosomal recessive, 106 (DFNB106)	Catalytic activity	N/A
PDB ID(s)	1WWU;1WXB;
Function	Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.

	Interaction ID	430
	Target type	Protein
	Target unique ID	Q01279
	Activity	29 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663
	Interaction ID	506
	Target type	Protein
	Target unique ID	Q9H6S3
	Activity	3 nM
	Binding Conditions/Buffer	1X DPBS, 5 mM MgCl2, pH 7.1-7.5
	Assay	Binding constants for Aptamers E03, E04, and E07
	PubMed ID	21687663

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_425	RNA	UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	90.20%
Apta_426	RNA	UGCCGCUAUAAUGCACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG	90.20%
Apta_92	RNA	ACAACUUAAUGCGACGUUGGUAAAGCAUAUCAAAC	52.94%
Apta_383	RNA	GGCGUGACCUGAUGAGUCACGCUAAGGAGGAUUUCCGAAAGCGGCUACGGUCCGCCAGUGUUACGAAACGUUCCC	52.00%
Apta_707	RNA	GGCCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUUCGACCACCUAGGCCGGU	51.67%
Apta_658	RNA	CUGCGAUCAGGGGUAAAUUUCCGCGCAGGCUCCACGCCGC	50.98%
Apta_709	RNA	AGUGAUACCAGCAUCGUCUUGAUGCCCUUGGCAGCACU	50.98%
Apta_758	RNA	GGCUUUCGGGCUUUCGGCAACAUCAGCCCCUCAGCC	50.98%
Apta_1140	RNA	UAGUGUGAGAGCCGUGAGUGAAAGGCCGCGACAAAGAUCGGA	50.98%
Apta_1248	RNA	GGGUGACUUUUCCCUCAGGCUCCUGUGAAGCAACCGAAUGGACUGAAAUGAAACCGCCC	50.85%
Apta_53	RNA	UCCCUGGCCCAAGAUCCUAAUAAAGUUUUUUCGGACCGGAGCGAAACCACUAUCCUCUUAAGCAAUCUGU	50.00%
Apta_130	RNA	GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA	49.28%
Apta_718	RNA	GGGUUGUGAGCUCCCGGCUCGCAUUGUGAGGUGGAGGGGGACGUGCUGCAGGUCGACGCAUGCGCCG	49.25%
Apta_447	RNA	ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC	49.12%
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	49.02%
Apta_85	RNA	UGCGACUGUUAUAACCUAACAGCGACGUAAAGAUA	49.02%
Apta_88	RNA	AAUAACCUUAAUGCGACGUUGGUUUGUCAACAACG	49.02%
Apta_96	RNA	UCGCUAAUUAUAGGCGGAGUGCGACGUUAUAAAUA	49.02%
Apta_241	RNA	GCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGG	49.02%
Apta_243	RNA	GCUUGAAGCUAGCAGUAAGACUAGCGCUACGGAUGGGUGUGCG	49.02%

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