Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 751
Aptamer sequence: AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
Target unique ID: 14210
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_621 | SS2-55 | Molecule | Omethoate | 2.5 μM | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 | 22261866 |
Structure information of aptamer
| Aptamer Sequence: | AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC |
| The optimal secondary structure in dot-bracket notation: | ..((..(((((.((((((....(((((...)))))....)))))))))))...)) |
| The centroid secondary structure in dot-bracket notation: | ..((..(((((.((((((....(((((...)))))....)))))))))))...)) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_621 | Description | SS2-55 |
| Aptamer chemistry | DNA | Length | 55 nt |
| GC content | 49.1% | Molecular weight | 16,989.91 Da |
| Molarity of 1 μg/μl solution | 58.86 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC | ||
| Applications | Analysis and/or neutralization of the residues of the four organophosphorus pesticides | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 14210 | Molecular name | Omethoate |
| Molecular formula | C5H12NO4PS | Molecular weight | 213.19 |
| IUPAC name | 2-dimethoxyphosphorylsulfanyl-N-methylacetamide | InChIKey | PZXOQEXFMJCDPG-UHFFFAOYSA-N |
| LogP | 0.866 | Topological polar surface area | 64.63 |
| Hydrogen bond acceptor | 5 | Hydrogen bond donor | 1 |
Synonym(s): OMETHOATE; Dimethoxon; 1113-02-6; Folimat; PO-Dimethoate; Dimethoate O-analog; Omethoat; Dimethoate-met; P=O-Rogor; Dimethoate PO isologue; O-Analog of dimethoate; Dimethoate oxygen analog; Bayer 45,432; BAY 45432; 2-Dimethoxyphosphinoylthio-N-methylacetamide; O,O-Dimethyl S-methylcarbamoylmethyl phosphorothioate; O,O-Dimethyl S-(N-methylcarbamoylmethyl) thiophosphate; O,O-Dimethyl S-((methylcarbamoyl)methyl)phosphorothioate; O,O-Dimethyl-S-(N-methylcarbamoylmethyl)phosphorothioate; 2-dimethoxyphosphorylsulfanyl-N-methylacetamide; ENT 25,776; O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorothiolate; UNII-28U28EWE79; CHEBI:38730; S6876; O,O-Dimethyl-S-(2-oxo-3-azabutyl)-monothiophosphate; Phosphorothioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester; Phosphorothioic acid, O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] ester; Dimethyl-S-(N-methyl-carbamoyl-methyl)phosphorothiolate; Phosphorothioic acid, O,O-dimethyl ester, S-ester with 2-mercapto-N-methylacetamide; O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl) phosphorothioate; O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl)phosphorothioate; 28U28EWE79; Acetamide, 2-mercapto-N-methyl-, S-ester with O,O-dimethyl phosphorothioate; O,O-Dimetil-S-(N-metil-carbamoil)-metil-monotiofosfato; O,O-Dimethyl S-[(methylcarbamoyl)methyl] phosphorothioate; O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] phosphorothioate; O,O-Dimethyl-S-((N-methyl-carbamoyl)-methyl)-monothiofosfaat; O-methoate; Thiophosphate de O,O-dimethyle et de S-(N-methylcarbamoyl) methyle; o,o-Dimethyl S-[2-(methylamino)-2-oxoethyl] thiophosphate; Omethoate [BSI:ISO]; Dimethoate Oxon; Bayer S-6876; HSDB 6715; EINECS 214-197-8; Bayer 45432; BRN 1785256; C5H12NO4PS; AI3-25776; Folimat 4E; S-6876; O,O-Dimethyl-S-(N-methyl-carbamoyl-methyl)-thiolphosphat [German]; O,O-Dimetil-S-(N-metil-carbamoil)-metil-monotiofosfato [Italian]; O,O-Dimethyl phosphorothioate S-ester with 2-mercapto-N-methylacetamide; O,O-Dimethyl-S-((N-methyl-carbamoyl)-methyl)-monothiofosfaat [Dutch]; O,O-Dimethyl-S-(N-methyl-carbamoyl)-methyl-monothiophosphat [German]; Thiophosphate de O,O-dimethyle et de S-(N-methylcarbamoyl) methyle [French]; DSSTox_CID_17580; DSSTox_RID_79343; DSSTox_GSID_37580; SCHEMBL63063; 4-04-00-00251 (Beilstein Handbook Reference); Omethoate, analytical standard; CHEMBL2270068; DTXSID4037580; Omethoate-d6(O,O-dimethyl-d6); O,O-Dimethyl-S-(N-methyl-carbamoyl-methyl)-thiolphosphat; O,O-Dimethyl-S-(N-methyl-carbamoyl)-methyl-monothiophosphat; ZINC2039915; Tox21_300968; BDBM50487987; MFCD00055441; Omethoate 100 microg/mL in Acetone; AKOS015893016; Omethoate 1000 microg/mL in Acetone; Omethoate 10 microg/mL in Acetonitrile; NCGC00160633-01; NCGC00160633-02; NCGC00254871-01; O358; CAS-1113-02-6; DB-040962; Omethoate, PESTANAL(R), analytical standard; C18662; F21411; 74440-EP2275422A1; 74440-EP2305662A1; 74440-EP2308857A1; 113O026; J-002555; Q2204769; O,O-dimethyl S-2-(methylamino)-2-oxoethyl phosphorothioate; O,O-Dimethyl-S-(N-methyl-carbamoyl-methyl)-thiolphosphate; O,O-Dimethyl S-[2-(methylamino)-2-oxoethyl] thiophosphate #; O,O-Dimethyl-S-(N-methyl-carbamoyl)-methyl-monothiophosphate
Activity data
 |
Interaction ID | 659 |
| Target type | Molecule | |
| Target unique ID | 90479 | |
| Activity | 0.83 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 751 |
| Target type | Molecule | |
| Target unique ID | 14210 | |
| Activity | 2.5 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 765 |
| Target type | Molecule | |
| Target unique ID | 4790 | |
| Activity | 1.11 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 769 |
| Target type | Molecule | |
| Target unique ID | 38779 | |
| Activity | 1 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_622 | DNA | AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG | |
| Apta_739 | DNA | ATCGTCTGCTCCGTCCAATAGCGTGCATTGGTTTACTGCATCCGTGAAACTGGGCTTTGGTGTGAGGTCGTGC | |
| Apta_4 | DNA | CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC | |
| Apta_267 | DNA | GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG | |
| Apta_340 | DNA | TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA | |
| Apta_255 | DNA | TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT | |
| Apta_348 | DNA | ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT | |
| Apta_506 | DNA | AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG | |
| Apta_510 | DNA | TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA | |
| Apta_596 | DNA | GGTGGCTGTTGGTCGAGGCTTATTAGTGTAGTCAATGGAGGCAGGCGACG | |
| Apta_642 | DNA | ATCCAATACCTCAGAACTCAGTTCGAGTCGTAAAGGGGAATCGCA | |
| Apta_912 | DNA | TAGTATGGACTTGTCTTCTTGTCAGAGTCTGGCAGCACGT | |
| Apta_977 | DNA | CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC | |
| Apta_1216 | DNA | AGCGTCCTCTGCATAGTGATTTACGCTATGTGTACAGTGC | |
| Apta_944 | DNA | ATACGACTCACTATTAGGGACAAAGCTGACAACCCTTTCATAATCTAACTACATTTATGTGCTAGACTACTGACTAC | |
| Apta_738 | DNA | ATCGTCTGCTCCGTCCAATACCTGCATATACACTTTGCATGTGGTTTGGTGTGAGGTCGTGC | |
| Apta_999 | DNA | ATAGGAGTCGACCGACCAGAGGACCCCGCTATCTAATTTATAGGCAATAAGTGCGTCTACATCTAGACTC | |
| Apta_3 | DNA | CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC | |
| Apta_7 | DNA | CCAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC | |
| Apta_222 | DNA | AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT |
DEV TOOL
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