Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 659
Aptamer sequence: AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
Target unique ID: 90479
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_621 SS2-55 Molecule Isocarbophos 0.83 μM 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 22261866
Structure information of aptamer
Aptamer Sequence: AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
The optimal secondary structure in dot-bracket notation: ..((..(((((.((((((....(((((...)))))....)))))))))))...))
The centroid secondary structure in dot-bracket notation: ..((..(((((.((((((....(((((...)))))....)))))))))))...))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_621 Description SS2-55
Aptamer chemistry DNA Length 55 nt
GC content 49.1% Molecular weight 16,989.91 Da
Molarity of 1 μg/μl solution 58.86 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
Applications Analysis and/or neutralization of the residues of the four organophosphorus pesticides
Target information
Type Detail Type Detail
PubChem ID 90479 Molecular name Isocarbophos
Molecular formula C11H16NO4PS Molecular weight 289.29
IUPAC name propan-2-yl 2-[amino(methoxy)phosphinothioyl]oxybenzoate InChIKey YFVOXLJXJBQDEF-UHFFFAOYSA-N
LogP 2.46 Topological polar surface area 70.78
Hydrogen bond acceptor 5 Hydrogen bond donor 1

Synonym(s):
Isocarbophos; 24353-61-5; Optunal; Isocarbofos; propan-2-yl 2-[amino(methoxy)phosphinothioyl]oxybenzoate; Isopropyl 2-((aminomethoxyphosphinothioyl)oxy)benzoate; O-Methylphosphoramidothioate, O-ester with isopropyl salicylate; CHEBI:38704; Benzoic acid, 2-((aminomethoxyphosphinothioyl)oxy)-, 1-methylethyl ester; Benzoic acid, 2-[(aminomethoxyphosphinothioyl)oxy]-, 1-methylethyl ester; isopropyl O-(methoxyaminothiophosphoryl)salicylate; propan-2-yl 2-{[amino(methoxy)phosphorothioyl]oxy}benzoate; Caswell No. 574B; Bay 93820; EINECS 246-192-1; EPA Pesticide Chemical Code 574300; BRN 2946521; C11H16NO4PS; AI3-27659; O-Methyl phosphoramidothioate, O-ester with isopropyl salicylate; O-Methylphosphoramidothioate; DSSTox_CID_22063; DSSTox_RID_79913; DSSTox_GSID_42063; SCHEMBL117792; CHEMBL3185588; DTXSID7042063; O-ester with isopropyl salicylate; Isopropyl salicylate O-ester with O-methylphosphoramidothioate; ZAA35361; Tox21_301328; BAY-93820; Salicylic acid, isopropyl ester, ester with O-methyl phosphoramidothioate; Isocarbofos 1000 microg/mL in Acetone; Isocarbofos 10 microg/mL in Cyclohexane; NCGC00255827-01; Isocarbofos 100 microg/mL in Cyclohexane; O517; CAS-24353-61-5; Isocarbophos, PESTANAL(R), analytical standard; 353I615; Q-201253; isopropyl 2-(amino(methoxy)phosphorothioyloxy)benzoate; Q27117953; UNII-7741NPW06X component YFVOXLJXJBQDEF-KRWDZBQOSA-N; Pesticide1_Isocarbophos_C11H16NO4PS_Benzoic acid, 2-[(aminomethoxyphosphinothioyl)oxy]-, 1-methylethyl ester

Activity data
Interaction ID 659
Target type Molecule
Target unique ID 90479
Activity 0.83 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Interaction ID 751
Target type Molecule
Target unique ID 14210
Activity 2.5 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Interaction ID 765
Target type Molecule
Target unique ID 4790
Activity 1.11 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Interaction ID 769
Target type Molecule
Target unique ID 38779
Activity 1 μM
Binding Conditions/Buffer

300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3
Assay

Specifificity of SS2-55 and SS4-54 aptamers
PubMed ID 22261866
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_622 DNA AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG 67.27%
Apta_739 DNA ATCGTCTGCTCCGTCCAATAGCGTGCATTGGTTTACTGCATCCGTGAAACTGGGCTTTGGTGTGAGGTCGTGC 54.79%
Apta_4 DNA CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC 54.55%
Apta_267 DNA GAGTGCGTAATGGTACGATTTGGGAAGTGGCTTGGGGTGG 54.55%
Apta_340 DNA TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA 54.55%
Apta_255 DNA TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT 52.73%
Apta_348 DNA ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT 52.73%
Apta_506 DNA AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG 52.73%
Apta_510 DNA TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA 52.73%
Apta_596 DNA GGTGGCTGTTGGTCGAGGCTTATTAGTGTAGTCAATGGAGGCAGGCGACG 52.73%
Apta_642 DNA ATCCAATACCTCAGAACTCAGTTCGAGTCGTAAAGGGGAATCGCA 52.73%
Apta_912 DNA TAGTATGGACTTGTCTTCTTGTCAGAGTCTGGCAGCACGT 52.73%
Apta_977 DNA CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC 52.73%
Apta_1216 DNA AGCGTCCTCTGCATAGTGATTTACGCTATGTGTACAGTGC 52.73%
Apta_944 DNA ATACGACTCACTATTAGGGACAAAGCTGACAACCCTTTCATAATCTAACTACATTTATGTGCTAGACTACTGACTAC 51.95%
Apta_738 DNA ATCGTCTGCTCCGTCCAATACCTGCATATACACTTTGCATGTGGTTTGGTGTGAGGTCGTGC 51.61%
Apta_999 DNA ATAGGAGTCGACCGACCAGAGGACCCCGCTATCTAATTTATAGGCAATAAGTGCGTCTACATCTAGACTC 51.43%
Apta_3 DNA CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC 50.91%
Apta_7 DNA CCAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC 50.91%
Apta_222 DNA AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT 50.91%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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